Application of Sub-Critical Water Extraction in Pharmaceutical Industry

Liang, Xiaoxia; Fan, Qiao-Jia

doi:10.4236/msce.2013.15001

Cited by 44 publications

(39 citation statements)

References 34 publications

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“…27 It has been stated that controlling both temperature and pressure within a sealed system manipulates the chemical and physical properties of water. 28 As the temperature increases both hydrogen bonding and dipole-dipole interactions of water becomes weak. As a result the weak hydrogen bonds and dipole-dipole interactions are able to disrupt the strong-solute matrix of an organic compound.…”

mentioning

confidence: 99%

Development and characterization of a xenograft material from New Zealand sourced bovine cancellous bone

Ratnayake

Gould

Shavandi

et al. 2016

J. Biomed. Mater. Res.

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A xenograft (bovine hydroxyapatite [BHA]) was developed from New Zealand sourced bovine cancellous bone by a successful defatting and deproteinizing procedure. The BHA was chemically, compositionally and structurally characterized. Fourier transform infrared spectroscopy confirmed the removal of organic matter from the bone matrix and the presence of carbonate ( CO32-), hydroxyl (OH ), and phosphate ( PO43-) functional groups. X-ray diffraction analysis suggested that the processed bone corresponds characteristically to hydroxyapatite (HA). SEM analysis showed that the BHA has an interconnected porous architecture with a pore diameter ranging from 100 to 700 μm while µCT analysis calculated the total porosity as 73.46% ± 1.08. Furthermore, the BHA was stable up to 1000°C and lost only 1.8% of its weight. The Ca/P molar ratio of the BHA was 1.58, which is comparable with commercially available natural HA-Endobon . After 28 days of incubation in simulated body fluid (SBF), the pH value only fluctuated between 7.1 and 7.5 and the BHA scaffold did not degrade significantly by weight indicating the scaffold had excellent chemical and structural stability. In vitro studies showed the BHA was cytocompatible and supported the proliferative growth of Saos-2 osteoblast cells. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1054-1062, 2017.

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mentioning

confidence: 99%

Development and characterization of a xenograft material from New Zealand sourced bovine cancellous bone

Ratnayake

Gould

Shavandi

et al. 2016

J. Biomed. Mater. Res.

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“…The most effective and innovative method of extracting plant raw materials in the food and pharmaceutical industries is currently the extraction by subcritical water (SCW) [5][6][7]. SCW -water in a liquid state at a pressure of up to 21,8 in the temperature range between the usual boiling point (100 °C) and the critical temperature (374 °C).…”

Section: Food Science and Technologymentioning

confidence: 99%

Establishing the Equipment-Methodical Support for Determining the Properties of Extracts of Grape Pomace Extracts Produced in the Subcreative Water Environment

Sukmanov

Ukrainets

Zavialov

et al. 2017

EUREKA: Life Sciences

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Research objective: development of a high-pressure reactor for researching the process of extraction of grape pomace by the subcritical water and determining the parameters, providing the maximum yield of various target products – biologically active substances; formation of methodological support for raw material preparation, qualitative and quantitative analysis of extracts, produced by the subcritical extraction. As a result of simulation in the ANSYS system of the stress-strain state of the walls of the reactor chamber and a set of calculation operations, a high-pressure reactor was created that meets the requirements. The formed methodical complex for determining the physicochemical properties of extracts and the content of various biologically active substances included methods for preparing samples and determining the yield of dry extractive substances, evaluation of extraction of polyphenols (tannic-catechol complex), evaluation of extraction of reducing substances, identification furfural and gallic acids, estimation of free organic acids in terms of tartaric acid, evaluation of antioxidant activity of extracts). This methodological complex allows us to estimate the physico-chemical properties of the extracted biologically active substances.

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“…The most effective method of extracting plant raw materials in the food and pharmaceutical industries is currently the SCW extraction [12][13][14]. The terms used for the description of SCW: "subcritical water", "high-temperature water", "superheated water", "pressurized hot water", "pressurized low polarity hot water".…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the SCW extraction of BAS from various plant and algae species in the food, cosmetic and pharmaceutical industries is considered as the most innovative technology [13,14].…”

Section: Introductionmentioning

confidence: 99%

Research of extraction of biologically active substances from grape pomace by the subcritical water

Sukmanov

Ukrainets

Zavialov

et al. 2017

EEJET

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Application of Sub-Critical Water Extraction in Pharmaceutical Industry

Cited by 44 publications

References 34 publications

Development and characterization of a xenograft material from New Zealand sourced bovine cancellous bone

Development and characterization of a xenograft material from New Zealand sourced bovine cancellous bone

Establishing the Equipment-Methodical Support for Determining the Properties of Extracts of Grape Pomace Extracts Produced in the Subcreative Water Environment

Research of extraction of biologically active substances from grape pomace by the subcritical water

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