Aqueous pseudolatex of zein for film coating of solid dosage forms

O’Donnell, Patrick B.; Wu, Chuanbin; Wang, Jijun; Wang, Lisa; Oshlack, Benjamin; Chasin, Mark; Bodmeier, Roland; McGinity, James W.

doi:10.1016/s0939-6411(96)00013-6

Cited by 45 publications

(30 citation statements)

References 3 publications

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“…The crystallinity of ibuprofen is evidenced in the top photograph ( Figure 2A) while the amorphous state of the plasticized polymer is seen in the bottom photograph ( Figure 2C). This result is also in agreement with our previous findings [13], where the x -ray diffraction patterns from cast Eudragit RS 30 D films containing ibuprofen were found to be identical to those of the pure polymer, as the drug was dissolved or present in an amorphous state within the polymeric matrix.…”

Section: Resultssupporting

confidence: 93%

“…Generally, the smaller the difference in the solubility parameters between 2 compounds, the greater their miscibility will be. The difference in the solubility parameters is therefore a useful guide to the compatibility and miscibility of a plasticizer with a particular polymer [13,15] . Reports from the literature have suggested that in order to obtain good miscibility between 2 compounds, the difference in the solubility parameters should not be greater than 6.…”

Section: Resultsmentioning

confidence: 99%

“…Previous research has shown that ibuprofen functioned as a plasticizer for acrylic films. In that study, the concept of n ontraditional plasticization of acrylic polymer was introduced and ibuprofen and methylparaben were demonstrated to have a significant plasticization effect on Eudragit® RS 30 D [12][13][14] . The objectives of the present study were to investigate and characterize the drug release behavior and stability of beads coated with Eudragit RS 30 D containing ibuprofen as a multifunctional agent (active agent, plasticizer, and stabilizer) and to study the interaction between Eudragit RS 30 D and ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

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Influence of ibuprofen as a solid-state plasticizer in eudragit® RS 30 D on the physicochemical properties of coated beads

McGinity

2001

AAPS PharmSciTech

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The purpose of this study w as to investigate the physicochemical properties of nonpareil beads coated with Eudragit® RS 30 D containing ibuprofen as a multifunctional agent. The influence of the concentration of ibuprofen in the film coating and the effect of the coating level on drug release from coated beads was determined in pH 7.2 phosphate buffer solution. The influence of storage time at 23°C and 60°C on the release of ibuprofen from coated beads was also investigated. The thermal properties of the films were determined using a differential scanning calorimeter. Scanning electron microscopy was employed to image the surface morphology of the coated beads. Infrared spectroscopy was used to study the interaction of Eudragit RS 30 D and ibuprofen. Results from the dissolution studies demonstrated that increasing the amount of ibuprofen in the polymeric film reduced the rate of drug release, mainly because of a more complete coalescence of the polymeric particles of the latex dispersion. The glass transition temperature (Tg) of Eudragit RS 30 D films decreased and the surface of the coated beads became smoother as the concentration of ibuprofen was increased. Hydrogen bonding between the polymer and ibuprofen was demonstrated by Fourier transform infrared spectroscopy. No significant differences were found in drug dissolution between the coated beads stored at 23°C for 12 months and those stored at 60°C for 12 hours. The results of this study demonstrated that the ibuprofen plasticized the Eudragit RS 30 D. Furthermore, the dissolution rate of ibuprofen can be controlled and changes in the drug release rate can be minimized by using the druginduced plasticization technique with this polymer.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of ibuprofen as a solid-state plasticizer in eudragit® RS 30 D on the physicochemical properties of coated beads

McGinity

2001

AAPS PharmSciTech

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“…Reports concerning the application of zein in enteric coatings are somewhat contradictory O'Donnell et al, 1997). …”

Section: Fig 3 Structural Representation Of α-Zein (22kda) Amino Amentioning

confidence: 99%

“…A different formulation containing zein was developed by O'Donnell et al (1997). The paracetamol tablets were coated with zein dispersions containing propylene glycol as a plasticiser and methyl or propyl parabens as preservatives.…”

Section: Fig 3 Structural Representation Of α-Zein (22kda) Amino Amentioning

confidence: 99%