Aptamer-Functionalized Fluorescent Silica Nanoparticles for Highly Sensitive Detection of Leukemia Cells

Tan, Juntao; Yang, Nuo; Hu, Zixi; Su, Jing; Zhong, Jian‐Hong; Yang, Yang; Yu, Yating; Zhu, Jianmeng; Xue, Dabin; Huang, Yingying; Lai, Zongqiang; Huang, Yong; Lü, Xiaoling; Zhao, Yongxiang

doi:10.1186/s11671-016-1512-8

Cited by 50 publications

(34 citation statements)

References 35 publications

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“…These results reflect the established ability of Sgc8 aptamer to target leukemia cells [20]. Sgc8 recognizes PTK-7 on the surface of CEM cells [18], recruiting nanoparticles to the surface and thereby making their uptake more efficient [23]. Our results suggest that Sgc8-MSN/Dox may target PTK-7-expressing cancer cells at primary as well as secondary sites or in circulation, making it useful for controlling metastasis.…”

Section: Dox Release From Sgc8-msn/dox In Vitrosupporting

confidence: 71%

“…We have designed a Sgc8 aptamer-modified fluorescent silica nanoparticles system (Sgc8-FSNPs) for detecting leukemia cells with high sensitivity and specificity, which prove useful not only for the diagnosis of leukemia but also for the targeted delivery of anti-leukemia drugs [18]. Based on this work, in the present study, we encapsulated doxorubicin (Dox) in MSNs, which we decorated with Sgc8 ( Fig.…”

Section: Introductionmentioning

confidence: 99%

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An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

et al. 2019

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How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on the tumor-targeting ability of the aptamer Sgc8 to deliver doxorubicin (Dox) to leukemia cells in a targeted way, thereby improving therapeutic efficacy and reducing toxicity. In this work, Sgc8-MSN/Dox showed sustained Dox release, and they targeted and efficiently killed CCRF-CEM human acute T lymphocyte leukemia cells, suggesting potential as a cancer therapy.

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Section: Dox Release From Sgc8-msn/dox In Vitrosupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

et al. 2019

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“…Zhao and colleagues developed aptamer-modified fluorescent silica NPs (FSNPs) by conjugating amine-labeled Sgc8 aptamer to carboxyl-modified FSNPs via amide coupling to detect leukemia cells. 26 They assessed the sensitivity and specificity of Sgc8-FSNPs using flow cytometry and fluorescence microscopy. The results showed that Sgc8-FSNPs could be used to accurately detect leukemia cells with high sensitivity, which indicated that Sgc8-FSNPs were a highly sensitive tool for specific detection of leukemia cells.…”

Section: Use Of Aptamers In Theranosticsmentioning

confidence: 99%

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Guan¹,

Zhang²

2020

IJN

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Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery.

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“…88 Fluorescent SiO 2 NPs can also be conjugated to an aptamer for CTC detection. One detection method of leukemia cells using aptamer-modified fluorescent SiO 2 NPs was presented by Tan et al 89 Due to selection of specific aptamers, this method could be adaptable to other types of cancer. Additionally, aptamer-NP conjugation can be advanced for drug-delivery applications.…”

Section: Magnetic-optical Bifunctional Nanoparticlesmentioning

confidence: 99%

<p>Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives</p>

Gribko

Künzel

Wünsch

et al. 2019

IJN

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Circulating tumor cells (CTCs) are disseminated cancer cells. The occurrence and circulation of CTCs seem key for metastasis, still the major cause of cancer-associated deaths. As such, CTCs are investigated as predictive biomarkers. However, due to their rarity and heterogeneous biology, CTCs’ practical use has not made it into the clinical routine. Clearly, methods for the effective isolation and reliable detection of CTCs are urgently needed. With the development of nanotechnology, various nanosystems for CTC isolation and enrichment and CTC-targeted cancer therapy have been designed. Here, we summarize the relationship between CTCs and tumor metastasis, and describe CTCs’ unique properties hampering their effective enrichment. We comment on nanotechnology-based systems for CTC isolation and recent achievements in microfluidics and lab-on-a-chip technologies. We discuss recent advances in CTC-targeted cancer therapy exploiting the unique properties of nanomaterials. We conclude by introducing developments in CTC-directed nanosystems and other advanced technologies currently in (pre)clinical research.

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Aptamer-Functionalized Fluorescent Silica Nanoparticles for Highly Sensitive Detection of Leukemia Cells

Cited by 50 publications

References 35 publications

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

<p>Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives</p>

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