Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine

Киселев, М. А.; Zemlyanaya, E. V.; Ipatova, O. M.; Gruzinov, Andrey; Ermakova, E. V.; Zabelin, A. V.; Zhabitskaya, Evgeniya; Druzhilovskaya, O.S.; Аксенов, В. Л.

doi:10.1016/j.jpba.2015.05.034

Cited by 12 publications

(10 citation statements)

References 11 publications

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“…The procedure of SAXS measurement and the sample preparation is the same as in [9]. The measurements were carried out at two sample-to-detector distances of L sd = 30 and 243.5 cm with a photon wavelength of λ = 1.62Å.…”

Section: Methodsmentioning

confidence: 99%

“…From the point of practical applications, the information on the structure and properties of PTNS nanoparticles in different media is needed. In the recent work [9], on the basis of SAXS data collected at the Kurchatov Synchrotron Radiation Source of the National Research Center "Kurchatov Institute" (Moscow, Russia), the conclusion about vesicular structure of PTNS nanoparticles has been made and an estimation of average size of PTNS particles has been obtained.…”

Section: Introductionmentioning

confidence: 99%

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SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2016

J. Phys.: Conf. Ser.

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Abstract. Experimental data on the small angle synchrotron X-ray scattering (SAXS) are analyzed on a basis of Separated form factors method (SFF) for a study of the drug delivery Phospholipid Transport Nano System (PTNS). Basic parameters of polydispersed population of PTNS nanoparticles (average radius of PTNS-particles, polydispersity of radius, thickness of membrane) have been determined. The results are discussed in comparison with the SFF results for the "classical" vesicular system of dimyristoylphosphocholine (DMPC).

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2016

J. Phys.: Conf. Ser.

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“…Incorporation of drugs into PTNS ULVs is found to increase sufficiently the therapeutic effectiveness. The structure of PTNS ULVs was analysed in [12,13] on the basis of SAXS data collected at the Kurchatov Synchrotron Radiation Source of the NRC "Kurchatov Institute" (Moscow, Russia). Here, we present first estimations of basic parameters of PTNS ULVs in the heavy water solvent of maltose on the basis of the HH-SFF analysis of SANS data collected at YuMO spectrometer.…”

Section: Analysis Of Ptns Ulvs Structurementioning

confidence: 99%

Determination of the Vesicular Systems Parameters: Parallel Implementation and Analysis of the PTNS Vesicle Structure

et al. 2018

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Abstract. Parameters of the phospholipid vesicular systems are determined by means of minimization of the discrepancy between experimental data on the small angle scattering intensity and the numerical results within the frame of the separated form factors method. Effectiveness of parallel implementation is tested at the cluster HybriLIT. Results of numerical analysis of small angle neutron scattering data on polydispersed population of unilamellar vesicles of phospholipid transport nanosystem are presented.

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“…Due extremely small size of PTNS nanoparticles, the medical drugs incorporation into PTNS ULVs sufficiently improves their therapeutic effectiveness [16,17]. Estimations of basic parameters of PTNS ULVs within the frame of different approaches are presented in [18,19,20]. In our recent work [21], the structure of PTNS polydispersed population of ULVs in water solvent of maltose (concentration 20%, 25%, and 30%) has been analysed on the basis of the SAXS experimental data collected at the Kurchatov Synchrotron Radiation Source of the National Research Center "Kurchatov Institute" (Moscow, Russia).…”

Section: Introductionmentioning

confidence: 99%

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2018

J. Phys.: Conf. Ser.

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Abstract. The small-angle neutron scattering technique (SANS) is employed for investigation of structure of the phospholipid transport nanosystem (PTNS) elaborated in the V.N.Orekhovich Institute of Biomedical Chemistry (Moscow, Russia). The SANS spectra have been measured at the YuMO small-angle spectrometer of IBR-2 reactor (Joint Institute of Nuclear Research, Dubna, Russia). Basic characteristics of polydispersed population of PTNS unilamellar vesicles (average radius of vesicles, polydispersity, thickness of membrane, etc.) have been determined in three cases of the PTNS concentrations in D2O: 5%, 10%, and 25%. Numerical analysis is based on the separated form factors method (SFF). The results are discussed in comparison with the results of analysis of the small-angle X-ray scattering spectra collected at the Kurchatov Synchrotron Radiation

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Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine

Cited by 12 publications

References 11 publications

SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

Determination of the Vesicular Systems Parameters: Parallel Implementation and Analysis of the PTNS Vesicle Structure

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

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