Applications of snake venoms in treatment of cancer

Shanbhag, Vagish Kumar L

doi:10.1016/s2221-1691(15)30344-0

Cited by 37 publications

(30 citation statements)

References 10 publications

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“…The 11 venoms were selected from two snake families: Elapidae (four species) and Viperidae (seven species). The geographical distribution of the three-finger neurotoxins (approximately 6-9 kDa) and phospholipases A 2 (13)(14)(15). In our study, intense bands appeared at around 15 kDa for all Elapidae venoms tested, which probably correspond to the phospholipases A 2 , as this class of proteins was clearly identified in these venoms in earlier studies (32-35).…”

Section: Discussionsupporting

confidence: 70%

“…Snake venoms are aqueous solutions containing peptides and proteins that affect the nervous, cardiovascular, and neuromuscular systems (9). Several snake venom components are used as lead molecules in the development of new active substances for the treatment of cardiovascular diseases (10,11), clotting disorders (12,13), cancer (14,15), or pain (16). Snake venoms and individual components isolated from snake venoms demonstrated antibacterial activity against several Gram-positive and Gram-negative bacteria (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of selected snake venoms on pathogenic bacterial strains

Boda

Mare

Szabó

et al. 2019

Revista Romana De Medicina De Laborator

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Snake venoms are aqueous solutions containing peptides and proteins with various biochemical, physiological, and pathophysiological effects. Several snake venom components are used as lead molecules in the development of new active substances for the treatment of cardiovascular diseases, clotting disorders, cancer or pain. Antibacterial activity has also been attributed to snake venoms and proteins isolated from snake venoms. This study provides information regarding the antibacterial activity of venoms obtained from various snake species from the Elapidae and Viperidae families. Minimum inhibitory and bactericidal concentrations of snake venoms were determined for three Gram-positive (Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 29213, and Methicillin-resistant Staphylococcus aureus ATCC 43300) and three Gram-negative (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and Pseudomonas aeruginosa ATCC 27853) pathogenic bacteria. The observed effects were correlated with the protein content of each venom, determined using SDS-PAGE analysis and comparison with data available in the literature. Our findings represent a starting point for the selection of snake venoms containing components with potential use as lead molecules in the development of new antibacterial agents, targeting multidrug resistant bacterial strains.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of selected snake venoms on pathogenic bacterial strains

Boda

Mare

Szabó

et al. 2019

Revista Romana De Medicina De Laborator

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“…Since the last decade, an alternative which was suggested was to use animal derived preparations (venom of snake, toad, scorpion, spider etc.) to combat many diseases like cancer, nerve disorder, viral diseases etc 18,19 . In our medicinal system CUD, an animal derived preparation, has been used as an antiseptic agent since time immemorial.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2017

IJPSR

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Inconsequential use of broad-spectrum antibiotics results in the evolution of multiple drug resistant pathogenic gram-negative bacterial strains which is a global health threat and is responsible for high morbidity and mortality rates. This necessitated the search for new effective and safe treatment strategies. One such successful treatment strategy is combination therapy which comprises cow urine distillate and medicinal plants extract. In the present report, this combination therapy was used against five pathogenic gram-negative bacteria-S. typhimurium, K. pneumoniae, E. coli, E. aerogenes and V. cholerae. It was observed that combination therapy had more profound effect than the individual plant extract against all the bacterial strains at the specified level. Combination therapy with T. erecta plant extract was found to be the most effective which improved the antibacterial effect 2.54 times more against E. coli. Other plants extract also improved their antibacterial potential when used with CUD (R.A.I=1.28 to 2.54). INTRODUCTION: Cell wall of gram-negative bacteria is more complex than gram-positive bacteria, due to an extra outer phospholipidic membrane carrying the lipopolysaccharide components, which makes the cell wall less permeable to antimicrobial substances. Evolution of multidrug-resistant gram-negative bacteria due to incongruous use of broad-spectrum antibiotics is responsible for the 30-70% mortality rate due to treatment failure of hospitalized patients.

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“…One of the alternatives suggested recently was use of animal derived preparations against many pathogens and disease, e.g. snake, toad, scorpion and spider's venom as curative agents used successfully against cancerous cells, nerve disease and various viral infections 18,19 . Nevertheless, CUD is being used in rural population as an antiseptic agent for wound infection and dermatitis since time immemorial.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

IJPSR

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Pathogenic bacterial infections are of serious clinical concern around the world. Indiscriminate use of antibiotics makes this situation beyond control. Hence, microbiologists are trying to find out the new and promising therapies against these bacterial infections. In the present research, combination therapy, which comprises extract of different medicinal plants and cow urine distillate, was used against six pathogenic gram positive bacteria. The efficacy of this combination therapy was evaluated by two methods: agar well diffusion method and XTT-colorimetric method. It has been demonstrated that CUD has profound synergistic effect on the efficacy of plants-derived extracts against the pathogenic bacteria at the specified level. The relative activity of different extracts with CUD as solvent medium was found to be increased (R.A.I= 1.61 to 2.13) against every bacteria of present study. MIC & MBC results were greatly improved (upto 2 to 3 folds) by the combination therapy. The results obtained in the present study could be useful for further research to assess the effect of combination therapy against other pathogenic microorganisms like fungi and viruses.

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Applications of snake venoms in treatment of cancer

Cited by 37 publications

References 10 publications

Antibacterial activity of selected snake venoms on pathogenic bacterial strains

Antibacterial activity of selected snake venoms on pathogenic bacterial strains

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