Application of natural deep eutectic solvents for extraction and determination of phenolics in Cajanus cajan leaves by ultra performance liquid chromatography

Wei, Zuo‐Fu; Qi, Xiao‐Lin; Li, Tingting; Luo, Meng; Wang, Wei; Zu, Yuangang; Fu, Yujie

doi:10.1016/j.seppur.2015.05.015

Cited by 236 publications

(121 citation statements)

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“…Regarding R L/S , the optimum level of 45 mL g −1 found was higher than those used in other cases of polyphenol extraction with various LTTMs, which ranged between 10 and 20 mL g −1 [17][18][19]. Yet, R L/S of 36.2 mL g −1 has also been reported [15].…”

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confidence: 84%

“…Likewise, in the limited number of available studies dealing with polyphenol extraction with LTTMs, the effect of T, which plays central role in an extraction process, appears to be stronger at relatively moderate levels, varying from 60 to 80 • C [17][18][19], whereas higher T have not been tested. The optimal value determined in this study was 73 • C, which fell within such a range.…”

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confidence: 99%

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Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

et al. 2017

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Abstract:Olive leaves (OLL) represent a major waste generated during the production of olive oil, but there is a great potential for their valorization, because they provide important content in polyphenolic phytochemicals, which possess several bioactivities. In spite of the high number of studies dealing with polyphenol recovery from olive leaves, green processes involving environmentally benign solvents are scarce. In this study, a novel renewable natural low-transition temperature mixture (LTTM), composed of glycerol and sodium-potassium tartrate, was tested for its efficient ability to extract polyphenolic substances from OLL. The extraction process was optimised by using response surface methodology and the maximum yield in total polyphenols was 26.75 ± 3.22 mg caffeic acid equivalents per g dry weight, achieved with 50% (v/v) aqueous LTTM, liquid-to-solid ratio of 45 mL g −1 and at 73 • C. The LTTM was proven to be equally effective with 60% aqueous methanol, but it displayed inferior antioxidant properties. Liquid chromatography-diode array-mass spectrometry analyses revealed no significant qualitative differences between the LTTM and the aqueous methanolic extract.

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confidence: 84%

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confidence: 99%

Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

et al. 2017

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“…NADES therefore have good potential for the extraction of valuable secondary metabolites for use in the food and pharmaceutical industries. Recently, NADES have been applied for extraction of flavonoids (Wei et al 2015a;Radošević et al 2016;Bakirtzi et al 2016;Dai et al 2016), alkaloids, phenolic acids, anthraquinones, saponins (Duan et al 2016, phenolic compounds (Wei et al 2015b), xanthonoids (Mulia et al 2015), rutin (Huang et al 2017), flavonoid glycosides, and aglycones (Zhuang et al 2017) from plant materials. The mentioned publications describe the extraction of flavonoids other than those described in our research and the application of different NADES solvents for sample preparation.…”

Section: Introductionmentioning

confidence: 99%

Development of a Method Based on Natural Deep Eutectic Solvents for Extraction of Flavonoids from Food Samples

2017

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Natural deep eutectic solvents (NADES) are promising green solvents for the extraction of compounds from natural products. This is the first study to use a sample preparation method based on NADES for the extraction of flavonoids (rutin, hesperidin, neohesperidin, naringenin, naringin, quercetin, hesperetin, and chrysin) from fruits, vegetables, and spices. In total, 17 types of NADES based on choline chloride, acetylcholine chloride, choline tartrate, betaine, and carnitine with different compositions were tailored to test their extraction efficiency. Operational conditions such as water content in NADES and liquid/solid ratios were also studied. A response surface methodology was used for multivariate optimization of some extraction parameters. Efficient recovery of extracted flavonoids (higher than 70%) was achieved using a 30% water solution of acetylcholine chloride/lactic acid ratio (2:1) as an extraction solvent. Other conditions for SLE-NADES were as follows: liquid/solid ratio 3:1, extraction temperature 60°C, extraction time 30 min, and stirring speed 1400 rpm. Each extract was analyzed by UHPLC with UVand MS/ MS detection. The developed method was applied for analysis of flavonoids in fruits (cranberry, fruits of Lycium barbarum L., grape, plum, and orange peel), vegetables (onion and broccoli), and spices (mustard, rosemary, and black pepper).

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“…Flavonoids are successful compounds being extracted and separated by using DESs from medicinal plants, and DES extraction provides more efficient extraction than other solvents [6,7].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Total Phenolic Content of Catharanthus roseus Using Deep Eutectic Solvent

Nisar¹,

Mamat²,

Hatim³

et al. 2017

Recent Advances in Biology and Medicine

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Deep eutectic solvents as a new type of eco-friendly solvents have attracted attention in chemistry, medicine, and other fields for the extraction and separation of target compounds from medicinal plants. Deep eutectic solvents are easy to prepare and have many advantages as solvents, such as chemical inertness with water, low cost, easy biodegradability, and pharmaceutically acceptable toxicity. In this study, a deep eutectic solvent made up of choline chloride-glycerol (1:2) was used for the extraction of flavonoids from Catharanthus roseus plant parts (flower petal, leaves, stem, and root). The highest amount of phenolic content was detected in flower petal, that is, 194.50 mg GAE/g. In DPPH test, the maximum amount of antioxidant activity determined in the flower petal was 73.13%; IC 50 was calculated by using a linear regression equation; IC 50 value of the standard, stem, root, leaf, and flower petal was 13.22, 90.44, 83.93, 120.14, 79.49 μg/ml, respectively. The result of this research is that Catharanthus roseus has a compatible antioxidant activity. This can be helpful for the treatment of diseases caused by free-radical oxidative stress.

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Application of natural deep eutectic solvents for extraction and determination of phenolics in Cajanus cajan leaves by ultra performance liquid chromatography

Cited by 236 publications

References 31 publications

Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

Development of a Method Based on Natural Deep Eutectic Solvents for Extraction of Flavonoids from Food Samples

Antioxidant and Total Phenolic Content of Catharanthus roseus Using Deep Eutectic Solvent

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