Applications of Fibrin-based products in Endodontics: A Literature Review

Bolhari, Behnam; Meraji, Naghmeh; Ghorbanzadeh, Abdollah; Sarraf, Pegah; Moayeri, Razieh Sadat

doi:10.4103/denthyp.denthyp_23_19

Cited by 5 publications

(7 citation statements)

References 2 publications

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“…The use of these fibrin-based products has significantly reduced pain and the duration of hospital stay by lowering the appearance of postoperative hematomas. 53 Fibrin sealants reduce the cost and time required for these operations.…”

Section: Fibrinogen Basics: Structure Polymerization Acquisition and ...mentioning

confidence: 99%

Technological advances in fibrin for tissue engineering

et al. 2023

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Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering.

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Section: Fibrinogen Basics: Structure Polymerization Acquisition and ...mentioning

confidence: 99%

Technological advances in fibrin for tissue engineering

et al. 2023

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“…It contains several factors that accelerate angiogenesis, chemotaxis, mitosis and cell proliferation [23,24]. The results of the related research indicated a beneficial antimicrobial effect of L-PRF and the release of growth factors and matrix proteins for over 7 days [24,25].…”

Section: Leucocyte Platelet-rich Fibrin (L-prf)mentioning

confidence: 99%

“…Computed tomography showed that the areas of lesions subsided or decreased and bone density increased in all teeth. Despite the rapid action of PRP, the authors drew attention to the disadvantages that are associated with this method, including the need for the taking of blood from the patient [25,52,53]. Because of this, they recommend the technique of induced bleeding as a standard procedure for the revascularization of non-vital immature permanent teeth, which gives delayed results but is less onerous [52,53].…”

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

“…Periodontitis is the breakdown of periodontal tissues, which occurs along with bone loss and clinical attachment, as well as apical migration of the junctional epithe-lium, which can induce the formation of vertical (angular) and/or horizontal bone defects [25,26]. It manifests in the inflammatory response of periodontal tissues to periodontal pathogens [28,57].…”

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

“…It manifests in the inflammatory response of periodontal tissues to periodontal pathogens [28,57]. Risk factors for this disease are poor oral hygiene, smoking, genetic predisposition and many systemic diseases, such as diabetes, cardiovascular disease and stroke [25,27].…”

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

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PRP and PRF—Subgroups and Divisions When Used in Dentistry

Pietruszka

Chruścicka

Duś-Ilnicka

et al. 2021

JPM

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Blood derivates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are autogenous sources of many growth factors that are involved in the healing and regeneration of tissues, and for this reason, are used in dentistry treatments. This fact also contributes to the growing interest in these biomaterials in regenerative personalized medicine. The multitude of platelet-rich forms creates many possibilities for their use. This semi-systematic review describes and compares the methods of obtaining properties and potential uses of these materials in personalized treatments.

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