Apoptotic Effect and Anticancer Activity of Biosynthesized Silver Nanoparticles from Marine Algae Chaetomorpha linum Extract Against Human Colon Cancer Cell HCT-116

Acharya, Diptikanta; Satapathy, Sagarika; Somu, Prathap; Parida, Umesh Kumar; Mishra, Gayatri

doi:10.1007/s12011-020-02304-7

Cited by 92 publications

(27 citation statements)

References 41 publications

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“…The production of melatonin is a two-way method, so if the melatonin production is blocked in mitochondria it will start in chloroplasts. In plants it is produced by a specific enzyme M3H [19].…”

Section: Production Of Melatonin In Plantsmentioning

confidence: 99%

Melatonin as Master Regulator in Plant Growth, Development and Stress Alleviator for Sustainable Agricultural Production: Current Status and Future Perspectives

et al. 2020

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Melatonin, a multifunctional signaling molecule, is ubiquitously distributed in different parts of a plant and responsible for stimulating several physiochemical responses against adverse environmental conditions in various plant systems. Melatonin acts as an indoleamine neurotransmitter and is primarily considered as an antioxidant agent that can control reactive oxygen and nitrogen species in plants. Melatonin, being a signaling agent, induces several specific physiological responses in plants that might serve to enhance photosynthesis, growth, carbon fixation, rooting, seed germination and defense against several biotic and abiotic stressors. It also works as an important modulator of gene expression related to plant hormones such as in the metabolism of indole-3-acetic acid, cytokinin, ethylene, gibberellin and auxin carrier proteins. Additionally, the regulation of stress-specific genes and the activation of pathogenesis-related protein and antioxidant enzyme genes under stress conditions make it a more versatile molecule. Because of the diversity of action of melatonin, its role in plant growth, development, behavior and regulation of gene expression it is a plant’s master regulator. This review outlines the main functions of melatonin in the physiology, growth, development and regulation of higher plants. Its role as anti-stressor agent against various abiotic stressors, such as drought, salinity, temperatures, UV radiation and toxic chemicals, is also analyzed critically. Additionally, we have also identified many new aspects where melatonin may have possible roles in plants, for example, its function in improving the storage life and quality of fruits and vegetables, which can be useful in enhancing the environmentally friendly crop production and ensuring food safety.

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Section: Production Of Melatonin In Plantsmentioning

confidence: 99%

Melatonin as Master Regulator in Plant Growth, Development and Stress Alleviator for Sustainable Agricultural Production: Current Status and Future Perspectives

et al. 2020

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“…The described Ag NPs mechanisms of action are visually represented in Figure 3; similar paths have also been proposed for other noble metal-based nanoparticles, including Au NPs [13,46], platinum NPs [47], and palladium NPs [48]. Significant results concerning Ag NPs antitumor activity were reported against several human cancer cell lines [43] (Table 1), including hepatocellular carcinoma [51][52][53], breast cancer [54][55][56][57], ovarian cancer [58,59], prostate cancer [60][61][62], colon cancer [30,[63][64][65][66], lung cancer [58,60,67,68], and osteosarcoma [69,70].…”

Section: Silver Npsmentioning

confidence: 56%

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

et al. 2022

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Cancer continues to represent a global health concern, imposing an ongoing need to research for better treatment alternatives. In this context, nanomedicine seems to be the solution to existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered the advantageous properties of various nanoscale metals, this review aims to present metal-based nanoparticles that are most frequently employed for cancer applications. This paper follows the description of relevant nanoparticles made of metals, metal derivatives, hybrids, and alloys, further discussing in more detail their potential applications in cancer management, ranging from the delivery of chemotherapeutics, vaccines, and genes to ablative hyperthermia therapies and theranostic platforms.

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“…В данном способе водный экстракт водорослей выступает в качестве восстановителя и стабилизирующего агента, что упрощает методику получения и делает ее экологически безопасной и экономически выгодной. Комплексом методов, таких как проточная цитофлуориметрия, анализ митохондриальной дисфункции, анализ экспрессии белков, обработанных наночастицами, была показана высокая цитотоксическая активность [17]. Данная работа демонстрирует возможность применения наночастиц серебра в качестве альтернативного метода лечения опухолевых заболеваний толстой кишки, так как жизнедеятельность клеток HCT-116 подавляется обработкой C-AgNP в концентрации 48,84 и 32,75 мкг/мл в течение периода лечения 24 и 48 часов соответственно.…”

Section: наночастицы серебра для противораковой терапииunclassified

Biomedical Applications of Silver Nanoparticles (Review)

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et al. 2021

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Silver nanoparticles have unique physicochemical properties and can be used for the diagnosis and treatment of various kinds of infections, oncological diseases, as well as drug delivery. The review presents an analysis of scientific literature on the use of silver nanoparticles for biomedical purposes.Text. The review discusses the perspectives of the silver nanoparticles use in the treatment of oncological diseases as a carrier of drugs, as well as the direct manifestation of their cytotoxic effect on cancer cells. Also, there is considered the use of silver nanoparticles for imparting or enhancing the antibacterial effects of dressings and dental materials. The mechanism of action of silver nanoparticles against viruses is considered. This research presents the use of composite materials containing silver nanoparticles for biomedical purposes.Conclusion. On the basis of the literature data analysis, carried out by the authors, there are shown possibilities of the nanotechnology achievements for the application in medicine.

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Apoptotic Effect and Anticancer Activity of Biosynthesized Silver Nanoparticles from Marine Algae Chaetomorpha linum Extract Against Human Colon Cancer Cell HCT-116

Cited by 92 publications

References 41 publications

Melatonin as Master Regulator in Plant Growth, Development and Stress Alleviator for Sustainable Agricultural Production: Current Status and Future Perspectives

Melatonin as Master Regulator in Plant Growth, Development and Stress Alleviator for Sustainable Agricultural Production: Current Status and Future Perspectives

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

Biomedical Applications of Silver Nanoparticles (Review)

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