Trace Level Recognition of Sulfasalazine Electrooxidation Exploiting the Synergism of Carbon Nanotubes and Iron Oxide Nanoparticles

Abstract

The significance of sulfasalazine (SSZ) as a therapeutic agent has garnered paramount research interest in the design and fabrication of a viable sensor for the detection of SSZ. Herein, we demonstrate a new strategy for the sensitive determination of SSZ employing single walled carbon nanotubes decorated with Fe3O4 nanoparticles sensing platform for the first time. The synthesized Fe3O4 nanoparticles and the surface morphology of the developed sensor were investigated by exerting various analytical techniques. The optimization of operational parameters was effectuated. The developed sensor exhibited pronounced electrocatalytic activity for the electro oxidation of SSZ in the dynamic detection range of 25 nM–1.5 μM manifesting noteworthy high sensitivity and phenomenal low detection limit of 18.6 μA μM−1 and 1.6 nM respectively. Apparent specificity in the presence of interferents along with remarkable stability and reproducibility were attained by the sensor. The prominence of the developed methodology was emphasized by the determination of SSZ in pharmaceutical formulations. Furthermore, the applicability of the developed electrode was established by utilizing it effectually for the first time to quantify SSZ in serum sample of patients undergoing pharmacological treatment for rheumatoid arthritis.

A 3,8-connected Cd(ii)-based metal–organic framework as an appropriate luminescent sensor for the antibiotic sulfasalazine

“…However, on introducing SLA to the mixture of 1 and other antibiotics, the emission intensity of 1 was significantly quenched, which is indicative of its high selectivity toward SLA. To the best of our knowledge, only seven complex-derived probes for SLA have been reported to date (Table 2), [37][38][39][40][41][42] which suggests that the sensing properties of 1 presented in this work are comparable to most of the reported fluorescent probes. 43,44 Further, the recyclability of 1 as a sensor for SLA was examined and the outcomes of the recycling experiments are shown in Fig.…”

Effect of Magnesium Chloride in Supporting Electrolyte for Enhancing Sensitive and Selective Electrochemical Sensor: An Approach for Anti-Rheumatic Sulfasalazine Detection

“…Electrochemical methods have been used for various applications, especially for clinical and pharmaceutical monitoring, because of the growing demand from medical and hospital laboratories for rapid analysis, inexpensive devices, and user-friendliness. 8,9 For the detection of SSZ, some electrochemical sensing approaches based on metallic nanoparticles, 10,11 carbonaceous materials 12 and conductive polymer 13 modified electrodes have been developed. However, those platforms require multi-step modifications, complicated operations, and costly chemicals, which prevent their widespread application.…”