Application of Haar and Mexican hat wavelets to double divisor-ratio spectra for the multicomponent determination of ascorbic acid, acetylsalicylic acid and paracetamol in effervescent tablets

Abstract

A determinação simultânea de ácido ascórbico (AA), ácido acetilsalicílico (ASP) e paracetamol (PAR) em misturas sintéticas e tabletes efervescentes foi realizada usando-se as técnicas de transformações de Haar e transformações de onda pequena tipo chapéu mexicano (HAAR-CWT e MEXH-CWT, respectivamente), juntamente com a técnica de divisor duplo. Os métodos de processamento de sinal são baseados na aplicação de HAAR-CWT e MEXH-CWT aos espectros relativos com divisor duplo (DDRS). Estes espectros foram obtidos pela divisão do espectro de absorção do composto puro e suas misturas ternárias, por um divisor duplo ou espectro padrão correspondente à mistura de dois compostos em mistura ternária. O uso combinado de HAAR-CWT e MEXH-CWT com espectros relativos com divisor duplo (DDRS) foi denominado DDRS-HAAR CWT e DDRS-MEXH CWT. Para avaliar a habilidade ou aplicabilidade dos métodos desenvolvidos DDRS-CWT, foi aplicado como comparação, o método espectrofotométrico por derivada de espectros relativos com divisor duplo (DDRS-DS), às amostras mencionadas acima, contendo AA, ASP e PAR. Resultados satisfatórios foram obtidos.Simultaneous determination of ascorbic acid (AA), acetylsalicylic acid (ASP) and paracetamol (PAR) in their synthetic mixtures and effervescent tablets were performed by Haar and Mexican continuous wavelet transforms (HAAR-CWT and MEXH-CWT, respectively) together with double divisor technique. The signal processing methods are based on the application of HAAR-CWT and MEXH-CWT to the double divisor-ratio spectra (DDRS). These spectra were obtained by dividing the absorption spectra of pure compound and its ternary mixtures by a double-divisor or standard spectrum corresponding to a mixture of two compounds in ternary mixture. A combined use of HAAR-CWT and MEXH-CWT with double divisor-ratio spectra (DDRS) was denoted by DDRS-HAAR CWT and DDRS-MEXH CWT. To check the ability or applicability of the developed DDRS-CWT methods, the double divisor-ratio spectra-derivative spectrophotometric (DDRS-DS) method, as a comparison method, was applied to the above mentioned samples containing AA, ASP and PAR and satisfactory results were obtained.

Application of Single‐use Electrode Based on Nano‐clay and MWCNT for Simultaneous Determination of Acetaminophen, Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Dosage

“…To the best of our knowledge, the simultaneous analysis of PAR, A and ASA in pharmaceutical formulations have been carried out by using spectrophotometric and chromatographic methods. These methods have the difficulties of being time‐consuming, expensive and demanding qualified personnel.…”

Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures

“…e LOD and LOQ were calculated using the following equations: LOD= and LOQ= , σ is the standard deviation of residuals and S is the slope. 20 (15,20,25 μg/mL) for AML, ALI and HCT repeated three times in three days. d Robustness (n = 3), RSD of three laboratory prepared mixtures, analyzed at ±0.3 nm from the wavelength of determination.…”

“…Continuous Wavelet Transform was applied successfully in zero crossing and double divisor methods for analysis of ternary mixtures [14,15]. Fourier functions were also applied to double divisor method and used successfully for determination of ternary mixtures [16].…”

Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008

“…Derivative transform was applied to the original absorption signal together with its FWT generalization. Commercial tablets; no significant difference in the performance of the three methods regarding the accuracy and precision, respectively [166] Fenbufen; Ketoprofen By classical spectrophotometryzero-order derivative, 1st-and 2nd-order DS using "peak-peak" and, "peak-zero" measurements; in pharmaceuticals By ratio spectra first-order DS (graphical method) and chemometric method (numerical method, CLS); in the graphical approach, absorption spectra of QA and its binary mixtures in the selected spectral range of 210-280 nm were divided by standard spectrum of 10 g mL −1 HCT and their absorption spectra obtained, in the similar way, ratio spectra of HCT in region of 210-350 nm were obtained by using standard spectrum of 12 g mL −1 QA; 1st derivative of ratio spectra obtained in above steps calculated by = 5 nm interval for both drugs Lamivudine; Zidovudine Derivative-differential UV and compensation technique at 246 and 263 nm; also, HPLC; in human serum and pharmaceutical formulations -No differences were found between the methods [189] Levamizole; Oxyclozanide Numerical (PLS and PCR calibrations) and graphical (2nd-derivative spectrophotometry, amplitudes at 263.6 and 294 nm, respectively) methods; in bolus 5-25 for both drugs All proposed methods validated by using independent synthetic mixtures and standard addition technique [190] Loratadine; Pseudoephedrine By three different methods: (1) employs multi-wavelength spectroscopy using seven mixed standards and 257.0 and 283.0 nm as two wavelengths for estimation; (2) 1st derivative using 263.0 and 308.6 nm as zero-crossing points; (3) HPLC 0-40; 0-800 Results validated statistically and by recovery studies [191] Metformin; Pioglitazone 2nd derivative at 257.25 and 227.55 nm, respectively in spectra of their solutions in a mixture of methanol and acetonitrile (30:70) and HPLC; in combined dosage forms 4-20 for both drugs Both methods were validated and the results were compared statistically; they were found to be accurate, precise and specific [192] Routine analysis of both drugs in quality control laboratories [194] N-Butylscopolamine; Oxazepam 1st derivative by zero-crossing method at 226 and 257 nm, respectively; acetonitrile was selected as solvent in which both compounds showed well-defined bands; both analytes showed good stability in this solvent when their solutions were exposed to light and temperatures between 20 and [196] Paracetamol; Aceclofenac or Tramadol Zero-crossing point technique and the compensation technique; in combination solid dosage forms 0-24 for all drugs - [197] Paracetamol; Valdecoxib DS to eliminate spectral interference by measuring absorbances at two wavelengths 301 and 284 nm, respectively, in two-component tablet formulation -Results validated statistically and by recovery studies [198] Piracetam (PIR); Vincamine (VIN) By three different methods: (1) using ratio spectra 1st derivative at 209 and 293 nm; [202] Aspirin, Salicylic acid, Paracetamol 1st and 2nd derivatives of the ratio spectra and measurement at zero-crossing wavelengths. The ratio spectra were obtained by dividing the absorption spectrum of the mixture by that of one of the components; in synthetic mixtures and dosage forms 0.07-0....…”