Application of Cell Extracts from Skin, Placenta, Mesenchyme with Collagen and Elastin in Aesthetic Dermatology and Skin Revitalization: Evaluation of Outcomes in Cohort Study

Abstract

Aging-related changes of the skin are characterized by reduction of the elasticity, moistness and thickness, appearance of wrinkles, pigmented spots, lentigos, and keratosis. Histological changes include thinning of epidermis, flattening of epidermal-dermal interface, reduction of production and disorganization of collagen and elastin, slowdown of cell turnover, reduction of melanocytes and their erratic activity and the phenomenon of solar elastosis.The objectives of the study were to evaluate the efficacy of mesotherapy with a cocktail containing combination of cell extracts from skin, placenta and mesenchyme with addition of collagen and elastin proteins in rejuvenation and revitalization of the facial skin. The cohort comprised of 26 women in the age 40-65 y.o. (mean age 56 ± 2.5) with Fitzpatrick skin types III and IV and Glogau score II-III. Treatment consisted of mesotherapy applied on the forehead, cheeks, periorbital and perioral areas, chin and neck. The injected formulation was MF+ Mito Organelles™ SPMCE -peptide-extracts from skin, placenta, mesenchyme, with collagen and elastin. Treatment sessions were performed across 12 weeks at weekly intervals. Final results were assessed 1 and 3 months after the last mesotherapy session using photographic comparison and patient's subjective view and external dermatologist-expert's opinion, clinical and instrumental evaluation, and histopathology report. Clinical and histochemical data obtained from the study confirms the anti-aging properties of the used product. Analysis of dermal elastic filaments has proven the reduction of skins roughness and determined the bio-revitalizing and rejuvenating effect of the used product. Study has demonstrated MF+ MO™ SPMCE capacity to promote biosynthesis of new collagen and elastic fibers. The improvements in skin hydration and dramatic reduction of senile lentigo and uneven pigmentation were noted. Obtained data allow to conclude that application of MF+ MO™ SPMCE cellular extracts/peptides in mesotherapy can be considered as safe and effective method of facial rejuvenation.

Trends in biopolymer science applied to cosmetics

“…Mesotherapy is another area of cosmetics where elastin may be an excellent candidate for enhancing skin restoration and achieving healthy, young-looking skin. Klokol et al (2016) analysed the performance of a cocktail containing cell extracts from the placenta, skin and mesenchyme with collagen and elastin on 26 women aged 40-65. They concluded that the cocktail had an overall effect as an anti-ageing product because it promoted biosynthesis of new collagen and elastin fibres, reduced senile lentigos and non-uniform pigmentation and decreased skin roughness [52].…”

Stem Cell Therapy for Aging Related Diseases and Joint Diseases in Companion Animals

“…Stem cells also possess the capacity to generate peptides that hold potential for therapeutic applications in the treatment of various diseases. For example, the clinical outcomes of organ-specific mammalian precursor stem cell-derived peptide preparations [6][7][8], manufactured by European Wellness laboratories, have been documented in both historical and scientific journals [9][10][11] across a wide range of diseases and illnesses where treatment options are limited.…”