Goblet cell carcinoid of the appendix accompanied by adenomatous polyp with high-grade dysplasia at the cecum

Özemir, İbrahim Ali; Baysal, Hakan; Zemherı, Ebru; Bilgiç, Çağrı; Yiğitbaşı, Rafet; Ali̇moğlu, Orhan

doi:10.5152/ucd.2016.3348

Cited by 2 publications

(1 citation statement)

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“…Despite its mixed phenotype, GCA is officially recognized as a subtype of adenocarcinoma in the current WHO given its aggressive biologic behavior that is akin to adenocarcinoma[ 14 , 48 ]. GCA may co-exist with adjacent cecal adenoma[ 49 ]. Therefore, it is possible that cecal adenoma with underlying GCA may be interpreted as CIAM.…”

Section: Differential Diagnosismentioning

confidence: 99%

Composite intestinal adenoma-microcarcinoid: An update and literature review

Fu¹,

Kmeid²,

Aldyab³

et al. 2021

WJGE

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Composite intestinal adenoma-microcarcinoid (CIAM) is a rare intestinal lesion consisting of conventional adenoma and small, well differentiated carcinoid [microcarcinoid (MC)] at its base. The incidence of CIAM is 3.8% in surgically resected colorectal polyps. While its pathogenesis is unknown, studies support the role of Wnt/β-catenin pathway in the tumorigenesis of CIAM. CIAMs have been primarily reported in the colon wherein they present as polyps with well-defined margins, similar to conventional adenomatous polyps. MC is usually found in adenomatous polyps with high-risk features such as large size, villous architecture, or high grade dysplasia. Histologically, the MC component is often multifocal and spans 3.9 to 5.8 millimeters in size. MC is usually confined within the mucosa but occasional CIAM cases with MC extending to the submucosa have been reported. MC of CIAM demonstrates bland cytology and inconspicuous proliferative activity. The lesional cells are positive for synaptophysin and 60% to 100% of cases show nuclear β-catenin positivity. MC poses a diagnostic challenge with its morphologic and immunohistochemical resemblance to both benign and malignant lesions, including squamous morules/metaplasia, adenocarcinoma, squamous cell carcinoma, sporadic neuroendocrine tumor and goblet cell adenocarcinoma. CIAM is an indolent lesion with a favorable outcome. Complete removal by polypectomy is considered curative. Awareness and recognition of this rare entity will help arrive at correct diagnosis and improve patient care. Currently, CIAM is not recognized as a subtype of mixed neuroendocrine-non-neuroendocrine neoplasm by WHO.

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Section: Differential Diagnosismentioning

confidence: 99%

Composite intestinal adenoma-microcarcinoid: An update and literature review

Fu¹,

Kmeid²,

Aldyab³

et al. 2021

WJGE

View full text Add to dashboard Cite

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Management of Appendix Neuroendocrine Neoplasms: Insights on the Current Guidelines

Mohamed

Hamid

et al. 2022

Cancers

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Appendiceal neuroendocrine neoplasms (ANENs) usually present as incidental findings at the time of appendectomy for acute appendicitis. They are rare, accounting for only 0.5–1% of intestinal neoplasms; they are found in 0.3–0.9% of all appendectomy specimens. They are usually sporadic tumors. There are several histological types including well-differentiated neuroendocrine tumors (NETs), poorly differentiated neuroendocrine carcinomas (NECs), and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs). Histologic differentiation and the grade of well-differentiated NETs correlate with clinical behavior and prognosis. Management varies based on differentiation, aggressiveness, and metastatic potential. There is debate about the optimal surgical management for localized appendiceal NETs that are impacted by many factors including the tumor size, the extent of mesoappendiceal spread, lymphovascular invasion and perineural involvement. In addition, the data to guide therapy in metastatic disease are limited due to the paucity of these tumors. Here, we review the current advances in the management of ANENs within the context of a multidisciplinary approach to these tumors.

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Goblet cell carcinoid of the appendix accompanied by adenomatous polyp with high-grade dysplasia at the cecum

Cited by 2 publications

References 20 publications

Composite intestinal adenoma-microcarcinoid: An update and literature review

Composite intestinal adenoma-microcarcinoid: An update and literature review

Management of Appendix Neuroendocrine Neoplasms: Insights on the Current Guidelines

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