Applications of ambient electric arc ionization mass spectrometry in saline samples

Li, Yuan; Gao, Yuanji; Zhan, Binpeng; Chen, Weiwei; Chu, Fengjian; Feng, Hongru; Gao, Zhan; Ma, Zihan; Pan, Yuanjiang

doi:10.1016/j.cclet.2021.08.119

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…It generates high voltage and high-frequency arcs and a series of reactive species that react with the analyte and produce ions. However, the stability of arc-plasma ionization can be influenced by air humidity, air flow and the atmospheric pollutants around the ion source . Additionally, the substantial amount of heat generated by the arc discharge makes it challenging to analyze thermally labile compounds, and the accumulation of heat also restricts long-time operation.…”

Section: Resultsmentioning

confidence: 99%

Plasma-Excited Nebulizer Gas-Assisted Electrospray Ionization: Enhancing the Sensitivity of Pesticide in Mass Spectrometry

Bao,

Bai,

Wang

et al. 2023

Anal. Chem.

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Liquid chromatography–mass spectrometry (LC-MS) is widely used in the detection of pesticide residues. However, the detection sensitivity of low-polarity pesticides by commonly used electrospray ionization may be severely suppressed, which greatly affects the limit of detection and repeatability. Herein, a plasma-excited nebulizer gas-assisted electrospray ionization (PENG-ESI) device has been developed. By introducing the discharge plasma formed by Tesla coil into the electrospray nebulizer gas channel, the sensitivity of low-polarity pesticides was significantly increased while maintaining sensitivity to polar pesticides. Under the optimized conditions, the limit of detection for S-bioallethrin was achieved at the level of 100 pg/g with good linearity (R 2 > 0.99) and precision (RSD ≤ 4.61%). The matrix effect of a series of spiked matrix samples is less than 13.1%. Finally, different pyrethroid pesticide residues were successfully analyzed without separation, highlighting that the technology has potential application prospects in food quality control, environmental monitoring, and other fields.

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Section: Resultsmentioning

confidence: 99%

Plasma-Excited Nebulizer Gas-Assisted Electrospray Ionization: Enhancing the Sensitivity of Pesticide in Mass Spectrometry

Bao,

Bai,

Wang

et al. 2023

Anal. Chem.

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“…30−33 Ambient electric arc ionization and direct analysis in real time (DART) realized analysis of quinolones and benzodiazepines in salts solutions directly. 34,35 However, when the analytes exist in more complex matrices, background interference became more laborious and difficult to overcome. 36 Therefore, there is a necessity to develop a method with a convenient device that can tolerate high salts and complex matrices to realize rapid detection of drugs.…”

mentioning

confidence: 99%

“…There are some methods that achieved satisfactory rapid detection of drugs. Dielectric barrier discharge ionization (DBDI) combined with nanometer metal probe, and desorption corona beam ionization (DCBI) were applied on the detection of antimicrobials in organisms and animal-derived foods, respectively. − Ambient electric arc ionization and direct analysis in real time (DART) realized analysis of quinolones and benzodiazepines in salts solutions directly. , However, when the analytes exist in more complex matrices, background interference became more laborious and difficult to overcome . Therefore, there is a necessity to develop a method with a convenient device that can tolerate high salts and complex matrices to realize rapid detection of drugs. − …”

mentioning

confidence: 99%

Crystallization and Solvent Evaporation Ionization Mass Spectrometry (CSEI-MS) for Rapid Detection of Drugs in Complex Matrices

Chen,

Li,

Luo

et al. 2024

Anal. Chem.

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Illegal addition of drugs is common but seriously threatens public health safety. Conventional mass spectrometry methods are difficult to realize direct analysis of drugs existing in some complex matrices such as seawater or soil due to the ion suppression effect and contamination to MS parts caused by nonvolatile salts. In this work, a novel crystallization and solvent evaporation ionization mass spectrometry (CSEI-MS) method was constructed and developed to achieve rapid desalting detection. CSEI only consists of a heated plate and a nebulizer and exhibits excellent desalting performance, enabling direct analysis of six drugs dissolved in eight kinds of salt solutions (up to 200 mmol/L) and three complex salty matrices. Under optimized conditions, CSEI-MS presents high sensitivity, accuracy, linearity, and intraday and interday precision. Finally, this method is applied to the quantitative analysis of drugs in seawater, hand cream, and soil. Furthermore, the highly sensitive detection of CSEI-MS is demonstrated to remain even if the detection processes are conducted within 5 s via common commercial tools.

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Tip-assisted ambient electric arc ionization mass spectrometry for rapid detection of trace organophosphorus pesticides in strawberry

Gao

Chu

et al. 2022

Chinese Chemical Letters

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Applications of ambient electric arc ionization mass spectrometry in saline samples

Cited by 6 publications

References 33 publications

Plasma-Excited Nebulizer Gas-Assisted Electrospray Ionization: Enhancing the Sensitivity of Pesticide in Mass Spectrometry

Plasma-Excited Nebulizer Gas-Assisted Electrospray Ionization: Enhancing the Sensitivity of Pesticide in Mass Spectrometry

Crystallization and Solvent Evaporation Ionization Mass Spectrometry (CSEI-MS) for Rapid Detection of Drugs in Complex Matrices

Tip-assisted ambient electric arc ionization mass spectrometry for rapid detection of trace organophosphorus pesticides in strawberry

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