Application of Hydroxyapatite-Sol as Drug Carrier

Kano, Seisuke; Yamazaki, Atsushi; Ôtsuka, Ryohei; Ohgaki, Masataka; Akao, Masaru; Aoki, Hideki

doi:10.3233/bme-1994-4404

Cited by 38 publications

(29 citation statements)

References 14 publications

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“…The average mineral content of bone tissue is species dependent and lies within the range of 50 to 74 wt % [ 1 ]. Hydroxyapatite (HAp) [Ca 10 (PO 4 ) 6 (OH) 2 ], is considered to play a vital role in various fields including the replacement of bone tissue [ 2 ], reconstruction of skull defects [ 3 ], tissue engineering [ 4 ], artificial bone synthesis [ 5 , 6 , 7 ], biosensor [ 8 ], removal of heavy metals [ 9 ], and as drug carrier [ 10 ]. HAp can be derived either from a natural source or by a synthetic method.…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature on Isolation and Characterization of Hydroxyapatite from Tuna (Thunnus obesus) Bone

2010

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The effect of temperature on isolation and characterization of hydroxyapatite (HAp) from tuna bone was evaluated at different temperatures ranging from 200 °C to 1200 °C. The calcined bones were characterized by thermo gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDX) and cytotoxicity assay. The FTIR and TGA results revealed the presence of inorganic and organic matrices in raw bone and a preserved carbonated group in the derived HAp. The XRD results of the derived HAp were coherent with the Joint Committee on Powder Diffraction Standards (JCPDS-09-0432/1996) data. In addition, FE-SEM results revealed the formation of nanostructured HAp (80–300 nm) at 600 °C and crystal agglomeration was observed with an increase in temperature. The calcium to phosphorous weight ratio was determined by EDX results of treated bones. Derived HAp with various crystal sizes had no cytotoxicity on the MG 63 cell line. Based on the analysis, we conclude that varying the isolation temperature between 600–900 °C has tremendous impact on the production of HAp from Thunnus obesus with required properties.

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Section: Introductionmentioning

confidence: 99%

Effect of Temperature on Isolation and Characterization of Hydroxyapatite from Tuna (Thunnus obesus) Bone

2010

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“…Apatite can also be used as a good ion exchange barrier and as an adsorbent that is tested for dye removal and protein separation [11][12][13][14][15][16][17]. Apatite is also studied as a carrier for sustained-release drugs or as a catalyst support [15,18,19]. The objective of this study is to synthesize the hydroxyapatites from natural phosphates and then apply the characterized material to as adsorbents of methylene blue in water.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Application of New Apatitic Materials Synthesized from Hahotoé-Kpogamé Phosphate Rock

Zounon¹,

Koriko²,

Kodom³

et al. 2019

CJAST

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Aims: Phosphorus and phosphate are broadly used in many areas ranging from advance researches to manufacturing companies for regular use purposes. In Togo, the raw phosphate is exploited and exported to serve as an ingredient in chemical fertilizers, detergents, phosphoric acid synthesis, etc. The aim of the present work is an investigation of alternative valuation of the raw phosphate of Hahotoé-Kpogamé in Togo. Methodology: The study consists of the transformation of the raw phosphate into hydroxyapatite by dissolution followed by a precipitation. The hydroxyapatite thus obtained can be used, for example as a conditioning matrix of industrial waste, as a catalyst support, or for the depollution of water etc. The characterization was carried out by Fourier Transform Infrared Spectroscopy, X-Ray Diffraction, Thermogravimetric Analysis coupled to Thermal Differential Analysis and Inductively Coupled Plasma Atomic Emission Spectroscopy. Results: These analyses revealed that the materials are predominantly of non-stoichiometric hydroxyapatite and minority of phosphate tricalcium and impurities. The synthesized materials (calcined and uncalcined) were applied as adsorbent and as coadsorbent of a photocatalyst (TiO2) for methylene blue removal. The study of the adsorption of the methylene blue was carried out in a batch mode. The adsorption of methylene blue on the synthesized materials gave a low yield (15 to 20%). However, used as in the mixture with titanium dioxide, the adsorption rate of methylen blue was increased significantly (57% of removal rate with 0.5 g synthesized materials + 2 g of TiO2 P25). Conclusion: uncalcined hydroxyapatite obtained from raw phosphate can be used as an efficient co-adsorbent of titanium dioxide leading to an alternative valorization of this natural phosphate.

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“…It has excellent biocompatibility and can absorb various substances by electrostatic attraction [18][19][20]. It is also an excellent material for ion exchange, and HAp derivatives with different physical properties can be manufactured by the substitution of various elements [21]. Nakane et al used the fact that the hydroxide groups of HAp can be easily exchanged for fluoride to improve the acid tolerance of HAp, and developed a fluorinated HAp-covered TiO2 [22].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Titanium Oxide Photocatalyst Supported on Spherical Porous Hydroxyapatite

Yoshijima

Tamazawa

Kodaira

et al. 2017

Trans. Mat. Res. Soc. Japan

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We report the synthesis of a photocatalytic composite of spherical porous hydroxyapatite (sHAp) and TiO2. sHAp was prepared by a wet method using simulated body fluid as a slurry and was then mixed with a TiO2 sol to obtain the sHAp + TiO2 composite. The TiO2 content of sHAp + TiO2 was ~7.8 wt. %. sHAp+TiO2 showed photocatalytic activity that was more than ten times greater than that of TiO2 even under irradiation with the low-intensity ultraviolet (UV) light of a fluorescent lamp. Mb decomposition of 58.2% was achieved under UV light with an intensity of 7.60 ×10 2 μW cm-2 using the sHAp + TiO2 composite, which is significantly higher than the 8.05% achieved using only TiO 2. Thus, the composite material showed higher activity than that of unsupported TiO2. Furthermore, sHAp + TiO2 could oxidize leucocrystal violet (LCV) to crystal violet (CV) even after being placed in the dark for 120 h. The positively charged holes are suggested to persist on TiO 2 because of the electron withdrawing effects of sHAp and can contribute to LCV oxidation. Thus, the photocatalytic activity of TiO2 was improved by using sHAp as a support.

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Application of Hydroxyapatite-Sol as Drug Carrier

Cited by 38 publications

References 14 publications

Effect of Temperature on Isolation and Characterization of Hydroxyapatite from Tuna (Thunnus obesus) Bone

Effect of Temperature on Isolation and Characterization of Hydroxyapatite from Tuna (Thunnus obesus) Bone

Characterization and Application of New Apatitic Materials Synthesized from Hahotoé-Kpogamé Phosphate Rock

Synthesis of Titanium Oxide Photocatalyst Supported on Spherical Porous Hydroxyapatite

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