Application of modified pyrolytic graphite electrode as a sensor in the simultaneous assay of adenine and adenosine monophosphate

Goyal, Rajendra N.; Chatterjee, Sanghamitra; Rana, Anoop Raj Singh; Chasta, Himanshu

doi:10.1016/j.snb.2011.04.017

Cited by 21 publications

(7 citation statements)

References 32 publications

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“…These two complementary bases are found in cells, physiological fluids and tissues. They play a vital role in various life processes [37] such as dietary habits, catabolism of nucleic acids, enzymatic degradation of tissue and various salvage pathways [38][39][40]. That is why the quantitative measurement of adenine and thymine or adenine-thymine (AT) base pair assumes profound importance for the investigation of many health related issues and also for performing genetic diagnosis [38].…”

Section: Sa Siddiqui / Gan Doped C 60 As a Nano Bio Sensor For The mentioning

confidence: 99%

GaN doped C60 as a nano bio sensor for the detection of mispairing in adenine-thymine base pair

Siddiqui

2014

Main Group Chemistry

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It is always difficult to differentiate between normal and rare tautomeric form of various nucleic acid bases as they have similar electronic structure and energies. In the present work we performed theoretical calculations in order to accomplish the task of differentiating between adenine-thymine base pair and rare tautomer of adenine-thymine base pair using GaN doped fullerene (C 58 GaN). We used Density Functional Theory with the popular B3LYP functional in all calculations. The HOMO-LUMO gap was used to examine the electronic properties of these complexes. Our findings reveal that GaN doped C 60 can be used as a nano-biosensor.

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Section: Sa Siddiqui / Gan Doped C 60 As a Nano Bio Sensor For The mentioning

confidence: 99%

GaN doped C60 as a nano bio sensor for the detection of mispairing in adenine-thymine base pair

Siddiqui

2014

Main Group Chemistry

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“…Thus, in the current investigation a nano hybrid material of single walled carbon nanotubes (SWNTs) and Fe 3 O 4 nanoparticles along with nafion have been exploited for the first time for SSZ determination. SWNT is one of the most propitious candidates for the modification of sensors due to its potential features such as high electrical conductivity, remarkable electron transport capacity, significantly large surface area and excellent mechanical strength [26–30] . Fe 3 O 4 on the other hand, manifests strong adsorption ability, high abundance, low mass transfer resistance, biocompatibility, low toxicity and phenomenal magnetic and electrochemical properties [31–34] .…”

Section: Introductionmentioning

confidence: 99%

Trace Level Recognition of Sulfasalazine Electrooxidation Exploiting the Synergism of Carbon Nanotubes and Iron Oxide Nanoparticles

Mane

Chatterjee

2021

ChemistrySelect

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The significance of sulfasalazine (SSZ) as a therapeutic agent has garnered paramount research interest in the design and fabrication of a viable sensor for the detection of SSZ. Herein, we demonstrate a new strategy for the sensitive determination of SSZ employing single walled carbon nanotubes decorated with Fe3O4 nanoparticles sensing platform for the first time. The synthesized Fe3O4 nanoparticles and the surface morphology of the developed sensor were investigated by exerting various analytical techniques. The optimization of operational parameters was effectuated. The developed sensor exhibited pronounced electrocatalytic activity for the electro oxidation of SSZ in the dynamic detection range of 25 nM–1.5 μM manifesting noteworthy high sensitivity and phenomenal low detection limit of 18.6 μA μM−1 and 1.6 nM respectively. Apparent specificity in the presence of interferents along with remarkable stability and reproducibility were attained by the sensor. The prominence of the developed methodology was emphasized by the determination of SSZ in pharmaceutical formulations. Furthermore, the applicability of the developed electrode was established by utilizing it effectually for the first time to quantify SSZ in serum sample of patients undergoing pharmacological treatment for rheumatoid arthritis.

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“…The applications of advanced electrochemical techniques have allured considerable attention in modern analytical chemistry for the detection of biologically significant analytes . Electrochemical measurements are based on two important factors, in which the potential being related to qualitative properties and the current related to quantitative properties of the compound.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Comparison of Single‐Walled and Multi‐Walled Carbon Nanotubes Utilizing Paeonol as the Model Drug

Mane

Chatterjee

2018

ChemistrySelect

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Herein, we report the development of a selective and highly sensitive electrochemical sensing of paeonol at carbon nanotubes modified glassy carbon electrode (GCE). Trace amount of paeonol was quantitated by employing square wave voltammetry technique for the first time based on the electrochemical oxidation of the analyte at the modified electrodes. The single walled carbon nanotubes (SWNTs) based sensor exhibited higher recognition ability of paeonol in comparison with the multi walled carbon nanotubes (MWNTs) based sensor. The linear dynamic range was found to be 100 nM – 25 μM for SWNTs modified GCE and 1–25 μM for MWNTs modified GCE. The sensitivity at SWNTs modified GCE was ∼ 3.5 times more than that at MWNTs modified GCE. The limit of detection was estimated to be 9.57 nM and 0.63 μM corresponding to SWNTs and MWNTs modified GCE respectively. The influence of experimental parameters affecting sensor response was optimized. The stability, reproducibility tests and interference effects were demonstrated to confirm the reliability of the proposed sensor. The applicability of the developed sensor was successfully assessed through convenient measurements of paeonol in biological samples and Cortex moutan which exhibits anticancer effect.

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Application of modified pyrolytic graphite electrode as a sensor in the simultaneous assay of adenine and adenosine monophosphate

Cited by 21 publications

References 32 publications

GaN doped C60 as a nano bio sensor for the detection of mispairing in adenine-thymine base pair

GaN doped C60 as a nano bio sensor for the detection of mispairing in adenine-thymine base pair

Trace Level Recognition of Sulfasalazine Electrooxidation Exploiting the Synergism of Carbon Nanotubes and Iron Oxide Nanoparticles

An Electrochemical Comparison of Single‐Walled and Multi‐Walled Carbon Nanotubes Utilizing Paeonol as the Model Drug

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