Aripiprazole in Juvenile Bipolar Disorder Comorbid with Attention-Deficit/Hyperactivity Disorder:An Open Clinical Trial

Abstract

Aripiprazole was effective in improving mania and ADHD symptoms, but neither JBD nor ADHD symptom remission was observed in most of the cases. Randomized placebo-controlled trials for JBD and ADHD are needed.

Aripiprazole in Children and Adolescents with Conduct Disorder: A Single-Center, Open-Label Study

“…Our fi ndings are consistent with those of Lyon et al [ 35 ] , who reported that the eff ect size of aripiprazole was d = 0.59 for hyperactivity and d = 0.47 for attention defi cits. In another study conducted with youths with juvenile bipolar disorder comorbid with ADHD, however, the eff ect size of aripiprazole at improving ADHD symptoms was d = 1.05, which is much higher than our fi ndings [ 16 ] . In this study, aripiprazole was well tolerated, and none of the participants dropped out of the study due to side eff ects.…”

“…We classifi ed all 20 patients as having severe CD. Of these patients, 16 were aggressive toward others, 3 had previously stolen, and 1 had run away from home. The mean IQ of the children was 84.10 (± 11.42).…”

“…Aripiprazole reduced ADHD symptoms and improved overall functioning with no cognitive deterioration [ 14 ] . Aripiprazole also improved mania and ADHD symptoms in an open-label study conducted with 10 children and adolescents diagnosed with juvenile bipolar disorder comorbid with ADHD [ 16 ] . To the best of our knowledge, only one aripiprazole study has been conducted using children with CD [ 17 ] .…”

Pharmacotherapy of bipolar disorder in children and adolescents: an update

“…Data are summarized in Table 2. [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] Case reports and case series were detected, but were not included in the text due to the availability of higher-level evidence for the psychopharmacological agents of interest. Nevertheless, we recommend analysis of these case series and reports, which are available from the authors on request.…”

Diminished 5‐HT functioning in CBCL pediatric bipolar disorder‐profiled ADHD patients versus normal ADHD: susceptibility to rapid tryptophan depletion influences reaction time performance

“…The TPH-2 in particular was discussed to influence BD itself and suicide attempts in patients with BD (Lopez et al, 2007). As regards the underlying neurobiological mechanisms of BD, the possible co-morbidity of PBD and ADHD has been investigated in a variety of studies (Biederman et al, 1996(Biederman et al, , 2007Singh et al, 2006;Goldberg and McElroy, 2007;Masi et al, 2007;Scheffer, 2007;Tramontina et al, 2007;Wingo and Ghaemi, 2007;Holtmann et al, 2007Holtmann et al, , 2008. A recent study investigating the phosphatidylinositol and glutamatergic metabolism in the anterior cingulate cortex of children and adolescents with ADHD, ADHD plus BD and controls via proton magnetic resonance spectroscopy showed that differences in glutamatergic neurotransmission may also reflect changes in 5-HT and also possibly in dopaminergic pathways (Moore et al, 2006).…”