Application of aptamer functionalized nanomaterials in targeting therapeutics of typical tumors

Yin, Xiu-Juan; He, Zhenqiang; Ge, Weiying; Zhao, Zhenhua

doi:10.3389/fbioe.2023.1092901

Cited by 4 publications

(2 citation statements)

References 186 publications

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“…Sanjanwala et al conducted a review on aptamers and nanobodies as ligands for targeted drug delivery in cancer, particularly mentioning drug delivery systems utilizing the AS1411 aptamer [ 113 ]. Yin et al reviewed drug delivery systems using aptamers as functionalizing agents for therapeutics in various types of cancer [ 144 ], and Li et al reviewed the application of aptamers as drug-delivery carriers related to adenocarcinoma [ 145 ]. These reviews mention the delivery system developed by Wang et al, specifically a micelle containing triptolide functionalized with the AS1411 aptamer, demonstrating the superior efficacy of the aptamer-functionalized micelle compared with the non-functionalized micelle in tumor growth in vivo [ 146 ].…”

Section: Current Plant-based Natural Products Aptamers and Delivery S...mentioning

confidence: 99%

Aptamers for the Delivery of Plant-Based Compounds: A Review

Gamboa,

Lourenço,

Cruz

et al. 2024

Pharmaceutics

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Natural compounds have a high potential for the treatment of various conditions, including infections, inflammatory diseases, and cancer. However, they usually present poor pharmacokinetics, low specificity, and even toxicity, which limits their use. Therefore, targeted drug delivery systems, typically composed of a carrier and a targeting ligand, can enhance natural product selectivity and effectiveness. Notably, aptamers—short RNA or single-stranded DNA molecules—have gained attention as promising ligands in targeted drug delivery since they are simple to synthesize and modify, and they present high tissue permeability, stability, and a wide array of available targets. The combination of natural products, namely plant-based compounds, with a drug delivery system utilizing aptamers as targeting agents represents an emerging strategy that has the potential to broaden its applications. This review discusses the potential of aptamers as targeting agents in the delivery of natural compounds, as well as new trends and developments in their utilization in the field of medicine.

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Section: Current Plant-based Natural Products Aptamers and Delivery S...mentioning

confidence: 99%

Aptamers for the Delivery of Plant-Based Compounds: A Review

Gamboa,

Lourenço,

Cruz

et al. 2024

Pharmaceutics

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“…Aptamers have many potential applications in nanotechnology to treat diseases. They are particularly useful in this context due to their small size, allowing them to be used in drug delivery devices without significantly increasing the device's overall size and allowing for cell or tissue selectivity 55 . Aptamers potentially work for a large range of potential drug delivery due to their capability to connect to various targets, such as hepatitis C virus proteins, thrombin, HIV-1, and human thyroid-stimulating hormone.…”

Section: Aptamer-assisted Nanotechnologymentioning

confidence: 99%

Aptamer-engineered (nano)materials for theranostic applications

Rabiee,

Chen,

Ahmadi

et al. 2023

Theranostics

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A diverse array of organic and inorganic materials, including nanomaterials, has been extensively employed in multifunctional biomedical applications. These applications encompass drug/gene delivery, tissue engineering, biosensors, photodynamic and photothermal therapy, and combinatorial sciences. Surface and bulk engineering of these materials, by incorporating biomolecules and aptamers, offers several advantages such as decreased cytotoxicity, improved stability, enhanced selectivity/sensitivity toward specific targets, and expanded multifunctional capabilities. In this comprehensive review, we specifically focus on aptamer-modified engineered materials for diverse biomedical applications. We delve into their mechanisms, advantages, and challenges, and provide an in-depth analysis of relevant literature references. This critical evaluation aims to enhance the scientific community's understanding of this field and inspire new ideas for future research endeavors.

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