ObjectiveTo assess the presence of Dengue, Chikungunya, and Zika in serum samples of patients with acute febrile illness in Piura, Peru and describe the most common clinical features.ResultsDengue was the most common arbovirus detected in 170/496 (34.3%), followed by Zika in 39/496 (7.9%) and Chikungunya in 23/496 (4.6%). Among the 170 samples positive for Dengue, serotype 2 was the most predominant type present in 97/170 (57.1%) of samples, followed by the serotype 3 in 9/170 (5.3%). Headaches, muscle pain, and joint pain were the most common symptoms associated with fever in patients with Dengue and Zika. No symptoms predominance was observed in patients with Chikungunya.Dengue is considered the most frequent arbovirus in Peru and the number of cases has increased dramatically in the last 5 years. However, it is not the only arbovirus that circulates along the northern coast of Peru. It has also been determined the presence of Zika and Chikungunya in our population, which may suggest the circulation of other arboviruses that have not been detected.
Background: Arboviral diseases has reemerged in the last years affecting primarily the coast of Peru. Piura is a region endemic for arboviruses where Dengue (DENV), Chikungunya (CHIKV) and Zika (ZIKV) have been previously reported.The aim was assess the presence of DENV, CHIKV, and ZIKV in serum samples of patients with acute febrile illness from Piura, Peru and describe associated clinical features.Methods & Materials: A total of 496 serum samples from patients with acute febrile illness were collected from 18 primary care centers. All samples were analyzed via real-time RT-PCR to detect DENV, CHIKV, and ZIKV. In addition, positive samples for DENV were also processed for serotypes 1 to 4 classification via RT-PCR.Results: DENV was the most common arbovirus detected in 170/496 (34.3%), followed by ZIKV in 39/496 (7.9%) and CHIKV in 23/496 (4.6%). Among the 170 samples positive for DENV, serotype 2 was the most predominant type present in 97/170 (57.1%) of samples, followed by the serotype 3 in 9/170 (5.3%). Headaches, muscle pain, and joint pain were the most common symptoms associated with fever in patients with DENV and ZIKV. No symptoms predominance was observed in patients with CHIKV.
Conclusion:DENV is considered the most predominant arbovirus in Peru and the number of cases have dramatically increased in the last 3 years. DENV-2 and DENV-3 are the most common serotypes circulating in Piura. In contrast to national surveillance reports, a higher prevalence of ZIKV and CHIKV have been observed in our population.
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