The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

Razavi-Azarkhiavi, Kamal; Iranshahy, Milad; Sahebkar, Amirhossein; Shirani, Kobra; Karimi, Gholamreza

doi:10.1080/01635581.2016.1187280

Cited by 64 publications

(39 citation statements)

References 160 publications

(180 reference statements)

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“…Doxorubicin exhibits toxic effects on cancer cells by intercalating with DNA, by disrupting topoisomerase II-mediated DNA damage repair, and by releasing reactive oxygen species leading to oxidative stress and programmed cell death 42. However, it suffers from serious limitations of cardiotoxicity and drug resistance.…”

Section: Curcumin As a Combinatorial Therapy In Various Cancer Typesmentioning

confidence: 99%

New insights into therapeutic activity and anticancer properties of curcumin

Panda¹,

Chakraborty²,

Sarkar³

et al. 2017

JEP

160

103

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Natural compounds obtained from plants are capable of garnering considerable attention from the scientific community, primarily due to their ability to check and prevent the onset and progress of cancer. These natural compounds are primarily used due to their nontoxic nature and the fewer side effects they cause compared to chemotherapeutic drugs. Furthermore, such natural products perform even better when given as an adjuvant along with traditional chemotherapeutic drugs, thereby enhancing the potential of chemotherapeutics and simultaneously reducing their undesired side effects. Curcumin, a naturally occurring polyphenol compound found in the plant Curcuma longa, is used as an Indian spice. It regulates not only the various pathways of the immune system, cell cycle checkpoints, apoptosis, and antioxidant response but also numerous intracellular targets, including pathways and protein molecules controlling tumor progression. Many recent studies conducted by major research groups around the globe suggest the use of curcumin as a chemopreventive adjuvant molecule to maximize and minimize the desired effects and side effects of chemotherapeutic drugs. However, low bioavailability of a curcumin molecule is the primary challenge encountered in adjuvant therapy. This review explores different therapeutic interactions of curcumin along with its targeted pathways and molecules that are involved in the regulation of onset and progression of different types of cancers, cancer treatment, and the strategies to overcome bioavailability issues and new targets of curcumin in the ever-growing field of cancer.

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Section: Curcumin As a Combinatorial Therapy In Various Cancer Typesmentioning

confidence: 99%

New insights into therapeutic activity and anticancer properties of curcumin

Panda¹,

Chakraborty²,

Sarkar³

et al. 2017

JEP

160

103

View full text Add to dashboard Cite

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“…PARP cleavage was used to detect DNA damage in the cell cultures (PE Mouse Anti-Cleaved PARP, Asp214; BD Biosciences, San Diego, CA, USA). Curcumin (30 µM) and/or paclitaxel (10 nM) were added per 1x10 6 proliferating breast cells. Cells were incubated for 48 h at 37˚C.…”

Section: -Amino Actinomycin D (7-a Ad)/annexin V Assaymentioning

confidence: 99%

“…Currently, treatment with conventional chemotherapeutic drugs for breast cancer is limited, due to issues including poor solubility and multidrug resistance (4). Challenges in breast cancer treatment include the combinations of chemotherapeutic drugs that lead to adverse effects, a high level of heterogeneity from patient to patient, and long-term drug administration, with resistance and recurrence of cancer following treatment (5,6).…”

Section: Introductionmentioning

confidence: 99%

Curcumin and paclitaxel induce cell death in breast cancer cell lines

2018

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Breast cancer is one of the major health issues confronting women; however, treatment with conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a therapeutic clinical agent to treat breast cancer that exerts antitumor activity in numerous types of cancer cell. Curcumin (diferuloylmethane), a polyphenol derived from turmeric (Curcuma longa), possesses several properties that could enable it to exert an anticancer effect. Previous reports have demonstrated the synergistic effects of several chemotherapeutic drugs in combination with curcumin. Therefore, the aim of the current study was to evaluate cell death induced by curcumin and paclitaxel alone and in combination in human breast cancer cell lines: MCF7, an epithelial and luminal-like adenocarcinoma cell line triple positive for estrogen and progesterone receptor, and MDA-MB-234, a metastatic human breast cancer cell line triple negative for such receptors, as well as MCF-10F as a normal breast cell line. The results indicated that curcumin and paclitaxel induced apoptosis and necrosis, which was demonstrated through multiple methods, including assays of caspase-3/7 activity, Annexin V, poly(ADP-ribose) polymerase-1 activation and protein expression of caspase-3, nuclear factor (NF)-κB transcription factor and proliferating cell nuclear antigen. The results identified that the combination of curcumin and paclitaxel had a decreased effect on apoptosis in the malignant MDA-MB-231 cell line compared with in MCF7 or MCF-10F. It was demonstrated that the combined treatment with curcumin and paclitaxel resulted in a higher level of apoptosis compared with either substance alone in breast cancer cell lines. Therefore, breast cancer treatment may benefit from the use of a combination of drugs in chemotherapy.

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“…In addition to its antimicrobial effects (Stagos et al, 2012b), resveratrol has been reported to have psychological activity including cognitive capability associated with dementia, and antioxidant activity as well as cardiovascular health (Goutzourelas et al;2015,Fenga et al;2016,Hashemzaei et al;2016, Sinha et al;2016, Razavi-Azarkhiavi et al;.…”

Section: Resveratrol: Well-known Monomeric Stilbenementioning

confidence: 99%

Resveratrol as MDR reversion molecule in breast cancer: An overview

Alamolhodaei

Tsatsakis

Ramezani

et al. 2017

Food and Chemical Toxicology

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Breast cancer is the most common cause of cancer mortality among women worldwide; therefore, a strategy to defeat breast cancer is an extremely important medical issue. One of the major challenges in this regard is multidrug resistance (MDR). Resveratrol, a well-known phytoestrogen, may be helpful as part of an overall strategy to defeat breast cancer. The mixed agonist and antagonist role of resveratrol for the estrogen receptor makes it a controversial but interesting molecule in cancer therapy, especially in hormone dependent cancers. Several in vitro investigations have suggested that resveratrol can reverse multidrug resistance. However, poor bioavailability of resveratrol is a potential limitation for resveratrol treatment and cancer outcome in vivo. Fortunately, combination therapy with other selected compounds improves resveratrol's bioavailability and/or a delay in its metabolism. This review summaries the available published literature dealing with the effects of resveratrol on multidrug resistance in cancer and more specifically, breast cancer.

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The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

Cited by 64 publications

References 160 publications

New insights into therapeutic activity and anticancer properties of curcumin

New insights into therapeutic activity and anticancer properties of curcumin

Curcumin and paclitaxel induce cell death in breast cancer cell lines

Resveratrol as MDR reversion molecule in breast cancer: An overview

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