Are peri‐implantitis lesions different from periodontitis lesions?

Berglundh, Tord; Zitzmann, Nicola U.; Donati, Mauro

doi:10.1111/j.1600-051x.2010.01672.x

Cited by 291 publications

(314 citation statements)

References 74 publications

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“…Microbial overgrowth around compromised tooth sockets triggers exorbitant host inflammation. Both types of conditions have identical origins, but the pathogenic pathways are different between the natural teeth versus the artificial implant due to various factors (Berechet, Ionaşcu, Sîrbu, & Sîrbu, 2013; Berglundh, Zitzmann, & Donati, 2011). …”

Section: Introductionmentioning

confidence: 99%

“…In vivo studies on inflammatory cell infiltration also reveal that during inflammation of the peri‐implant tissues and periodontal tissue, the inflammatory cells infiltrate more apically towards the peri‐implant mucosa than in the periodontal tissue or gingiva around the natural tooth. This is due to peri‐implant tissue has a less protective capacity than periodontal tissue in terms of lower tissues buffering, healing, and regeneration (Berechet et al, 2013; Berglundh et al, 2011; Dhir et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

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Comparison of biofilm formation and migration of Streptococcus mutans on tooth roots and titanium miniscrews

Laosuwan

Epasinghe

et al. 2018

Clinical & Exp Dental Res

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Periodontitis and peri‐implantitis are inflammatory diseases caused by periodontal pathogenic bacteria leading to destruction of supporting periodontal/peri‐implant tissue. However, the progression of inflammatory process of these two diseases is different. The bacterial biofilm is the source of bacteria during the inflammatory process. As the bacteria migrate down the surface of tooth or titanium implant, the inflammation spreads along with it. Streptococcus mutans has an important role in oral bacterial biofilm formation in early stage biofilm before the microbiota shift to late stage and become more virulent. The other major difference is the existence of periodontal ligament (PDL) cells in normal teeth but not in peri‐implant tissue. This study aims to compare the S. mutans bacterial biofilm formation and migration on 2 different surfaces, tooth root and titanium miniscrew. The biofilm was grown with a flow cells system to imitate the oral dynamic system with PDL cells. The migration distances were measured, and the biofilm morphology was observed. Data showed that the biofilm formation on miniscrew was slower than those on tooth root at 24 hr. However, there were no difference in the morphology of the biofilm formed on the tooth root with those formed on the miniscrew at both 24 and 48 hr. The biofilm migration rate was significantly faster on miniscrew surface compare with those on tooth root when observe at 48 hr (p < .001). There are no significant differences in biofilm migration within miniscrew group and tooth root group despite the exiting of PDL cell (p > .05). The biofilm's migration rate differences on various surfaces could be one of the factors accounting for the different inflammatory progression between periodontitis and peri‐implantitis disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of biofilm formation and migration of Streptococcus mutans on tooth roots and titanium miniscrews

Laosuwan

Epasinghe

et al. 2018

Clinical & Exp Dental Res

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“…Se les consideran dos entidades similares pero con ciertas diferencias fundamentales. 19 La reacción inflamatoria inicial a la biopelícula bacteriana a las 3 semanas es similar en la unión dentogingival que en la unión implantomucosa. Sin embargo, luego de tres meses de acumulación persistente de placa bacteriana el infiltrado inflamatorio es mucho mayor en la mucosa peri implantaria que en la encía.…”

Section: Periimplantitisunclassified

Factores de riesgo y periimplantitis en la terapia implantológica. Revisión narrativa.

Bravo¹,

Castro²,

Grados³

2013

Joralres

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REVIEWFactores de riesgo y periimplantitis en la terapia implantológica. Revisión narrativa.Bravo F, Castro Y & Grados S. Factores de riesgo y periimplantitis en la terapia implantológica. Revisión narrativa. J Oral Res 2013; 2(3): 139-144.Resumen: Las enfermedades que involucran a los tejidos que rodean a los dientes y a los implantes osteointegrados son el resultado de una interacción entre algún tipo de agente patológico (bacteriano, viral, etc.) y la respuesta inmunitaria del huésped. Estas interacciones se pueden dar tanto en los tejidos dentarios como en aquellos biomateriales que se introducen para tratar de corregir algún tipo de patología periodontal; los implantes al ser sustitutos biocompatibles de las piezas dentarias no están exentas de este tipo de interacciones que muchas veces cursan con patologías periodontales y periimplantarias. La periimplantitis es un tipo de patología que resulta de dicha interacción; los factores de riesgo e indicadores de riesgo de la periimplantitis son amplios y complejos. El presente artículo resume las múltiples fuentes de información de la literatura científica para abordar al detalle los aspectos de los principales factores de riesgo y la periimplantitis en la terapia implantológica.. Palabras clave: Implantes dentales, mucosa periimplantaria, periodontitis crónica, factores de riesgo.Risk factors and periimplantitis in implant therapy. Narrative review.Abstract: Diseases involving tissue around the teeth and osseointegrated implants are the result of an interaction between some type of pathological agent (bacterial, viral, etc.) and host immune response. These interactions can occur both in the dental tissues as those biomaterials which are introduced to attempt to correct some type of periodontal disease, the implant being a biocompatible substitute of the teeth is not free from this type of interaction often enrolled periodontal and peri-implant pathology. The peri-implantitis is a type of disease that results from this interaction, the risk factors and risk indicators of peri-implantitis are broad and complex. This article summarizes the multiple sources of information in the scientific literature to address in detail the aspects of the main risk factors and the peri-implantitis in the peri implant therapy.

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“…As in osteolysis around an orthopedic implant,29 peri‐implantitis shows a similar infiltration of macrophages, and the macrophage infiltration is more pronounced in peri‐implantitis than in an infectious disease such as periodontitis 30…”

Section: Introductionmentioning

confidence: 99%

Effect of cobalt ions on the interaction between macrophages and titanium

Pettersson

Thorén

et al. 2018

J Biomedical Materials Res

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Inflammation and bone reduction around dental implants are described as peri‐implantitis and can be caused by an inflammatory response against bacterial products and toxins. Titanium (Ti) forms aggregates with serum proteins, which activate and cause release of the cytokine interleukin (IL‐1β) from human macrophages. It was hypothesized that cobalt (Co) ions can interact in the formation of pro‐inflammatory aggregates, formed by titanium. To test this hypothesis, we differentiated THP‐1 cells into macrophages and exposed them to Ti ions alone or in combination with Co ions to investigate if IL‐1β release and cytotoxicity were affected. We also investigated aggregate formation, cell uptake and human biopsies with inductively coupled plasma atomic emission spectroscopy and electron microscopy. Co at a concentration of 100 µM neutralized the IL‐1β release from human macrophages and affected the aggregate formation. The aggregates formed by Ti could be detected in the cytosol of macrophages. In the presence of Co, the Ti‐induced aggregates were located in the cytosol of the cultured macrophages, but outside the lysosomal structures. It is concluded that Co can neutralize the Ti‐induced activation and release of active IL‐1β from human macrophages in vitro. Also, serum proteins are needed for the formation of metal‐protein aggregates in cell medium. Furthermore, the structures of the aggregates as well as the localisation after cellular uptake differ if Co is present in a Ti solution. Phagocytized aggregates with a similar appearance seen in vitro with Ti present, were also visible in a sample from human peri‐implant tissue. © 2018 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A:2518–2530, 2018.

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Are peri‐implantitis lesions different from periodontitis lesions?

Cited by 291 publications

References 74 publications

Comparison of biofilm formation and migration of Streptococcus mutans on tooth roots and titanium miniscrews

Comparison of biofilm formation and migration of Streptococcus mutans on tooth roots and titanium miniscrews

Factores de riesgo y periimplantitis en la terapia implantológica. Revisión narrativa.

Effect of cobalt ions on the interaction between macrophages and titanium

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