Aquaculture trials for the production of biologically active metabolites in the New Zealand sponge Mycale hentscheli (Demospongiae: Poecilosclerida)

Page, Michael; Northcote, Peter T.; Webb, Victoria L.; Mackey, Steven; Handley, Sean J.

doi:10.1016/j.aquaculture.2005.04.069

Cited by 76 publications

(95 citation statements)

References 54 publications

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“…It would also be important to begin a pharmacokinetic/pharmacodynamic study on peloruside in both human cell lines and mouse models of cancer, before moving into phase I clinical trials. Advancement of peloruside into clinical trials is currently restricted by limited access to the natural product (34,35) and the lack of availability of a scaled-up synthesis to produce clinically relevant amounts of peloruside. Efforts are currently under way to address this problem of supply.…”

Section: Discussionmentioning

confidence: 99%

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

Meyer

Krauth

Wick³

et al. 2015

Molecular Cancer Therapeutics

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Peloruside A is a microtubule-stabilizing agent isolated from a New Zealand marine sponge. Peloruside prevents growth of a panel of cancer cell lines at low nanomolar concentrations, including cell lines that are resistant to paclitaxel. Three xenograft studies in athymic nu/nu mice were performed to assess the efficacy of peloruside compared with standard anticancer agents such as paclitaxel, docetaxel, and doxorubicin. The first study examined the effect of 5 and 10 mg/kg peloruside (QDÂ5) on the growth of H460 non-small cell lung cancer xenografts. Peloruside caused tumor growth inhibition (%TGI) of 84% and 95%, respectively, whereas standard treatments with paclitaxel (8 mg/kg, QDÂ5) and docetaxel (6.3 mg/kg, Q2DÂ3) were much less effective (%TGI of 50% and 18%, respectively). In a second xenograft study using A549 lung cancer cells and varied schedules of dosing, activity of peloruside was again superior compared with the taxanes with inhibitions ranging from 51% to 74%, compared with 44% and 50% for the two taxanes. A third xenograft study in a P-glycoprotein-overexpressing NCI/ADR-RES breast tumor model showed that peloruside was better tolerated than either doxorubicin or paclitaxel. We conclude that peloruside is highly effective in preventing the growth of lung and P-glycoprotein-overexpressing breast tumors in vivo and that further therapeutic development is warranted.

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Section: Discussionmentioning

confidence: 99%

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

Meyer

Krauth

Wick³

et al. 2015

Molecular Cancer Therapeutics

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“…On the negative side, the inherent unpredictability of marine environments can create problems (e.g., due to atypical climatic conditions or storm damage) (439) which are easily avoided in controlled in vitro systems. The outcomes of sponge aquaculture trials have varied widely, with success dependent upon a number of factors, including the type of farming structure (84,85,132), sponge growth form (86), farming location (271), and season of transplantation (86,87). If sponge survival can be ensured, then growth increases of up to 5000% per year (relative to the starting size) are achievable, depending on the sponge species examined (271).…”

Section: Methods For Accessing the Hidden Chemistry Of Marine Spongesmentioning

confidence: 99%

“…A New Zealand consortium, working together with a U.S. pharmaceutical company, is currently investigating whether cost-effective, industrial-scale synthesis is achievable (137). An alternative supply option for peloruside A is being explored by the same group, with aquaculture of M. hentscheli looking highly encouraging (137,271). With 200 kg of sponge yielding a mere 2 g of pure peloruside A, scaling-up is a priority, with the goal of growing Ͼ500 kg of sponge over the coming year (137).…”

Section: Biologically Active Chemicals From Marine Sponge-microbe Conmentioning

confidence: 99%

Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential

Taylor

Radax

Steger

et al. 2007

Microbiol Mol Biol Rev

1,273

1,512

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SUMMARY Marine sponges often contain diverse and abundant microbial communities, including bacteria, archaea, microalgae, and fungi. In some cases, these microbial associates comprise as much as 40% of the sponge volume and can contribute significantly to host metabolism (e.g., via photosynthesis or nitrogen fixation). We review in detail the diversity of microbes associated with sponges, including extensive 16S rRNA-based phylogenetic analyses which support the previously suggested existence of a sponge-specific microbiota. These analyses provide a suitable vantage point from which to consider the potential evolutionary and ecological ramifications of these widespread, sponge-specific microorganisms. Subsequently, we examine the ecology of sponge-microbe associations, including the establishment and maintenance of these sometimes intimate partnerships, the varied nature of the interactions (ranging from mutualism to host-pathogen relationships), and the broad-scale patterns of symbiont distribution. The ecological and evolutionary importance of sponge-microbe associations is mirrored by their enormous biotechnological potential: marine sponges are among the animal kingdom's most prolific producers of bioactive metabolites, and in at least some cases, the compounds are of microbial rather than sponge origin. We review the status of this important field, outlining the various approaches (e.g., cultivation, cell separation, and metagenomics) which have been employed to access the chemical wealth of sponge-microbe associations.

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“…This indicates that no cytotoxic activity could be a candidate of whether antineoplastic or anticancer compounds [10].…”

Section: Discussionmentioning

confidence: 99%

Extraction and Characterization of Bioactive Compounds from Cultured and Natural Sponge, Haliclona molitba and Stylotella aurantium Origin of Indonesia

Hutagalung¹,

Victor²,

Karjadidjaja³

et al. 2014

IJBBB

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Abstract-Soft-body invertebrates, such as sponges are physically-weak organisms; however they mostly survive for thousands of years. This is due to the fact that they are capable of defending themselves from predators by releasing toxic substances as their secondary metabolites against the predators. These compounds are highly potent for medicine such as anti-microbial, anti-cancer, and anti-inflammatory activities. A large quantity of sponges are needed to produce bioactive compounds as their secondary metabolites only could get in small amount. This could provoke the sea-sponges overexploitation. Cultured sponges could be the one of the alternatives to prevent excessive natural sea-sponge exploitation. However, it is still unclear whether the cultured sponge has similar bioactivity compare to the natural sponge as well. The purposes of this research were to extract secondary metabolites from natural and cultured sea-sponges (Haliclona molitba and Stylotella aurantium), and to evaluate their antimicrobial, hemolysis, and hemagglutination activities with differentiation (?) on cultured and natural sponges. Aquadest and methanol were used as solvents on this research. Methods were used to determine the antimicrobial activity using the round disc diffusion. Hemolysis and hemagglutination assays utilized red blood from Deutsch Democratic Yokohama (DDY) mice. Hemagglutination and hemolysis results were measured with a microplate reader. The extraction yield of natural sponge was not significantly different from cultured one. The aqueous extract resulted in higher yield than methanolic extract. As antimicrobial activity, Bacillus cereus was the most sensitive against the crude extracts either from the natural and cultured sponges among all tested bacteria. Although both types of sponges did not show hemolysis activity, they showed hemogglutination activity.

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Aquaculture trials for the production of biologically active metabolites in the New Zealand sponge Mycale hentscheli (Demospongiae: Poecilosclerida)

Cited by 76 publications

References 54 publications

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential

Extraction and Characterization of Bioactive Compounds from Cultured and Natural Sponge, Haliclona molitba and Stylotella aurantium Origin of Indonesia

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