In this study, a novel titania-supported spherical porous hydroxyapatite (sHAp + TiO2) was prepared by compounding minute, uniquely shaped spherical porous hydroxyapatites (sHAp) with TiO2. Adsorption of the representative protein bovine serum albumin (BSA) was evaluated and simulated body fluid immersion experiments were carried out. Minimal adsorption of BSA to TiO2 was observed, and 33% and 25% adsorption to sHAp + TiO2 and sHAp were observed, respectively. The reduction in BSA concentration observed in the sHAp and sHAp + TiO2 solutions is presumably due to adsorption to HAp. It is highly likely that adsorption of the acidic protein BSA occurred at the sHAp Ca2+ site. In the simulated body fluid immersion experiments, there was greater expression of hydroxyapatite (HAp) on the surface of sHAp than there was on the surface of sHAp + TiO2. In the case of TiO2 alone, no HAp was produced, even after immersion for 3 days. These results suggest a relationship between BSA adsorption and the osteoconductivity of materials.
We report the synthesis of a photocatalytic composite of spherical porous hydroxyapatite (sHAp) and TiO2. sHAp was prepared by a wet method using simulated body fluid as a slurry and was then mixed with a TiO2 sol to obtain the sHAp + TiO2 composite. The TiO2 content of sHAp + TiO2 was ~7.8 wt. %. sHAp+TiO2 showed photocatalytic activity that was more than ten times greater than that of TiO2 even under irradiation with the low-intensity ultraviolet (UV) light of a fluorescent lamp. Mb decomposition of 58.2% was achieved under UV light with an intensity of 7.60 ×10 2 μW cm-2 using the sHAp + TiO2 composite, which is significantly higher than the 8.05% achieved using only TiO 2. Thus, the composite material showed higher activity than that of unsupported TiO2. Furthermore, sHAp + TiO2 could oxidize leucocrystal violet (LCV) to crystal violet (CV) even after being placed in the dark for 120 h. The positively charged holes are suggested to persist on TiO 2 because of the electron withdrawing effects of sHAp and can contribute to LCV oxidation. Thus, the photocatalytic activity of TiO2 was improved by using sHAp as a support.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.