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The aim of this study was to learn to what extent the selected instrumental techniques, differential scanning calorimetry (DSC), as well as Fourier-transform infrared (FTIR) and Raman spectroscopies, can be used to detect both organic or inorganic magnesium compounds in the dietary supplements and medicinal products. Besides magnesium compounds as the active pharmaceutical ingredients (APIs), the preparations contain also other organic and inorganic APIs and several excipients. The study will be extended over the analysis of the products manufactured by various firms but containing the same API at different levels. In this way, it will be possible to assess the impact of excipients on the DSC scans and the FTIR and Raman spectra of a dominant constituent present in a studied preparation. The study on thirty commercially available dietary supplements and medicinal products has shown that in the majority of cases the DSC, FTIR and Raman techniques could be used for the detection of APIs in these commercial products. This was possible with the aid of the endothermic DSC peaks and the so-called matching factors of the FTIR and Raman spectra to those of substances used as standards. Both the complex composition and low levels of API in the studied preparations have been identified as the factors which have a strong impact on the usefulness of the three techniques for the detection of APIs in the dietary and medicinal products.

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Tom 75 • nr 11 • 2019 jakim podlegają substancje stosowane do celów farmaceutycznych, tj. aktywne składniki farmaceutyczne (ang. active pharmaceutical ingredients, APIs), substancje pomocnicze, półprodukty i gotowe produkty farmaceutyczne [1-7]. Najważniejsze procesy, jakie z punktu widzenia farmacji mogą być badane tymi technikami, to przemiany fazowe-przemiana szklista, topnienie, krystalizacja, parowanie, sublimacja, dehydratacja i hydratacja, solwatacja i desolwatacja, polimorfizm i pseudopolimorfizm, a ponadto, reakcje M etody analizy termicznej, w szczególności różnicowa analiza termiczna (ang. Differential thermal analysis, DTA), różnicowa kalorymetria skaningowa (ang. differential scanning calorimetry, DSC) i analiza termograwimetryczna (ang. thermogravimetric analysis, TGA), są nowoczesnymi, skomputeryzowanymi i zautomatyzowanymi technikami analizy instrumentalnej, które umożliwiają badanie w różnych warunkach tem