Application of the near-infrared spectroscopy in the pharmaceutical technology

Jamrógiewicz, Marzena

doi:10.1016/j.jpba.2012.03.009

Cited by 224 publications

(83 citation statements)

References 83 publications

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“…It is widely used for quality control [1] and process monitoring in food [2,3], pharmaceuticals [4,5] and timber [6,7] industries. Other important DOS applications are in biomedical diagnostics [8][9][10][11] and medical treatment monitoring [12], respectively.…”

Section: Introductionmentioning

confidence: 99%

Computationally effective solution of the inverse problem in time-of-flight spectroscopy

Kamran¹,

Abildgaard²,

Subash³

et al. 2015

Opt. Express

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Photon time-of-flight (PTOF) spectroscopy enables the estimation of absorption and reduced scattering coefficients of turbid media by measuring the propagation time of short light pulses through turbid medium. The present investigation provides a comparison of the assessed absorption and reduced scattering coefficients from PTOF measurements of intralipid 20% and India ink-based optical phantoms covering a wide range of optical properties relevant for biological tissues and dairy products. Three different models are used to obtain the optical properties by fitting to measured temporal profiles: the Liemert-Kienle model (LKM), the diffusion model (DM) and a white Monte-Carlo (WMC) simulation-based algorithm. For the infinite space geometry, a very good agreement is found between the LKM and WMC, while the results obtained by the DM differ, indicating that the LKM can provide accurate estimation of the optical parameters beyond the limits of the diffusion approximation in a computational effective and accurate manner. This result increases the potential range of applications for PTOF spectroscopy within industrial and biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Computationally effective solution of the inverse problem in time-of-flight spectroscopy

Kamran¹,

Abildgaard²,

Subash³

et al. 2015

Opt. Express

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“…They are non-destructive and extremely useful for providing structural information about molecules in terms of their functional groups, the orientation of those groups and information on isomers. In association with chemometric methods they can also be used to provide quantitative information [14][15][16]. IR and Raman spectroscopies are similar insofar as they both produce spectra based on vibrational transitions within a molecule and use the same spectral regions [6].…”

Section: Infrared and Raman Spectroscopymentioning

confidence: 99%

“…A screening of the literature data has shown that among others, thermoanalytical and spectroscopic techniques can be used to a large extent in the drug and food analysis. Numerous papers published recently revealed some examples of usefulness of differential scanning calorimetry (DSC) [7][8][9][10][11], thermogravimetry (TG) [7,8,12,13], Fourier-transform infrared (FTIR) [10,[13][14][15], near infrared (NIR) [11,14,16] and Raman [9,14,[17][18][19][20] techniques for analytical purposes.…”

Section: Introductionmentioning

confidence: 99%

Detection of magnesium compounds in dietary supplements and medicinal products by DSC, Infrared and Raman techniques

Wesołowski

Leyk

Szynkaruk

2014

J Therm Anal Calorim

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The aim of this study was to learn to what extent the selected instrumental techniques, differential scanning calorimetry (DSC), as well as Fourier-transform infrared (FTIR) and Raman spectroscopies, can be used to detect both organic or inorganic magnesium compounds in the dietary supplements and medicinal products. Besides magnesium compounds as the active pharmaceutical ingredients (APIs), the preparations contain also other organic and inorganic APIs and several excipients. The study will be extended over the analysis of the products manufactured by various firms but containing the same API at different levels. In this way, it will be possible to assess the impact of excipients on the DSC scans and the FTIR and Raman spectra of a dominant constituent present in a studied preparation. The study on thirty commercially available dietary supplements and medicinal products has shown that in the majority of cases the DSC, FTIR and Raman techniques could be used for the detection of APIs in these commercial products. This was possible with the aid of the endothermic DSC peaks and the so-called matching factors of the FTIR and Raman spectra to those of substances used as standards. Both the complex composition and low levels of API in the studied preparations have been identified as the factors which have a strong impact on the usefulness of the three techniques for the detection of APIs in the dietary and medicinal products.

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“…Compared to traditional analytical methods, near-infrared spectroscopy (NIRS) has been proved to be a more versatile and fastgrowing analytical tool not only in the pharmaceutical sciences but also in the industry. The main advantages of this technique are that it is noninvasive and nondestructive, has no sample preparation required, large number of molecules which could be quantified, and is very fast due to the high frequency of spectrum acquisition [2].…”

Section: Introductionmentioning

confidence: 99%

“…For example, powder mixing is an essential unit operation for manufacturing fixed-dose combination, because inadequate mixing process conducts to poor quality of the final product due to low blend uniformity that is critical to ensure compliant content uniformity per united dose [9]. An important goal for NIRS analysis in pharmaceutical industry is a direct evaluation of powder blends during the mixing process as on-line, in-line, or at-line testing [2,10].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Alecu

Tomuță

2017

Journal of Spectroscopy

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Near-infrared spectroscopy (NIRS) is a technique widely used for rapid and nondestructive analysis of solid samples. A method for simultaneous analysis of the two components of paracetamol and caffeine from powder blends has been developed by using chemometry with near-infrared spectroscopy (NIRS). The method development was performed on samples containing 80, 90, 100, 110, and 120% active pharmaceutical ingredients, and near-infrared spectroscopy (NIRS) spectra of prepared powder blends were recorded and analyzed in order to develop models for the prediction of drug content. Many calibration models were applied in order to perform quantitative determination of drug content in powder, and choosing the appropriate number of factors (principal components) proved to be of highly importance for a PLS chemometric calibration. Once the methods were developed, they were validated in terms of trueness, precision, and accuracy. The results obtained by NIRS methods were compared with those obtained by HPLC reference method, and no significant differences were found. Therefore, the NIR chemometry methods were proved to be a suitable tool for predicting chemical properties of powder blends and for simultaneous determination of active pharmaceutical ingredients.

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Application of the near-infrared spectroscopy in the pharmaceutical technology

Cited by 224 publications

References 83 publications

Computationally effective solution of the inverse problem in time-of-flight spectroscopy

Computationally effective solution of the inverse problem in time-of-flight spectroscopy

Detection of magnesium compounds in dietary supplements and medicinal products by DSC, Infrared and Raman techniques

Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

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