Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell–mediated cytotoxicity against neuroblastoma in vitro and in vivo

Modified rice bran hemicellulose inhibits vascular endothelial growth factor-induced angiogenesis <i>in vitro</i> via VEGFR2 and its downstream signaling pathways

“…Our findings of the inhibitory effects of MRBH on VEGF-induced angiogenesis are in agreement with previous reports concerning the anti-tumor activity of MRBH [22, 25, 35,36,37]. The anti-angiogenic activity of MRBH could contribute to its tumor suppression effects, as well as its anti-inflammatory effects on humans with chronic rheumatism [30] and IBS [31] and on acute liver injury in rats [29].…”

“…Earlier studies indicated that MRBH exerts anti-tumor effects in animal models [22, 35, 36] and human patients [25, 37] through the enhancement of NK activity [20,21,22, 35], an increase in the T and B cell mitogen response [18], the augmentation of macrophage phagocytosis [23], and the promotion of dendritic cell maturation [24,25,26,27]. It was also shown to have anti-inflammatory effects, with observed protective actions in acute liver injury in rats [29] and improvement effects on chronic rheumatism [30] and IBS [31] in humans.…”

“…1.Main chemical structure of MRBH.) [18, 19]. Previous studies have demonstrated that MRBH has immunostimulatory effects, including enhancement of natural killer (NK) cell activity both in vitro and in vivo [20,21,22], increase of the T and B cell mitogen response [18], augmentation of macrophage phagocytosis [23], and promotion of dendritic cell (DC) maturation [24,25,26,27]. MRBH also protects against γ-irradiation-induced hematopoietic damage in mice [28] and has anti-inflammatory effects on D-galactosamine-induced hepatitis in rats [29] and chronic rheumatism [30] and irritable bowel syndrome (IBS) in humans [31].…”

Can a standardized plant immunomodulator (rice bran arabinoxylan concentrate/MGN-3) increase the effects of MEK and BRAF inhibitors with clinical benefit? Case report of a patient with carcinoma in biliary duct

“…Unfortunately, the best evidence based and standardized immunodulators without any side effects are plant extracts and they are all over the world registered only as food supplements. There are growing evidences that plant PAMP-like molecules (such as standardized rice bran arabinoxylan concentrate) exhibit a lot of immunological [15][16][17][18][19][20][21][22][23][24][25][26] and clinical benefit [27][28][29]. Therefore, further clinical trials are necessary to investigate this beneficial interaction.…”

Enzymatic Modification of Rice Bran Polysaccharides by Enzymes from Grifola Frondosa: Natural Killer Cell Cytotoxicity and Antioxidant Activity

“…() modified the water‐soluble polysaccharide RBPSs2a, which was purified from RB, with sulfates to obtain SRBPSs2a, and the anti‐tumor activity of the polysaccharide was higher after modification (Ray et al., ). One of the most widely studied modified polysaccharides, MGN‐3, which is mainly composed of arabinoxylan from RB, was modified using carbohydrate‐hydrolyzing enzymes extracted from shiitake mushrooms (Ghoneum, ; Pérezmartínez et al., ). MGN‐3 has been clinically proven to enhance depleted immune systems, making it an ideal food supplement for those whose immune systems are compromised by disease or toxic treatments (Cholujova et al., ; Ghoneum, Badr ElDin, Ali, & Eldein, ).…”