Arc Plasma-Based Dissociation Device: Fingerprinting Mass Spectrometric Analysis Realized at Atmospheric Condition

Zhu, Suzhen; Zhang, Li; Zhang, Jing; Guo, Yinlong

doi:10.1021/acs.analchem.0c03127

Cited by 14 publications

(15 citation statements)

References 55 publications

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“…The discharge temperature is relatively high (about 600 °C), thus it was used as an electronic lighter to ignite gas or cigarette commercially. Arc discharge has been reported as an ambient ionization for MS. 25 Inspired by this, we intended to refit the electronic lighter as an ambient arc discharge ion source for its tiny size and "pointand-shoot" manner. However, the arc discharge with a high temperature will ignite most organic substances (which is dangerous!…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Chen

Meng

et al. 2021

Anal. Chem.

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Current ambient ionization sources for mass spectrometry (MS) are typically connected to gas cylinders, high-voltage supply, injection pump, and other accessory equipment, which hinder the popularization of MS in the field of on-site detection. Here, we developed a wireless pocket-size "MasSpec Pointer" (weights 65 g) based on arc discharge powered by a 3.7 V polymer Li battery for ambient ionization MS. A high voltage of 5600 V and 20 kHz was generated from the boost coil to penetrate air and form a plasma. The relative standard deviation (RSD) of the high-voltage pulses is 3.8%, leading to a stable discharge and a good quantification performance. A mini diaphragm pump was used to cool the plasma from ∼600 to ∼40 °C and to blow the plasma into a jet, which facilitates sampling. MasSpec Pointer can work well at both positive-and negative-ion modes without any modification and can quickly test gaseous, liquid, or solid samples. The limit of detection of this device for atrazine (an agrochemical) is lower than 0.1 ng/mL. MasSpec Pointer has shown its ability to pinpoint the double-bond location of fatty acid isomers without derivatization reagents or light illumination. Agrochemicals from the surface of an apple and daily chemicals from the surface of a finger were detected successfully using MasSpec Pointer coupled with a miniature mass spectrometer. We believe the "point-and-shoot" device coupled with mini-MS brings the hope for an age of detecting chemicals on-site by nonprofessionals.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Chen

Meng

et al. 2021

Anal. Chem.

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“…In addition, both even (m/z 227, 142, 128, 114, 100, and 84) and odd (m/z 226, 209, 198, 184, and 170) electron ions were generated, which shows the characteristic of the APD-induced dissociation process as were discussed further in our previous work. 29,31,32 Thus, this technique generates interpretable informative mass spectra with strong regularity for rapid fingerprinting of the target polymer.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The APD device was built according to our previous work . Simply put, a high DC voltage of up to 20 kV was used to generate and maintain stable arc discharge between two mental electrodes under atmospheric conditions.…”

Section: Experimental Sectionmentioning

confidence: 88%

“…The APD device was built according to our previous work. 29 Simply put, a high DC voltage of up to 20 kV was used to generate and maintain stable arc discharge between two mental electrodes under atmospheric conditions. Analytes can be introduced by simply fixing with clips above the middle of the arc column (within 0.5 cm).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…Previously, we reported a novel arc plasma-based dissociation (APD) device, which can induce the dissociation of organic compounds in diverse patterns owing to its high energy, high temperature, and unique chemical reactivity. 29 The device is easy to build by simply applying high voltage supply to electrodes and using atmospheric air as discharge gas. Samples were loaded by adhering to a glass rod (Dip-it sampler) or simple fixing.…”

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confidence: 99%

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Rapid Characterization of Polymer Materials Using Arc Plasma-Based Dissociation-Mass Spectrometry

et al. 2021

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Fingerprinting spectra of polymer materials containing information of monomers' molecular weight and detailed structure, constituents, and sequences were obtained by a direct analytical process using arc plasma-based dissociation (APD)−mass spectrometry. The thermal arc plasma generated using a simple arc discharge device induces the dissociation of the polymeric backbone, producing mass spectra with strong regularity within seconds. The molecular weight of the repeating unit was revealed by equal intervals between peak series and protonated monomer ions in the mass spectra. Meanwhile, lots of secondary fragment ions were produced to provide abundant structural information. For polyethers, it is even possible to decipher (read) the "sequence" directly from their spectra. Polymers composed of isomers or only differing in their initiator moieties were easily distinguished with their characteristic APD mass spectra. The spectra were highly reproducible according to the results of similarity calculation. Unlike pyrolysis mass spectrometry, in the APD device, polymers in liquid, solid, powder, and crude samples can be analyzed directly without any pretreatment, and the regular spectra are easier to interpret. Compared with other direct analytical methods, more structural informative spectra can be acquired owing to the high energy, high temperature, and unique chemical reactivity of arc plasma. Thus, this technique is promising to be a valuable tool in rapid elucidation of polymer materials.

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Applications of ambient electric arc ionization mass spectrometry in saline samples

Gao

Zhan

et al. 2022

Chinese Chemical Letters

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Arc Plasma-Based Dissociation Device: Fingerprinting Mass Spectrometric Analysis Realized at Atmospheric Condition

Cited by 14 publications

References 55 publications

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Rapid Characterization of Polymer Materials Using Arc Plasma-Based Dissociation-Mass Spectrometry

Applications of ambient electric arc ionization mass spectrometry in saline samples

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