An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

Yang, Yang; Zhao, Weihua; Tan, Wenwen; Lai, Zongqiang; Fang, Dong; Jiang, Lei; Chen, Zuo; Yang, Nuo; Lai, Yongrong

doi:10.1186/s11671-019-3208-3

Cited by 43 publications

(35 citation statements)

References 31 publications

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“…Incubation of aptamer-modified and bare NPs with MCF-7 cells (that overexpress MUC-1 protein) showed higher uptake levels of aptamer-functionalized NPs when compared to the bare NPs. Further examples of aptamers as ligand for active uptake are reported by Gui et al (2019) and Yang et al (2019b). Yang et al (2019b) modified the surface of mesoporous silica nanoparticles (MSNs) with Sgc8 aptamer able to bind protein tyrosine kinase-7 (PTK-7) on human acute T lymphocyte leukemia cells.…”

Section: Active Uptakementioning

confidence: 99%

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Sanità

Carrese

Lamberti

2020

Front. Mol. Biosci.

314

147

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The use of nanoparticles (NP) in diagnosis and treatment of many human diseases, including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the uptake efficiency significantly limit their use in clinical practice. The physico-chemical properties of NPs including surface composition, superficial charge, size and shape are considered the key factors that affect the biocompatibility and uptake efficiency of these nanoplatforms. Thanks to the possibility of modifying physico-chemical properties of NPs, it is possible to improve their biocompatibility and uptake efficiency through the functionalization of the NP surface. In this review, we summarize some of the most recent studies in which NP surface modification enhances biocompatibility and uptake. Furthermore, the most used techniques used to assess biocompatibility and uptake are also reported.

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Section: Active Uptakementioning

confidence: 99%

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Sanità

Carrese

Lamberti

2020

Front. Mol. Biosci.

314

147

View full text Add to dashboard Cite

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“…Besides, Sweeney et al have attached a bladder-cancer specific peptide named Cyc6 to MSN for active targeting [ 130 ]. Apart from small molecules, peptides and antibodies, the synthetic single-stranded DNA or RNA oligonucleotides (aptamers) have been used to decorate MSN for targeting cancer cells [ 131 , 132 ]. Moreover, Nguyen et al have shown the Toll-like receptor 9 mediated delivery of mesoporous silica cancer vaccine (antigen) to the dendritic cells (the body’s most professional antigen presenting cells) [ 133 ].…”

Section: Surface Modification Of Msn For Passive and Active Targetmentioning

confidence: 99%

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Barui

Cauda

2020

Pharmaceutics

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The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

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“…This approach led to the intracellular accumulation of doxorubicin and restored the sensitivity of breast cancer cells to doxorubicin [56]. In a recent work, Yang and colleagues [57] used mesoporous silica NPs (MSNPs), which are internalized by endocytosis, to target a human acute lymphoblastic leukemia (ALL) cell line. MSNPs were loaded with doxorubicin, and their surface was decorated with aptamer Sgc8, which specifically recognizes the protein tyrosine kinase-7 (PTK-7) on the membrane of ALL cells [57].…”

Section: Use Of Nanoparticles For Redox-controlled Drug Deliverymentioning

confidence: 99%

“…In a recent work, Yang and colleagues [57] used mesoporous silica NPs (MSNPs), which are internalized by endocytosis, to target a human acute lymphoblastic leukemia (ALL) cell line. MSNPs were loaded with doxorubicin, and their surface was decorated with aptamer Sgc8, which specifically recognizes the protein tyrosine kinase-7 (PTK-7) on the membrane of ALL cells [57]. This system allows specific doxorubicin uptake by leukemia cells, and, as MSNPs release the drug slowly and preferentially under the acidic conditions, it results in sustained drug accumulation at tumor sites, thus enhancing the specific anticancer effect of doxorubicin.…”

Section: Use Of Nanoparticles For Redox-controlled Drug Deliverymentioning

confidence: 99%

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

et al. 2020

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Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are strongly addicted to the increased activity of scavenging pathways to maintain ROS below levels that produce macromolecular damage and engage cell death pathways. Consistent with this notion, tumor cells are more vulnerable than their normal counterparts to pharmacological treatments that increase ROS production and inhibit ROS scavenging. In the present review, we discuss the recent advances in the development of integrated anticancer therapies based on nanoparticles engineered to kill cancer cells by raising their ROS setpoint. We also examine nanoparticles engineered to exploit the metabolic and redox alterations of cancer cells to promote site-specific drug delivery to cancer cells, thus maximizing anticancer efficacy while minimizing undesired side effects on normal tissues.

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An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

Cited by 43 publications

References 31 publications

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

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