Application of Apatite Coated Titanium Dioxide

Nonami, Toru; Funakoshi, Kunio; Hase, Hiroko; Tone, Kisato

doi:10.4139/sfj.55.335

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydroxyapatite is soluble at lower pH and insoluble at higher pH. 28,29 It is suggested that the composite gel containing hydroxyapatite decreased in size as much as the alginate gel in HCl solution did, and the composite gel did not increase much in size in the NaOH solution. In the process of absorption of hydroxyapatite in vivo, hydroxyapatite must be dissolved.…”

Section: Evaluation Of the Stimulus Response S Obara Et Almentioning

confidence: 99%

Evaluation of the stimulus response of hydroxyapatite/ calcium alginate composite gels

Obara

Yamauchi

Tsubokawa

2010

Polym J

View full text Add to dashboard Cite

Stimuli-responsive gels have been actively studied and applied to a variety of devices such as drug carriers, artificial muscles and actuators. In this research study, calcium alginate gels containing hydroxyapatite were prepared in one step by adding a diammonium hydrogenphosphate-1% alginate solution to a calcium chloride solution and evaluated for pH dependence and electrochemical properties as stimuli-responsive gels. When the composite gel was immersed in a solution of pH 2-10 or subjected to an applied voltage, the composite gel with a high content of hydroxyapatite tended to maintain its volume. The composite gels immersed in a pH indicator solution changed color with an applied voltage. As a result, it was revealed that alteration of the pH of composite gels occurred by electro-osmosis and electrophoresis. Swelling and shrinking of the composite gels were controlled by the external stimuli of pH, voltage and the content of hydroxyapatite; therefore, it is proposed that composite gels would be good bone-filling material having the function of drug carriers.

show abstract

Section: Evaluation Of the Stimulus Response S Obara Et Almentioning

confidence: 99%