Application of a Prognostic Scale to Estimate the Mortality of Children Hospitalized with Community-acquired Pneumonia

Araya, Soraya; Lovera, Dolores; Zarate, Claudia; Apodaca, Silvio; Acuña, Julia; Sanabria, Gabriela; Arbo, Antonio

doi:10.1097/inf.0000000000001018

Cited by 44 publications

(59 citation statements)

References 10 publications

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“…In accordance with the previous statement, in our non-systematic bibliographic research for the currently available scores, we have found three severity scores in pediatric populations, the Respiratory Index of Severity Score (RISC), 3 the Pediatric Respiratory Severity Score (PRESS), 4 and the Predisposition, Insult, Response, Organ dysfunction modified (PIROm) 5 which are compared in Table 1.…”

Section: Mortality Predictive Scores For Community-acquired Pneumoniasupporting

confidence: 73%

“…The PIROm score does not only evaluate clinical criteria, but also collects radiological and laboratory data obtained from clinical records. Moreover, this score is the only instrument created from another score used from the adult population (PIRO) …”

Section: Severity Predictive Scores For Community‐acquired Pneumoniamentioning

confidence: 99%

“…Moreover, this score is the only instrument created from another score used from the adult population (PIRO). 5 The main problem is the scarcity of information about scores that assess the severity of pneumonia in pediatric patients, its application and use in different populations, and their usefulness implementation in different levels of health care.…”

Section: Mortality Predictive Scores For Community-acquired Pneumoniamentioning

confidence: 99%

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Mortality predictive scores for community-acquired pneumonia in children

Fernández-Mormontoy

Estremadoyro-Gallardo

Vargas

2017

Pediatr Pulmonol

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Section: Mortality Predictive Scores For Community-acquired Pneumoniasupporting

confidence: 73%

Section: Severity Predictive Scores For Community‐acquired Pneumoniamentioning

confidence: 99%

Section: Mortality Predictive Scores For Community-acquired Pneumoniamentioning

confidence: 99%

See 1 more Smart Citation

Mortality predictive scores for community-acquired pneumonia in children

Fernández-Mormontoy

Estremadoyro-Gallardo

Vargas

2017

Pediatr Pulmonol

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“…Patients were evaluated through full history, general examination, and local examination of the chest to detect signs of lower respiratory tract infection and those indicating respiratory distress, e.g., chest indrawing. Moreover, pneumonia severity was assessed by some clinical scoring systems, namely the Pediatric Respiratory Severity Score (PRESS) score [14]; Predisposition, Infection, Response and Organ failure (PIROm) score [15]; Respiratory Index of Severity in Children (RISC) score, and the WHO classification [16]. Laboratory investigations included complete blood count (CBC), C-reactive protein (CRP), blood gas analysis, serum electrolytes, and renal function tests.…”

Section: Methodsmentioning

confidence: 99%

The role of Tumor necrosis factor alpha −308 G>A promoter polymorphism in pediatric community acquired pneumonia

Gendy

El-Mekkawy

El-Naidany

et al. 2020

Egypt Pediatric Association Gaz

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Background: Tumor necrosis factor alpha (TNF-α) −308 G>A promoter polymorphism might be associated with excessive production of the proinflammatory cytokine TNF-α, modulating host response to pulmonary infections. Our objective was to evaluate the association of TNF-α gene −308 G>A polymorphism with susceptibility to, and severity of, community-acquired pneumonia (CAP).Results: This was a cross-sectional study including 45 Egyptian children hospitalized for CAP in addition to 45 healthy children who served as a control group. Pneumonia severity was assessed on admission by the World Health Organization (WHO) guidelines; Pediatric Respiratory Severity Score (PRESS) score; Predisposition, Infection, Response and Organ failure (PIROm) score; and Respiratory Index of Severity in Children (RISC) score. Genotyping of TNF-α polymorphism was performed to all individuals by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Patients were monitored till hospital discharge. Frequency of AG genotype was lower among patients compared with control [odds ratio (OR) and 95% confidence interval (CI) = 0.13 (0.03-0.63); p = 0.012]. Prevalence of genotypes AA+AG was lower among patients compared with controls [OR and 95% CI = 0.34 (0.12-0.99); p = 0,048]. The "A" allele prevalence was higher among controls, but no significant association was found with CAP [OR and 95% CI = 0.58 (0.25-1.35); p = 0.21]. When PRESS score was used to classify patients into "severe pneumonia" and "non-severe pneumonia," no significant association of any of the alleles or genotypes with CAP severity was found.Conclusion: TNF-α −308 G>A polymorphism confers protection from pediatric CAP but is not associated with indicators of CAP severity. Larger studies are needed to confirm these findings in pediatric patients from different ethnicities.

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“…Hier gehen Parameter wie junges Lebensalter (< 6 Monate), Komorbidität, Hypoxämie (SaO 2 < 90 %), arterielle Hypotension, nachgewiesene Bakteriämie, Schwere der Lungenaffektion und extrapulmonale Störungen (z. B. renale oder hepatische Dysfunktion) ein [159,160]. Die derzeit verfügbaren Scores spielen zwar eher in klinischen Studien eine Rolle, können aber auch im Klinikalltag die Entscheidung zur Verlegung auf eine Intensivstation unterstützen.…”

Section: Lungenversagenunclassified

S2k-Leitlinie Management der ambulant erworbenen Pneumonie bei Kindern und Jugendlichen (pädiatrische ambulant erworbene Pneumonie, pCAP)

et al. 2020

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ZusammenfassungDie vorliegende Fassung der deutschsprachigen AWMF-Leitlinie soll unter Berücksichtigung der vorliegenden Evidenz die medizinische Versorgung von Kindern und Jugendlichen mit ambulant erworbener Pneumonie (pediatric community acquired pneumonia, pCAP) verbessern. In Mitteleuropa steht einer Prävalenz von ca. 300 Fällen pro 100 000 Kinder/Jahr eine sehr geringe Mortalität gegenüber, die Prävention umfasst Hygiene-Maßnahmen und Impfung z. B. gegen Pneumokokken, Hämophilus, Masern und Influenza. Hauptsymptome der pCAP sind Fieber und Tachypnoe, die Diagnosestellung erfolgt primär klinisch durch Anamnese, körperliche Untersuchung und Pulsoxymetrie. Das zusätzliche Vorliegen von Warnsymptomen wie stark reduzierter Allgemeinzustand, Nahrungsverweigerung, Dehydratation, Bewusstseinsstörung oder Krampfanfälle definiert die schwere pCAP in Abgrenzung zur nicht-schweren pCAP. Das Erregerspektrum ist altersabhängig, zur Differenzierung zwischen viraler, bakterieller oder gemischt viral-bakterieller Infektion stehen jedoch keine zuverlässigen Biomarker zur Verfügung. Die meisten Kinder und Jugendlichen mit nicht-schwerer pCAP und O2-Sättigung > 92 % können ohne weitere Röntgen-, Labor- und Erreger-Diagnostik ambulant betreut werden. Der Einsatz von Antiinfektiva ist nicht grundsätzlich indiziert, vor allem bei jungen Kindern, bronchialer Obstruktion und anderen Hinweisen auf virale Genese kann darauf i. d. R. verzichtet werden. Zur kalkulierten Antibiotika-Therapie sind Aminopenicilline Mittel der Wahl, bei gewährleisteter Einnahme und Resorption sind die orale (Amoxicillin) und intravenöse Verabreichung (Ampicillin) von vergleichbarer Wirksamkeit. Nach 48 – 72 Stunden ist eine Verlaufsbeurteilung notwendig, um den Behandlungserfolg und mögliche Komplikationen wie z. B. parapneumonische Ergüsse oder Pleuraempyeme, die eine Erweiterung bzw. Änderung der Therapie erforderlich machen, rechtzeitig zu erfassen.

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Application of a Prognostic Scale to Estimate the Mortality of Children Hospitalized with Community-acquired Pneumonia

Abstract: The present score accurately discriminated the probability of death in children hospitalized with CAP, and it could be a useful tool to select candidates for admission to intensive care unit and for adjunctive therapy in clinical trials.

Cited by 44 publications

References 10 publications

Mortality predictive scores for community-acquired pneumonia in children

Mortality predictive scores for community-acquired pneumonia in children

The role of Tumor necrosis factor alpha −308 G>A promoter polymorphism in pediatric community acquired pneumonia

S2k-Leitlinie Management der ambulant erworbenen Pneumonie bei Kindern und Jugendlichen (pädiatrische ambulant erworbene Pneumonie, pCAP)

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