“…The UWF FA revealed peripheral vascular abnormalities (ie, microaneurysms, vascular leakage) in six patients; however, these features have been extensively documented as paraphysiologic changes in healthy subjects. 24,25 One patient presented subretinal hyperreflectivity in both eyes; we can speculate it was related to the accumulation of lipofuscin at the level of the RPE, such as an acquired vitelliform lesion. 26 However, acquired vitelliform lesions has been associated with a variety of retinal conditions, like retinal dystrophies, reticular pseudodrusen, cuticular drusen, pseudoxanthoma elasticum, central serous chorioretinopathy, macular telangiectasia type 2, RPE detachment, vitreomacular interface disease, immunogammapathies, drug toxicity, and paraneoplastic syndromes.…”