Apple peel flavonoid- and triterpene-enriched extracts differentially affect cholesterol homeostasis in hamsters

Thilakarathna, Surangi H.; Wang, Yanwen; Rupasinghe, H.P. Vasantha; Ghanam, Khadija

doi:10.1016/j.jff.2012.07.004

Cited by 25 publications

(10 citation statements)

References 36 publications

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“…In addition, HPβ-CD was also ineffective in the extraction of phenolic acids, representing merely 12 % of the amount recovered using β-CD, respectively. Flavonols, such as quercetin glycosides, are a subclass of flavonoids, which find importance owing to their health promoting effect such as anti-oxidant ); antihypertensive (Balasuriya and Rupasinghe 2012), anti-diabetic (Panicker et al 2010); anti-atherosclerelotic (Thilakarathna et al 2012), neuroprotective (Jones et al 2012) and chemopreventive effects via anti-mutagenic, anti-oxidant, antiinflammatory and anti-proliferative activities (Gerhäuser 2008;Gerhäuser et al 2003;Murakami et al 2008;Murphy et al 2012). Therefore, the extraction of quercetin glycosides deserves special attention in terms of yield, eco-friendly aspects and physio-chemical properties.…”

Section: Resultsmentioning

confidence: 99%

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

2014

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The present study investigated five cyclodextrins (CDs) for the extraction of flavonols from apple pomace powder and optimized β-CD based extraction of total flavonols using response surface methodology. A 2(3) central composite design with β-CD concentration (0-5 g 100 mL(-1)), extraction temperature (20-72 °C), extraction time (6-48 h) and second-order quadratic model for the total flavonol yield (mg 100 g(-1) DM) was selected to generate the response surface curves. The optimal conditions obtained were: β-CD concentration, 2.8 g 100 mL(-1); extraction temperature, 45 °C and extraction time, 25.6 h that predicted the extraction of 166.6 mg total flavonols 100 g(-1) DM. The predicted amount was comparable to the experimental amount of 151.5 mg total flavonols 100 g(-1) DM obtained from optimal β-CD based parameters, thereby giving a low absolute error and adequacy of fitted model. In addition, the results from optimized extraction conditions showed values similar to those obtained through previously established solvent based sonication assisted flavonol extraction procedure. To the best of our knowledge, this is the first study to optimize aqueous β-CD based flavonol extraction which presents an environmentally safe method for value-addition to under-utilized bio resources.

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Section: Resultsmentioning

confidence: 99%

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

2014

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“…Previous literature shows evidence that flavonoids (proanthocyanidins as an example) are antioxidants [3] and hypocholesterolemic compounds [4] as well as modulators of cell signaling and gene expression in different experimental models [5] and in human epidemiological studies [6]. Considering the distribution of flavonoids, some classes can be found in many foods whereas the presence of some classes is limited to certain foods.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

2013

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Flavonoids are a group of phytochemicals that have shown numerous health effects and have therefore been studied extensively. Of the six common food flavonoid classes, flavonols are distributed ubiquitously among different plant foods whereas appreciable amounts of isoflavones are found in leguminous plant-based foods. Flavonoids have shown promising health promoting effects in human cell culture, experimental animal and human clinical studies. They have shown antioxidant, hypocholesterolemic, anti-inflammatory effects as well as ability to modulate cell signaling and gene expression related disease development. Low bioavailability of flavonoids has been a concern as it can limit or even hinder their health effects. Therefore, attempts to improve their bioavailability in order to improve the efficacy of flavonoids are being studied. Further investigations on bioavailability are warranted as it is a determining factor for flavonoid biological activity.

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“…Hitherto, the efficacy of flavonoids has been shown against different diseases including diabetes, cancers, and cardiovascular diseases (23). Flavonoids exert their beneficial effects via different mechanisms including antioxidant and hypocholesterolemic activities as well as modulatory effects on various cell signaling pathways and gene expression (24)(25)(26)(27).…”

Section: Flavonoidsmentioning

confidence: 99%

The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

Razavi-Azarkhiavi

Iranshahy

Sahebkar

et al. 2016

Nutrition and Cancer

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Although doxorubicin (DOX) is among the most widely used anticancer agents, its clinical application is hampered owing to its cardiotoxicity. Adjuvant therapy with an antioxidant has been suggested as a promising strategy to reduce DOX-induced adverse effects. In this context, many phenolic compounds have been reported to protect against DOX-induced cardiotoxicity. The cardioprotective effects of phenolic compounds are exerted via multiple mechanisms including inhibition of reactive oxygen species generation, apoptosis, NF-κB, p53, mitochondrial dysfunction, and DNA damage. In this review, we present a summary of the in vitro, in vivo, and clinical findings on the protective mechanisms of phenolic compounds against DOX-induced cardiotoxicity.

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Apple peel flavonoid- and triterpene-enriched extracts differentially affect cholesterol homeostasis in hamsters

Cited by 25 publications

References 36 publications

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

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