Application of Nanoantibiotics Approach Against Anti-Bacterial Resistance

Abstract

Despite the fact that we live in an era with unique and advanced technology for revealing underlying molecularly creating new drugs and disease mechanisms, infectious illnesses remain one of the world's major health issues. Antimicrobial agents now available against pathogenic microorganisms are insufficient to combat the problems posed by novel multidrug-resistant (MDR) infections. Antimicrobial drug restrictions are producing negative side effects and the development of multiple drug resistance. Drug resistance will necessitate the use of high-dose antibiotics, resulting in severe toxicity and the development of new medicines. Nanoantibiotics, a new type of antimicrobial agent that combines antimicrobial compounds with nanoparticles, has been created to solve these shortcomings. Additionally, previous reports stated that the pharmacokinetics profiles and have quicker ingestion in circulatory framework. In this subject, we will clarify the various sorts of nanoantibiotics, their instrument of activity, key targets and medication discharge components. We will likewise portray some significant microbial elements that will influence the activity of nanoantibiotics.

Antibacterial Activity of Liquid Crystal Nanoparticles Gel of Binjai Leaves Methanol Extract (Mangifera Caesia Jack. Ex. Wall.) Against Propionibacterium Acnes

“…The results gave promises that the LCNPs as a delivery system can increase drug penetration to the skin especially Binjai leaves as a traditional drug from South Kalimantan that has potential as antiacne for cosmetic ingredients [31]. P. acnes has been recognized as a prime target for the medical treatment of acne because this bacterium promotes acne inflammation by inducing increased production of pro-inflammatory cytokines, resulting in the accumulation of neutrophils and oxygenfree radicals produced by neutrophils in acne lesions.…”