Four factorial trials were conducted with yam (Dioscorea rotundata Poir.) at Ibadan, Nigeria from 2013 to 2015, investigating effects of (1) tillage ( 2) fertilizer ( 3) intercropping ( 4) yam plant densities. Yam tuber yields varied between years (2013: 16.44 Mg ha −1 ; 2014: 10.08 Mg ha −1 ; 2015 26.61 Mg ha −1 ). In 2013 neither tillage nor fertilizer affected tuber yields. In 2014 tillage increased yields (+25.4%, P < 0.0001), fertilizer reduced yield (−10.5%; P = 0.0046). In 2015 tillage increased tuber yields by 8.1% (ns), fertilizer application increased yield (+17.5%, P = 0.0017). Across the years, tuber yields increased (P < 0.01) with increasing yam density with a constant increase in 2013 up to the highest density, yet yields leveled out above 14,815 plants ha −1 in 2014 and 2015. Intercropping with maize (66,667 plants ha −1 ) reduced tuber yield by 42.62% in 2013, 44.52% in 2014 and 30.68% in 2015 (P < 0.01 all years) across all yam densities. Maize grain yield was higher in sole crop in 2 years. Fertilizer increased yields in all years (P < 0.0001). Maize yield had no response to the yam densities. Ridging had a negative effect on grain yield in 2015 (−0.3 Mg ha −1 , P = 0.0002).Increasing plant density appears a safe measure to increase yam yields.