Are age, anthropometry and components of metabolic syndrome-risk factors interrelated with lower urinary tract symptoms in patients with erectile dysfunction? A prospective study

Paick, Jae‐Seung; Yang, Jihyun; Kim, Soowoong; Ku, Ja-Hyeon

doi:10.1111/j.1745-7262.2007.00211.x

Cited by 13 publications

(13 citation statements)

References 34 publications

(56 reference statements)

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“…Paick et al. showed that metabolic profiles are related to IPSS data [18]. Finally, Giovannucci et al.…”

Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that the analyses of continuously coded BMI on CPSI scale score failed to reveal any statistically significant relationship ( P = 0.2). Therefore, the presence of a true effect between BMI and CPSI scale score should be interpreted with caution, since analyses of categorically coded data can exaggerate an existing relationship by introducing artificial cutoffs [18].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, a link was reported between the metabolic syndrome and lower urinary tract symptoms (LUTS) [15–17]. Moreover, several investigators reported on the association of urological symptoms, ED, and the metabolic syndrome [18–21]. The link between elevated BMI and other male disorders might be equally strong.…”

Section: Introductionmentioning

confidence: 90%

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Body Mass Index and its Association with Genitourinary Disorders in Men Undergoing Prostate Cancer Screening

Bhojani

Perrotte

Hutterer

et al. 2008

The Journal of Sexual Medicine

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Introduction Elevated body mass index (BMI) may predispose to several pelvic pathologies. Aims We tested the association between BMI and five end points, namely, (i) erectile dysfunction (ED); (ii) lower urinary tract symptoms (LUTS); (iii) chronic prostatitis-associated pain (CPP); and ejaculatory dysfunction that is subdivided between (iv) pain/discomfort on ejaculation; and (v) subjectively decreased ejaculate volume. Methods Age, height, and weight were prospectively recorded in a cohort of 590 consecutive healthy men undergoing prostate cancer screening. Continuously coded and categorized BMI (World Health Organization classification) were studied. Main Outcome Measures Age-adjusted analyses relied on logistic and linear regression models, according to data type. Results The average age was 54.1 years (range 30–83). Of all, 296 were overweight (50.2%, BMI 25–29.9 kg/m2) and 85 were obese (14.4%, BMI ≥ 30 kg/m2). After age adjustment, elevated continuously coded BMI (P < 0.001) and elevated categorized BMI (P = 0.01) were associated with worse erectile function. Conversely, after age adjustment, elevated continuously coded BMI (P = 0.02) and elevated categorized BMI (P = 0.05) were associated with a lower rate of subjectively decreased ejaculate volume. Finally, after age adjustment, elevated categorically coded BMI was related to lower rates of CPP (P < 0.001) and to a lower rate of pain/discomfort on ejaculation (P = 0.03). Conclusions In men undergoing prostate cancer screening, the effect of BMI on the five end points is not invariably detrimental. Elevated BMI may predispose to ED, but may also decrease the rate of pain/discomfort on ejaculation and may lower the reported rate of subjectively decreased ejaculate volume. Finally, it appeared to have no effect on LUTS.

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“…Paick et al. showed that metabolic profiles are related to IPSS data [18]. Finally, Giovannucci et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Body Mass Index and its Association with Genitourinary Disorders in Men Undergoing Prostate Cancer Screening

Bhojani

Perrotte

Hutterer

et al. 2008

The Journal of Sexual Medicine

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“…Several community-based studies have reported a statistically significant association between LUTS and erectile dysfunction (ED) [11][12][13]. Furthermore, recent studies have suggested that benign prostate hyperplasia (BPH) and LUTS are components of metabolic syndrome and that BPH and LUTS patients may share the same metabolic abnormalities as patients with metabolic syndrome [14][15][16]. These interrelationships suggest that features of metabolic syndrome, particularly in association with testosterone deficiency result in microanatomical changes leading to tissue fibrosis and loss of elasticity, explaining the lower urinary tract symptoms often encountered in testosteronedeficient men.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of testosterone administration on symptoms of the lower urinary tract in men with late-onset hypogonadism: A pilot study

Калинченко

et al. 2008

The Aging Male

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“…There are several similarities in the etiologies of ED and LUTS, such as metabolic syndrome, autonomic nervous activity, nitric oxide (NO) activity, arteriosclerosis, pelvic ischemia, and Rho-kinase activity [13]. Furthermore, recent studies suggested that BPH and LUTS are significantly associated with metabolic syndrome, and that patients with LUTS may share the same metabolic abnormalities as those with metabolic syndrome [14-16]. These findings suggest a relation between declines of testosterone and LUTS.…”

Section: Serum Sex Hormones and Lower Urinary Tract Symptomsmentioning

confidence: 99%

Late-Onset Hypogonadism Syndrome and Lower Urinary Tract Symptoms

Shigehara

Namiki

2011

Korean J Urol

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Androgen replacement therapy (ART) is a widely accepted form of treatment worldwide for aging men with late-onset hypogonadism (LOH) syndrome. Concurrent with the progressive decline in testosterone from middle age, there is a gradual increase in prostate volume, reflecting the development of benign prostatic hyperplasia (BPH). Prostate growth is dependent on the presence of androgens, and conversely, antiandrogen agents or orchidectomy can decrease prostate volume in patients with BPH. Thus, it is important to investigate whether ART could have any negative effects on prostatic disease or lower urinary tract symptoms (LUTS). Although only limited amounts of information on the correlations between androgen levels in aging men and clinical manifestations of LUTS are available, a few recent studies have suggested that testosterone levels may have some beneficial effects on various urinary functions in men. Androgen receptors are found in the urothelium, urinary bladder, prostate, and urethra, and testosterone could have an impact on the autonomic nervous system, bladder smooth muscle differentiation, nitric oxide synthase, phosphodiesterase-5 and Rho/Rho-kinase activities, and pelvic blood flow. In addition, some previous studies demonstrated that ART had little effect on LUTS or urinary function in aging men with LOH syndrome. Furthermore, some recent randomized controlled trials indicated that short-term ART may be effective in the improvement of LUTS in hypogonadal men with mild BPH. However, only limited information is available regarding the effects of longer-term ART or the safety of ART in men with severe BPH and LUTS, and further studies are required to reach more definitive conclusions.

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Are age, anthropometry and components of metabolic syndrome-risk factors interrelated with lower urinary tract symptoms in patients with erectile dysfunction? A prospective study

Abstract: The results of the present study indicate that some metabolic profiles might influence LUTS in men with ED.

Cited by 13 publications

References 34 publications

Body Mass Index and its Association with Genitourinary Disorders in Men Undergoing Prostate Cancer Screening

Body Mass Index and its Association with Genitourinary Disorders in Men Undergoing Prostate Cancer Screening

Beneficial effects of testosterone administration on symptoms of the lower urinary tract in men with late-onset hypogonadism: A pilot study

Late-Onset Hypogonadism Syndrome and Lower Urinary Tract Symptoms

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