Aporphine alkaloids of Litsea sebifera, L. wightiana and Actinodaphne obovata

Uprety, Hema; Bhakuni, D. S.; Dhar, Mridul

doi:10.1016/0031-9422(72)80105-5

Cited by 24 publications

(27 citation statements)

References 6 publications

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“…In summary, we have observed that Actinodaphne pruinosa produces alkaloids closely related to those found in A. nitida, A. acutivena, A. abovata and A. sesquipedalis which were studied previously [4,9,10]. These species yielded noraporphine or N -methylaporphine types.…”

Section: Discussionsupporting

confidence: 58%

“…The IR spectrum revealed an absorption band at 3,180 cm -1 due to the OH stretching vibration. The overall physical properties and NMR spectral profile revealed its identity as a member of the aporphine group of isoquinoline, a characteristic and distinguishable chemical marker of Actinodaphne plants [3,4]. …”

Section: Resultsmentioning

confidence: 99%

“…Locally, Actinodapne is known as wuru (Indonesia) or medang kuning and medang kunyit (Malaysia) [1,2]. Actinodaphne plants of the family Lauraceae have been reported to produce isoquinoline alkaloids (aporphines, oxoaporphines) and lactones [3,4]. These alkaloids are of some pharmacological importance, as exemplified by liriodenine, an oxoaporphine, which was reported to have antitumor, antibacterial, and antifungal activities [5].…”

Section: Introductionmentioning

confidence: 99%

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(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

et al. 2009

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One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.

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Section: Discussionsupporting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

et al. 2009

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“…In a previous communication, we reported two new aporphine alkaloids, cathafiline (1) and cathaformine (2), along with six known compounds, actinodaphnine (3), cassythine, isoboldine, cassameridine, cassamedine, and lysicamine, from the fresh herbs of Formosan grown Cassytha filiformis. (Lauraceae) was found to exhibit significant vasorelaxant activity as well as inhibitory effects on the platelet aggregation induced by several aggregating agents.…”

mentioning

confidence: 99%

Chemical Constituents from Cassytha filiformis II

et al. 1998

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Using a bioassay-directed fractionation method, three new compounds, including an aporphine alkaloid, cassyformine (4); an oxoaporphine alkaloid, filiformine (8), and a lignan, (+)-diasyringaresinol (10), along with 14 known compounds, were further isolated and characterized from the MeOH extract of the fresh herbs of Cassytha filiformis. Among the isolates of this plant, cathafiline (1), cathaformine (2), actinodaphnine (3), N-methylactinodaphnine (5), predicentrine (6), and ocoteine (7) exhibited significant antiplatelet aggregation activity.

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“…The root of A. lancifolia is a traditional Chinese medicine used for the treatment of stomachache, arthritis, overexertion, and edema (4). This genus have been reported to produce isoquinoline alkaloids (5), lactones (6), lignans (7), and phenolic amides (8). From the literature survey, Actinodaphne species have been reported to have antimicrobial (9), hepatoprotective (10), anti-inflammatory (11), antibacterial (12) and antioxidant (13) activities.…”

Section: Introductionmentioning

confidence: 99%

Preliminary investigations of antioxidant, antityrosinase, acetylcholinesterase and anti-inflammatory activities of Actinodaphne species

Salleh

Ahmad

2016

Marmara Pharm J

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The purpose of this study was to investigate the biological activities of extracts from two Actinodaphne species from Malaysia, which are Actinodaphne macrophylla and Actinodaphne pruinosa. The in vitro activity studies were assessed for their antioxidant, antityrosinase, acetylcholinesterase and anti-inflammatory activities. The methanolic bark extract of A. pruinosa have shown the highest activity on DPPH • (IC 50 : 70.2 μg/mL), ABTS •+ (IC 50 : 147.2 μg/mL) and phenolic content (55.1 mg gallic acid/g), while the bark extracts of A. macrophylla showed the best inhibitory activity against mushroom tyrosinase (I: 45.2%) and lipoxygenase (I: 69.2%) assays. All extracts have shown strong AChE inhibitory activity (I: 70.5-88.1%), comparable to galantamine (I: 95.9%). The isolation of specific bioactive compounds as well as evaluating their safety may be necessary in the exploration of these species for potential new therapeutic drugs or drug leads.

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Aporphine alkaloids of Litsea sebifera, L. wightiana and Actinodaphne obovata

Cited by 24 publications

References 6 publications

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

Chemical Constituents from Cassytha filiformis II

Preliminary investigations of antioxidant, antityrosinase, acetylcholinesterase and anti-inflammatory activities of Actinodaphne species

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