Arbutin: Isolation, X-ray structure and computional studies

Nycz, Jacek E.; Małecki, Jan Grzegorz; Morąg, Monika; Nowak, Gerard; Ponikiewski, Łukasz; Kusz, Joachim; Świtlicka, A.

doi:10.1016/j.molstruc.2010.06.026

Cited by 23 publications

(25 citation statements)

References 15 publications

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“…The first reduction potential corresponds with the electrochemical behaviour of natural occurring quinones [1][2][3]28]. In a broader sense it also highlights the possible role of electron transfer in the biological activity of naturally occurring quinolinediones such as lavendamycin [8].…”

Section: Cyclic Voltammetrymentioning

confidence: 84%

Synthesis, spectroscopy and computational studies of some novel phosphorylated derivatives of quinoline-5,8-diones

Nycz

Malecki

Ponikiewski

et al. 2011

Journal of Molecular Structure

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Section: Cyclic Voltammetrymentioning

confidence: 84%

Synthesis, spectroscopy and computational studies of some novel phosphorylated derivatives of quinoline-5,8-diones

Nycz

Malecki

Ponikiewski

et al. 2011

Journal of Molecular Structure

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“…VI) for the treatment of urogenital tract infections. The theory of antibacterial properties of arbutin were formulated by Lewin already in 1883 (Dingermann et al, 2004;European Pharmacopoeia, 2008;Evans, 2009;Hänsel et al, 1999;Nycz et al, 2010;Polish Pharmacopeia, 2002, 2008Wichtl, 2004).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Arbutin and Hydroquinone in Different Plant Materials by HPLC

Rychlińska¹,

Nowak²

2012

Not Bot Hort Agrobot Cluj

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A simple, fast method of high-performance liquid chromatography for the determination and quantification of arbutin and hydroquinone in many different raw materials was developed and validated. The optimum conditions for the separation and detection of these two constituents were achieved on a LiChro-CARD 125-4 Superspher®100 RP-18 column with the water-methanol (gradient elution) mobile phase and recorded at 289 nm. The purities of peaks were verified by PDA analysis of impurities. The results of validation have shown that the HPLC method is stable and accurate for the simultaneous determination of arbutin and hydroquinone in extracts from various plants. The developed method gave a good sensitivity (LOD 1µg/ml for arbutin and 0.49 µg/ml for hydroquinone) with linearity R 2 >0.9993 (for both). The relative standard deviation of the method was less than 2.53% for intra-day assays and 3.23% for inter-day assay, the accuracy of the recovery test ranged from 98.96% to 106.4%. This method was used in comparative qualitative analysis of arbutin and hydroquinone in 16 different raw materials from families Lamiaceae, Ericacaeae, Saxifragaceae, Rosaceae. The content of arbutin in B. ciliata, B. cordifolia and Ledum palustre was examined for the first time.

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“…The NMR data of compounds 1 and 2 are in agreement with reported data. 34,35 Annexin assay MDA-MB-231 breast cancer cells exposed to TdM for 24 h were positive to Annexin V (PE) and 7AAD, indicating that they were in the latter stages of apoptosis. The percentage of these cancer cells stained with Annexin V (+) was 22.6% for those treated with TdM, 22.4% for those treated with doxorubicin (the positive control), and 13.5% for those treated with DMSO (the negative control) (Figs.…”

Section: Bioassay-guided Fractionationmentioning

confidence: 99%

Cytotoxic Activity of the Methanolic Extract of Turnera diffusa Willd on Breast Cancer Cells

Avelino-Flores

Cruz-López

Jiménez-Montejo

et al. 2015

Journal of Medicinal Food

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Turnera diffusa Willd, commonly known as Damiana, is employed in traditional medicine as a stimulant, aphrodisiac, and diuretic. Its leaves and stems are used for flavoring and infusion. Damiana is considered to be safe for medicinal use by the FDA. Pharmacological studies have established the hypoglycemic, antiaromatase, prosexual, estrogenic, antibacterial, and antioxidant activity of T. diffusa. The aim of the present study was to evaluate the possible cytotoxic effect of extracts and organic fractions of this plant on five tumor cell lines (SiHa, C-33, Hep G2, MDA-MB-231, and T-47D) and normal human fibroblasts. The results show that the methanolic extract (TdM) displayed greater activity on MDA-MB-231 breast cancer cells (with an IC50 of 30.67 μg/mL) than on the other cancer cell lines. Four organic fractions of this extract exhibited activity on this cancer cell line. In the most active fraction (F4), two active compounds were isolated, arbutin (1) and apigenin (2). This is the first report of a cytotoxic effect by T. diffusa on cancer cells. The IC50 values suggest that the methanolic extract of T. diffusa has potential as an anticancer therapy.

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Arbutin: Isolation, X-ray structure and computional studies

Cited by 23 publications

References 15 publications

Synthesis, spectroscopy and computational studies of some novel phosphorylated derivatives of quinoline-5,8-diones

Synthesis, spectroscopy and computational studies of some novel phosphorylated derivatives of quinoline-5,8-diones

Quantitative Determination of Arbutin and Hydroquinone in Different Plant Materials by HPLC

Cytotoxic Activity of the Methanolic Extract of Turnera diffusa Willd on Breast Cancer Cells

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