Application of a quartz-crystal microbalance for detection of phase transitions in liquid crystals and lipid multibilayers

Okahata, Yoshio; Ebato, Hiroshi

doi:10.1021/ac00194a014

Cited by 68 publications

(23 citation statements)

References 16 publications

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“…Thickness-shear-mode acoustic wave devices have been used successfully to follow phase transitions in liquid crystals and lipid multilayers. 85 Rajakovic et ~1.86 examined the role of the device-to-water acoustic interaction and, accordingly, the part played by interfacial viscosity in determining the frequency response. Frequency measurements in water for TSM sensors with gold, aluminium and silanized aluminium electrodes were obtained by the oscillator method.…”

Section: Properties Of Thin Filmsmentioning

confidence: 99%

Thickness-shear-mode acoustic wave sensors in the liquid phase. A review

Thompson¹,

Kipling²,

Duncan-Hewitt³

et al. 1991

Analyst

320

150

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Section: Properties Of Thin Filmsmentioning

confidence: 99%

Thickness-shear-mode acoustic wave sensors in the liquid phase. A review

Thompson¹,

Kipling²,

Duncan-Hewitt³

et al. 1991

Analyst

320

150

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“…The immobilization of the membrane at a surface permits rapid exchange of the fluids in contact with the membrane. It allows the application of surface-sensitive probes such as surface plasmon resonance (SPR) (Ohlsson et al, 1995;Stelzle et al, 1993;Striebel et al, 1994), total internal reflection fluorescence microscopy (TIRFM) (Kalb et al, 1992), impedance spectroscopy (Steinem et al, 1996), and acoustic sensors such as the quartz crystal microbalance (QCM) (Ohlsson et al, 1995;Okahata and Ebato, 1989) and surface acoustic wave (SAW) devices (Gizeli et al, 1996). The intrinsically low bioactivity, i.e., low degree of nonspecific adsorptivity (Heyse et al, 1995;Janshoff et al, 1996;McConnell et al, 1986;Stelzle et al, 1993), of supported membranes makes them interesting as an inter-face between the nonbiological materials on the surface of a sensor or implant and biologically active fluids.…”

Section: Introductionmentioning

confidence: 99%

Surface Specific Kinetics of Lipid Vesicle Adsorption Measured with a Quartz Crystal Microbalance

Keller

Kasemo

1998

Biophysical Journal

939

141

1,234

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We have measured the kinetics of adsorption of small (12.5-nm radius) unilamellar vesicles onto SiO2, oxidized gold, and a self-assembled monolayer of methyl-terminated thiols, using a quartz crystal microbalance (QCM). Simultaneous measurements of the shift in resonant frequency and the change in energy dissipation as a function of time provide a simple way of characterizing the adsorption process. The measured parameters correspond, respectively, to adsorbed mass and to the mechanical properties of the adsorbed layer as it is formed. The adsorption kinetics are surface specific; different surfaces cause monolayer, bilayer, and intact vesicle adsorption. The formation of a lipid bilayer on SiO2 is a two-phase process in which adsorption of a layer of intact vesicles precedes the formation of the bilayer. This is, to our knowledge, the first direct evidence of intact vesicles as a precursor to bilayer formation on a planar substrate. On an oxidized gold surface, the vesicles adsorb intact. The intact adsorption of such small vesicles has not previously been demonstrated. Based on these results, we discuss the capacity of QCM measurements to provide information about the kinetics of formation and the properties of adsorbed layers.

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“…Many analytical applications in gas sensing [2,7], trace ion determination [8], immunoassay [9,10], viscosity monitoring in bioprocesses [11,12,13,14], and electrochemical examinations [15,16,17,18,19] have been published [20]. Phase-transition phenomena of liquid crystals [21,22], lipid multi-bilayer films [23], Langmuir-Blodgett (LB) films [24], and blend polymers [25] have also been studied using the quartz crystal and surface acoustic wave devices. The importance of studying viscoelastic phenomena with coated films originated, especially, in the field of the electrochemical analysis, from the desire to clarify the causes of the resonant frequency change in viscoelastic films [17,26].…”

Section: Introductionmentioning

confidence: 99%

Quartz-crystal sensors for biosensing and chemical analysis

Muramatsu

Kim

Chang

2002

Analytical and Bioanalytical Chemistry

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The principle and applications of quartz-crystal sensors based on the three basic concepts for mass, viscosity, and viscoelastic changes are reported. In the general discussion the realization of a resonant frequency-resonant resistance diagram is described in detail. As an example of application to mass sensing, gas sensing with a carbon-coated quartz crystal is reported. Determination of the blood coagulation factor is used as an example of the application to viscosity sensing. As an example of viscoelastic measurement, an ion-exchange polymer-coated quartz crystal is investigated to show that viscoelasticity changes more than mass in the transport process. The possibility of developing new biosensors and chemical sensors is discussed on the basis of these results.

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Application of a quartz-crystal microbalance for detection of phase transitions in liquid crystals and lipid multibilayers

Cited by 68 publications

References 16 publications

Thickness-shear-mode acoustic wave sensors in the liquid phase. A review

Thickness-shear-mode acoustic wave sensors in the liquid phase. A review

Surface Specific Kinetics of Lipid Vesicle Adsorption Measured with a Quartz Crystal Microbalance

Quartz-crystal sensors for biosensing and chemical analysis

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