Appearance of Far Peripheral Retina in Normal Eyes by Ultra-widefield Fluorescein Angiography

Lü, Jing; Mai, Guiying; Luo, Yan; Mei, Li; Cao, Di; Wang, Xiao; Hong, Ying; Sadda, Srinivas R.; Lü, Lin

doi:10.1016/j.ajo.2016.09.024

Cited by 32 publications

(32 citation statements)

References 19 publications

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“…The UWF FA revealed peripheral vascular abnormalities (ie, microaneurysms, vascular leakage) in six patients; however, these features have been extensively documented as paraphysiologic changes in healthy subjects. 24,25 One patient presented subretinal hyperreflectivity in both eyes; we can speculate it was related to the accumulation of lipofuscin at the level of the RPE, such as an acquired vitelliform lesion. 26 However, acquired vitelliform lesions has been associated with a variety of retinal conditions, like retinal dystrophies, reticular pseudodrusen, cuticular drusen, pseudoxanthoma elasticum, central serous chorioretinopathy, macular telangiectasia type 2, RPE detachment, vitreomacular interface disease, immunogammapathies, drug toxicity, and paraneoplastic syndromes.…”

Section: Abnormal 11mentioning

confidence: 97%

<p>Multimodal Chorioretinal Imaging in Erdheim-Chester Disease</p>

Sacconi¹,

Campochiaro²,

Rabiolo³

et al. 2020

OPTH

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To analyze the subclinical intraocular involvement using multimodal imaging approach in patients affected by Erdheim-Chester disease (ECD) without ocular symptoms. Patients and Methods: In this prospective cross-sectional study, 18 eyes of 9 consecutive patients with ECD were enrolled. Each patient underwent comprehensive ocular examination and extensive multimodal chorioretinal imaging. Results: None of the patients presented any evidence of chorioretinal localization of disease using multimodal imaging. One patient exhibited a choroidal nevus complicated by active polypoidal choroidal neovascularization. Subretinal hyperreflective material was seen in three eyes, mainly resembling acquired vitelliform lesion. One patient had an isolated intraretinal hemorrhage. Most patients exhibited peripheral vascular abnormalities (ie, microaneurysms, peripheral vascular leakage). Fundus autofluorescence showed faint hyperautofluorescence in eleven eyes. Conclusion: Intraocular involvement is an extremely rare event of an extremely rare disease. In patients affected by ECD without ocular symptoms, advance multimodal imaging examinations did not show signs of subclinical chorioretinal involvement related to the disease.

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Section: Abnormal 11mentioning

confidence: 97%

<p>Multimodal Chorioretinal Imaging in Erdheim-Chester Disease</p>

Sacconi¹,

Campochiaro²,

Rabiolo³

et al. 2020

OPTH

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“…In order to evaluate the pathological angiography findings in various diseases, first of all, it is necessary to evaluate the normal retinal findings in wide-field angiography. [23,24] Perfused vascular border distance decreases after 60 years of age in all quadrants [24]. Normal peripheral retinas infrequently show granular background fluorescence [23].…”

Section: Applications Of Wide-field Imaging In Clinical Practice 71 mentioning

confidence: 99%

“…[23,24] Perfused vascular border distance decreases after 60 years of age in all quadrants [24]. Normal peripheral retinas infrequently show granular background fluorescence [23]. Figure 4 shows wide-field images of healthy eyes.…”

Section: Applications Of Wide-field Imaging In Clinical Practice 71 mentioning

confidence: 99%

Wide-Field Retinal Imaging in Adults and Children

Bilgeç¹,

Erol²,

Topbaş³

2019

Novel Diagnostic Methods in Ophthalmology

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Wide-field retinal imaging has become an important standard of care imaging modality in many retinal disorders both in adults and children. The recently developed wide-field retinal imaging systems enable approximately 200° imaging of retina. In this chapter, we would like to review the use of wide-field retinal imaging in disorders such as retinal vascular diseases, uveal and retinal inflammatory diseases, intraocular tumors, peripheral retinal pathologies, and retinal disorders in children such as retinopathy of prematurity, familial exudative vitreoretinopathy, and Coats' disease. Also, we would like to address the rapidly expanding role of peripheral retinal imaging in treating systemic diseases. The use of wide-field imaging technologies in screening, diagnosis, treatment, and documentation of retinal pathologies and the new information provided by wide-field angiography for retinal vascular diseases and macular problems will be discussed.

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“…Lu et al fanden in allen gesunden, mit der Weitwinkel-FAG untersuchten Augen eine granuläre Hyperfluoreszenz an eben dieser Orakante. Dies scheint somit ein normales physiologisches Zeichen im Sinne eines Fensterdefekts zu sein, was erneut auf die dünnere Netzhautschicht, die abnehmende Dichte der RPE-Zellen und bessere Sichtbarkeit der Bruchʼschen Membran und Chorioidea zurückzuführen ist [20,21].…”

Section: Fluoreszenzangiografie (Fag)unclassified

“…Die gemessene periphere Leckage, die bei knapp 20 % der Augen auftrat, wurde als inflammatorisches Zeichen einer subklinischen Uveitis intermedia gewertet, da bei diesen Patienten auch gehäuft Floater und eine im UBM (Ultraschallbiomikroskopie) gemessene Ziliarkörperschwellung gefunden wurden [20].…”

Section: Fluoreszenzangiografie (Fag)unclassified

Peripher exsudative hämorrhagische Chorioretinopathie: Krankheitsverlauf, Diagnosestellung inklusive Weitwinkelbildgebung der assoziierten Erkrankungen altersabhängige Makuladegeneration und polypoidale Choriovaskulopathie, Therapie

Seibel

Nürnberg

Löwen

et al. 2018

Klin Monatsbl Augenheilkd

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PEHCR (peripheral exudative haemorrhagic chorioretinopathy) is a disease manifested clinically, particularly by subretinal bleeding, retinal exudates, retinal pigment epithelium detachments (RPE detachments), exudative retinal detachment and sub-RPE bleeding. The PEHCR lesion is often characterized by its polypoidal pattern, which is very similar to PCV (polypoidal choroidal vasculopathy) polyps. Diagnosis is best made with a wide-field ICGA (indocyanine green angiography). In approximately half of patients, macular changes in the form of drusen, up to exudative AMD (age-related macular degeneration), are detected in the affected eye or partner eye. Since there is very little literature directly available on PEHCR, this work also discusses the peripheral changes described in the context of AMD that were investigated with wide-field imaging.

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Appearance of Far Peripheral Retina in Normal Eyes by Ultra-widefield Fluorescein Angiography

Cited by 32 publications

References 19 publications

<p>Multimodal Chorioretinal Imaging in Erdheim-Chester Disease</p>

<p>Multimodal Chorioretinal Imaging in Erdheim-Chester Disease</p>

Wide-Field Retinal Imaging in Adults and Children

Peripher exsudative hämorrhagische Chorioretinopathie: Krankheitsverlauf, Diagnosestellung inklusive Weitwinkelbildgebung der assoziierten Erkrankungen altersabhängige Makuladegeneration und polypoidale Choriovaskulopathie, Therapie

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