Arboviruses emerging in Peru: Need for early detection of febrile syndrome during El Niño episodes

Tantaléan-Yépez, Derek; Sánchez-Carbonel, José; Ulloa-Urizar, Gabriela; Aguilar-Luis, Miguel Ángel; Espinoza-Morales, Diego; Silva-Caso, Wilmer; Pons, María J.; Valle-Mendoza, Juana del

doi:10.1016/j.apjtm.2016.06.018

Cited by 4 publications

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“…However, only DENV, CHIKV and ZIKV are notifiable diseases in Peru, and less than 50% of samples can be confirmed by the Instituto Nacional de Salud , the only Laboratory in Peru designated for Epidemiological Surveillance [ 8 , 24 , 25 ]. This passive National surveillance strategy coupled with the diagnostic barriers in the rural areas have led to an underestimation of cases of arboviruses in the Peruvian Amazon Basin [ 1 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Emerging and reemerging arboviruses: A new threat in Eastern Peru

et al. 2017

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BackgroundArboviral diseases are one of the most common causes of acute febrile illness (AFI) and a significant health problem in South America. In Peru, laboratory etiologic identification of these infections occurs in less than 50% of cases, leading to underdiagnoses of important emerging arboviruses.AimTo assess the prevalence of the Dengue (DENV), Oropouche (OROV), Chikungunya (CHIKV), Mayaro (MAYV) and Zika (ZIKV) viruses in patients with acute febrile illness from Puerto Maldonado (Peru).MethodologySerum samples were obtained from patients with AFI during January 2016 to March 2016. A total of 139 specimens were analyzed for the presence of DENV, OROV, CHIKV, MAYV, and ZIKV using polymerase chain reaction (PCR).ResultsCHIKV in 9.4% and OROV in 8.6% were the most prevalent arboviruses, followed by DENV and ZIKV, with a prevalence of 6.5% and 5%, respectively. Among all patients, the most common symptoms accompanying fever were headaches 79.9%, muscle pain 65.5% and joint pain 63.3%.ConclusionsDuring this short 3-month period, 4 arboviruses were detected by PCR, CHIKV and OROV being the most common arboviruses in Puerto Maldonado (Peru). Thus, it is crucial to include OROV detection in the national health surveillance. Furthermore, the etiologic clinical diagnosis of arboviral infections is not possible due to the low specificity of symptoms; therefore an increase of cases confirmed by molecular diagnostic methods will enhance arboviral surveillance in Peru.

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, ZIKV case definition is especially challenging during simultaneous DENV and CHIKV epidemics. [ 26 , 31 ]. Nonetheless, Peru is under a significant risk of a Zika and the detection of this virus in our series should raise awareness about the presence of the virus in our territories.…”

Section: Discussionmentioning

confidence: 99%

Emerging and reemerging arboviruses: A new threat in Eastern Peru

et al. 2017

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“…In addition, El Niño phenomenon has produced increased rainfall and rise in temperature resulting in more mosquito breeding grounds. These climate changes have severely affected the region becoming an important scenario from arboviral diseases; thus highlighting the necessity for early detection and confirmation of febrile syndromes etiologies [ 23 , 24 ]. The Peruvian epidemiological reports from July 2017 reveals that a total of 43,719 cases of dengue has been observed in the first half of the year in Piura, which represents the 64.8% of national cases.…”

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confidence: 99%

Identification of infection by Chikungunya, Zika, and Dengue in an area of the Peruvian coast. Molecular diagnosis and clinical characteristics

et al. 2018

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ObjectiveTo assess the presence of Dengue, Chikungunya, and Zika in serum samples of patients with acute febrile illness in Piura, Peru and describe the most common clinical features.ResultsDengue was the most common arbovirus detected in 170/496 (34.3%), followed by Zika in 39/496 (7.9%) and Chikungunya in 23/496 (4.6%). Among the 170 samples positive for Dengue, serotype 2 was the most predominant type present in 97/170 (57.1%) of samples, followed by the serotype 3 in 9/170 (5.3%). Headaches, muscle pain, and joint pain were the most common symptoms associated with fever in patients with Dengue and Zika. No symptoms predominance was observed in patients with Chikungunya.Dengue is considered the most frequent arbovirus in Peru and the number of cases has increased dramatically in the last 5 years. However, it is not the only arbovirus that circulates along the northern coast of Peru. It has also been determined the presence of Zika and Chikungunya in our population, which may suggest the circulation of other arboviruses that have not been detected.

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“…En los últimos años Perú ha sido catalogado como uno de los países con índices de dengue altos debido a que siempre está experimentando un aumento considerable del virus (DENV) y la presencia de las diferentes serovariedades que este presenta con el DENV-2 y DENV-3 (24). Lo que demuestra que hay una concordancia con la aparición de brotes en las regiones del estado peruano (6) (23).…”

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Estudio serotípico del virus del dengue y características clínicas en pacientes con enfermedad febril aguda

Rafael-Heredia

Iglesias-Osores

Zuñiga-Valdera

et al. 2023

Rev. Salud. Amaz. Bienestar.

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El objetivo del presente estudio fue determinar la frecuencia de los serotipos del virus Dengue (DENV) y describir su presentación clínica en pacientes con enfermedad febril aguda, enero-junio del 2020, Perú. De un total de muestras de suero de los centros de salud se estudió la presencia de DENV mediante RT-PCR, antígeno NS1 y anticuerpos IgM. Se usó un cuestionario estandarizado para recolectar la información de síntomas clínicos. Dentro de la evaluación de 496 pacientes con enfermedad febril aguda (AFI) y con dengue sospechosos se estudiaron, consecutivamente entre los meses de enero a junio. Dentro de los síntomas evaluados, 495 (99 %) pacientes entre mujeres y hombre presentaron fiebre y solo 1 persona lo contrario. Los siguientes síntomas fueron evaluados según la incidencia de casos: artralgias presentes en 372 (75 %) personas; mialgias en 340 (68,5 %), cefaleas en 341 (68,8 %), dolor ocular en 321 (64,7 %), dolor lumbar en 303 (61,1 %), rash extrema en 189 (38,1 %) presentando incidencia en adolescentes, cuadro de conjuntivitis en 92 (18,5 %) y náuseas en 185 (37,3 %). El diagnóstico de Dengue demostró que el NS1 y la IgM anti DENV tiene su sensibilidad y especifica válida.

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Arboviruses emerging in Peru: Need for early detection of febrile syndrome during El Niño episodes

Cited by 4 publications

References 5 publications

Emerging and reemerging arboviruses: A new threat in Eastern Peru

Emerging and reemerging arboviruses: A new threat in Eastern Peru

Identification of infection by Chikungunya, Zika, and Dengue in an area of the Peruvian coast. Molecular diagnosis and clinical characteristics

Estudio serotípico del virus del dengue y características clínicas en pacientes con enfermedad febril aguda

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