Aqueous Leaf Extract Of Rothmannia Longiflora Improves Basal Metabolic Rate And Electrolyte Parameters In Alloxan Induced Diabetic Rats

Ikpi, Daniel Ewa; Obembe, A; Nku, CO

doi:10.4314/njps.v24i1.46386

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…However, on day-22 this level was significantly lower in DG-A-P in comparison to that of DC-A. Similar finding was also observed by different researchers by using different herbal plants 13,15 . In DC-A fasting blood glucose level was significantly higher from day-1 to day-3 (p<0.05) and then to day-22.…”

Section: Discussionsupporting

confidence: 87%

Effect of Peanut (Arachis hypogaea L.) on Fasting Blood Glucose and HbA1c in Alloxan Induced Diabetic Male Rats

Akter

Jahan

Sultana³

2015

J Bangladesh Soc Physiol

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Background: Diabetes mellitus (DM) is a heterogeneous group of metabolic disorders with micro and macrovascular complications which are the major causes of morbidity and mortality in diabetic patients. Peanut due to its anti-oxidant property can reduce blood glucose level and may reduce the risk of diabetes. Objective: To observe the anti-diabetic effects of peanut (Arachis hypogaea L.) in alloxaninduced diabetic male rats. Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka in 2013. For this purpose, 15 wistar albino male rats, aged 90-120 days, weighing 160-200 g (initial body weight) were included in the experimental group (DG-A-P). Age and weight matched 20 wistar albino rats without peanut supplementation was taken as control and divided into (BC and DC-A) . All groups of animals received basal diet for 21 consecutive days. In addition to basal diet, animals of DC-A received alloxan intraperitoneally only on the first day of the study. Moreover, animals of DG-A-P also received peanut extract for 21 consecutive days. After 16 hours of fasting blood samples were collected from tail vein of all rats on day-1 and day- 3. After taking final body weight all the rats were sacrificed on 22nd day. Their pancreas was removed and weighed. To observe glycemic control serum blood glucose and blood HbA1c levels were measured by usual laboratory technique. ANOVA, independent t-test and paired t-test were used for statistical analysis. Result: The % change of body weight was significantly (p<0.001) lower in DC-A in comparison to that of BC. The weight of pancreas was significantly lower in DC-A (p<0.001) and DG-A-P (p<0.05) when compared to that BC, whereas this level was significantly higher (p<0.001) in DG-A-P than that of DC-A. The mean fasting blood glucose level on day-3 was significantly (p<0.001) higher in DC-A and DG-A-P in comparison to that of BC. Then this level was significantly (p<0.001) lower in DG-A-P in comparison to that of DC-A on day-22. Moreover, significantly higher levels of HbA1c were observed in DC-A (p<0.001) and DG-A-P (p<0.05) in comparison to those of BC. Again, significantly (p<0.001) lower level of blood HbA1c were observed in DG-A-P than those of DC-A. Conclusion: From this study, it can be concluded that peanut (Arachis hypogaea L.) has anti-diabetic effect by reducing fasting blood glucose, HbA1c levels. This anti-diabetic effect may be due to its high MUFA content and anti-oxidant property. DOI: http://dx.doi.org/10.3329/jbsp.v9i2.22796 Bangladesh Soc Physiol. 2014, December; 9(2): 48-53

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Section: Discussionsupporting

confidence: 87%

Effect of Peanut (Arachis hypogaea L.) on Fasting Blood Glucose and HbA1c in Alloxan Induced Diabetic Male Rats

Akter

Jahan

Sultana³

2015

J Bangladesh Soc Physiol

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“…Atangwho et al (2009) reported that the serum concentrations of Na and K of STZ-diabetic rats were decreased compared to the non-diabetic control. Ikpi et al (2009) demonstrated that the level of serum Na was significantly decreased in alloxan-induced diabetic rats, while the level of K was statistically unchanged compared with control rats. Akah et al (2009) showed that the level of serum Na was significantly unchanged in alloxan-induced diabetic rats, while the level of K was statistically increased compared with control rats.…”

Section: Discussionmentioning

confidence: 88%

Physiological Study on the Effect of Acalypha wilkesiana Leaves Extract on Streptozotocin-Induced Experimental Diabetes in Male Mice

Al-Attar¹

2010

American Medical Journal

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Problem statement: Diabetes mellitus is a chronic disease that causes serious health complications and it is now one of the most common non-communicable diseases globally. It is the fourth or fifth leading cause of death in most high-income countries and there is substantial evidence that it is epidemic in many economically developing and newly industrialized nations. Recently, there has been a growing interest in antidiabetic agents from natural products especially those derived from plants. The antidiabetic agents have been focused on plants used in traditional medicine because that may be a better treatment than currently used synthetic drugs. Approach: The influence of Acalypha wilkesiana leaves extract on the levels of serum glucose, triglycerides, cholesterol, sodium (Na), potassium (K) and Calcium (Ca) was investigated using Streptozotocin (STZ)-induced diabetic mice. Diabetes was induced in male albino mice by single intraperitoneal injection of STZ (60 mg kg −1 body weight). The experimental animals were divided into four groups.The first group was untreated and served as normal control. The mice of second group were used as diabetic control group. The diabetic mice of third group were treated orally with A. wilkesiana leaves extract for 30 days. The normal mice of fourth group were treated orally with A. wilkesiana leaves extract at the same dose given to third group. Results: The diabetic mice showed significant increases in the levels of serum glucose, triglycerides, cholesterol and Na after 10, 20 and 30 days. Also, the level of K was statistically increased after 20 and 30 days, while the level of Ca was significantly elevated after 30 days. The diabetic mice given A. wilkesiana leaves extract showed significant decreases in the levels of serum glucose, cholesterol and K. Insignificant alterations in the values of serum triglycerides, Na and Ca were noted in diabetic mice treated with leaves extract at all periods of experiment. Conclusion/Recommendations: These new data indicate that A. wilkesiana represents an effective antihyperglycemic, antihyperlipidemic adjunct and ameliorative role on electrolytes disturbances for the treatment of diabetes and a potential source of discovery of new therapeutic agent.

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“…Electrolyte imbalance occurs in diabetic patients from insulin deficiency, hyperglycemia and hyperketonemia (Kitabchi et al, 2006). In uncontrolled diabetes, kidney function is compromised (Ikpi et al, 2009) with renal loss of electrolytes due to osmotic diueresis (Eteng et al, 2008). This study observed reduction of plasma K + , Na + and HCO3 _ and on the contrary, elevation of Clconcentrations in diabetic rats.…”

Section: Discussionmentioning

confidence: 54%

Hepatic- and Renal protective Effects of Chrysophyllum albidum (African Star Apple) Fruit-Skin Supplementation on Streptozotocin-Induced Diabetic Rats

2020

JNSR

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Chrysophyllum albidum commonly called African star apple, has been reported for its antidiabetic potential but its effect on liver and kidney functions in diabetic rats has not been well investigated. This study investigated effects of Chrysophyllum albidum fruit-skin (CAFS) supplemented diet on Streptozotocin-induced diabetic rats. Diabetes was induced intraperitonealy at a single dose of 50mg/kg bw of Streptozotocin (STZ). Forty male Wistar rats weighing averagely 170g were randomly divided into four groups of ten rats each; Group 1-Normal control, Group 2-Diabetic control, Group 3-Diabetic rats treated Glibenclamide, Group 4-Diabetic rats treated 70g/kg CAFS supplemented diet. After four weeks of treatment, the rats were sacrificed. Liver function biomarkers (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP)) activities, kidney function biomarkers (Creatinine and Urea), electrolyte ions (K + , Na + , HCO3and Cl-), total protein and bilirubin levels were measured in the plasma. The diabetic control exhibited hepato-renal dysfunction with significant (p<0.05) increase in the liver marker enzymes' activities, total bilirubin, creatinine and urea concentrations while decreasing total protein, albumin and electrolyte ions levels compared with normal control group. Treatment with CAFS supplemented diet significantly (p<0.05) enhanced liver and kidney recovery by reducing the elevated activities of liver marker enzymes, reversed the increments in creatinine, urea and total bilirubin while increasing the concentration of total protein and restoring electrolyte ions concentrations to near normal values. CAFS supplemented diet has hepatic-and renal protective effects on STZ-induced diabetic rats. Thus, CAFS could be considered as therapeutic agent against the progression of diabetes complications.

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Aqueous Leaf Extract Of Rothmannia Longiflora Improves Basal Metabolic Rate And Electrolyte Parameters In Alloxan Induced Diabetic Rats

Cited by 6 publications

References 9 publications

Effect of Peanut (Arachis hypogaea L.) on Fasting Blood Glucose and HbA1c in Alloxan Induced Diabetic Male Rats

Effect of Peanut (Arachis hypogaea L.) on Fasting Blood Glucose and HbA1c in Alloxan Induced Diabetic Male Rats

Physiological Study on the Effect of Acalypha wilkesiana Leaves Extract on Streptozotocin-Induced Experimental Diabetes in Male Mice

Hepatic- and Renal protective Effects of Chrysophyllum albidum (African Star Apple) Fruit-Skin Supplementation on Streptozotocin-Induced Diabetic Rats

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