Application of Factorial Design and Desirability Function to Develop a Single Analytical Procedure for the Determination of Metals in Different Tissues of Blue Crab (Callinectes danae)

Lima, Daniel C.; Guedes, Wesley Nascimento; Costa, Vinícius Câmara; Amorim, Fábio Alan Carqueija

doi:10.21577/0103-5053.20180064

Cited by 4 publications

(1 citation statement)

References 17 publications

(16 reference statements)

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“…DoE can be used for several applications depending on issue to be solved. In a review paper, Hibbert [11] described the use of several DoE processes applied to chromatographic separation and highlighted the most used in optimization and validation studies such as: (1) Factorial design [12][13][14]; (2) Plackett-Burman (PB) design [15][16][17]; (3) Central Composite design (CCD) [18][19][20]; (4) Box-Behnken design (BBD) [21][22][23]; (5) Doehlert design (DD) [24][25][26] and (6) Mixture design [27][28][29]. Other types of DoE have been used and often cited in the literature, as examples Mixed-level fractional factorial design [30][31][32]; Definitive Screening design (DSD) [33][34][35] and D-optimal design [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Key information related to quality by design (QbD) applications in analytical methods development

Araujo¹,

Andrade²,

Babos³

et al. 2020

Braz. J. Anal. Chem.

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In this review, quality by design (QbD) initiatives are described as applications for many types of processes, such as in the pharmaceutical industry, biotechnology field, and for analytical methods development. Design space (DS) and design of experiments (DoE) provide useful results for analytical methods development and simulation of advanced processes in traditional manufacturing relationships. The three topics, QbD, DS and DoE are the best way to achieve strong and efficient industrial production.

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