Influence of ibuprofen as a solid-state plasticizer in eudragit® RS 30 D on the physicochemical properties of coated beads

Abstract

The purpose of this study w as to investigate the physicochemical properties of nonpareil beads coated with Eudragit® RS 30 D containing ibuprofen as a multifunctional agent. The influence of the concentration of ibuprofen in the film coating and the effect of the coating level on drug release from coated beads was determined in pH 7.2 phosphate buffer solution. The influence of storage time at 23°C and 60°C on the release of ibuprofen from coated beads was also investigated. The thermal properties of the films were determined using a differential scanning calorimeter. Scanning electron microscopy was employed to image the surface morphology of the coated beads. Infrared spectroscopy was used to study the interaction of Eudragit RS 30 D and ibuprofen. Results from the dissolution studies demonstrated that increasing the amount of ibuprofen in the polymeric film reduced the rate of drug release, mainly because of a more complete coalescence of the polymeric particles of the latex dispersion. The glass transition temperature (Tg) of Eudragit RS 30 D films decreased and the surface of the coated beads became smoother as the concentration of ibuprofen was increased. Hydrogen bonding between the polymer and ibuprofen was demonstrated by Fourier transform infrared spectroscopy. No significant differences were found in drug dissolution between the coated beads stored at 23°C for 12 months and those stored at 60°C for 12 hours. The results of this study demonstrated that the ibuprofen plasticized the Eudragit RS 30 D. Furthermore, the dissolution rate of ibuprofen can be controlled and changes in the drug release rate can be minimized by using the druginduced plasticization technique with this polymer.

Improvement in Chemical and Physical Stability of Fluvastatin Drug Through Hydrogen Bonding Interactions with Different Polymer Matrices

“…A similar chemical stability of Nivaldipine was reported by using PVP and methyl cellulose drug carriers at accelerating conditions, while analogous were the results for physical stability [49]. Furthermore, Eudragit RS was proved that is also an effective carrier during storage of ibuprofen, since the dissolution rate was unaffected after 12 months of storage at 23°C [50]. No significant differences were found between the initial drug release rate and the dissolution profiles of the aged samples.…”

Glass transition temperature: Basics and application in pharmaceutical sector

“…[2] This results in polymer chains sliding past each other more easily. As a result, the polymer chains can move around at lower temperatures resulting in decrease in Tg of a polymer [2,13,[21][22][23] Example of plasticizer includes, nitrobenzene, β-naphthyl salicylate, carbon disulphide; [2] glycerine, [24][25][26][27] propylene glycol, [24,[26][27][28] triethyl citrate, [24,[27][28][29] triacetine, [24,27,30] polyethylene glycol, [31] etc. Water or moisture content Increase in moisture content leads to increase in free volume due to formation of hydrogen bonds with polymeric chains increasing the distance between polymeric chains.…”

Preparation and characterization of water-soluble microcapsule for sustained drug release using Eudragit RS 100

“…The stretching bands at 1160 and 1250 cm -1 of EuRS are attributed to the carbonyl stretching vibration of the ester group. 27 And, the peak at 2810 cm -1 is exhibited adsorption band of ammonium groups. The peaks of ondansetron at 3470 and 3350 cm -1 correspond to symmetric and asymmetric N-H stretching in primary amide group, respectively.…”