Appendiceal goblet cell carcinoids: a clinicopathological and immunohistochemical study

Abstract

Goblet cell carcinoids are uncommon but distinctive tumours of the appendix. We have reviewed 11 cases diagnosed within the period 1976-1990. The mean age at presentation was 58 years (range 24-76), with a female:male ratio of 8:3. At presentation, in seven patients tumour was confined to the appendix or mesoappendix (mean age 51) and in four there was extension beyond the appendix (mean age 69). Of the seven patients with localized tumour, six are alive and without clinical disease after a mean follow-up period of 32 months and one died with recurrent tumour after 10 years. Of the four with more extensive disease, two died during follow-up (at 23 months with probable liver metastases and at 16 months with intestinal obstruction) and two are alive, one with disease and one clinically disease-free. Immunohistochemistry showed that all of the tumours stained positively for either neuron-specific enolase, chromogranin A or protein gene product 9.5. No tumour stained with antiserum to substance P and none showed glucagon-like immunoreactivity, but four cases stained positively for pancreatic polypeptide, an unusual feature in midgut carcinoids.

Goblet cell carcinoid tumors of the appendix: An overview

“…The ageadjusted annual incidence of appendiceal malignancies is 0.12 cases per million [19,20] . The age of presentation ranges from 18 to 89 years with the majority of patients presenting in their fifth or sixth decades [14,19,21] . This contrasts with the average age of presentation for malignant carcinoids (38 years) and adeno carcinoma of the appendix (62 years) [19] .…”

Goblet cell carcinoid of the appendix accompanied by adenomatous polyp with high-grade dysplasia at the cecum

“…Carcinoembriyonic antigen (CEA) has been found to be increased in metastatic cases (11). GCC can cause various complaints, such as abdominal mass, mesenteric lymphadenitis, and gastrointestinal bleeding (8,9,17). These tumors may rarely lead to pseudomyxoma peritonei, similar to other mucinous tumors.…”

Goblet cell carcinoid of the appendix: a case report

“…Sıklıkla 5-6. dekatlarda görülen bu tümörler, olgumuzda olduğu gibi sıklıkla akut karın şikayeti ile hastaneye başvuran ve akut apendisit tanısıyla operasyona alınan hastaların apendektomi materyalinin histopatolojik incelenmesiyle tanınırlar (3,4,12,(14)(15)(16). Karakteristik histolojik görünümlerine ek olarak bizim olgumuzda da görüldüğü gibi mezoapendikse yaygın invazyon ve perinöral invazyon gösterirler (5,6).…”

“…Bu tümörler kromogranin A, sinaptofizin, serotonin, enteroglukagon gibi nöroendokrin belirleyicilerin pozitifliğinin yanısıra intestinal tip müsin glikoprotein (MUC2) ekspresyonu da gösterirler (3,5,7,15,17). Goblet hücrelerin-de ayrıca CK 7, CK 19, CK 20 pozitiftir (1,3).…”

“…Olguların %20'sinde peritoneal karsinomatozis gelişir. Karaciğer, barsak duvarı, rektum, pankreas ve akciğere metastaz bildirilmiştir (4,6,7,11,15).…”