Apoptosis-targeting therapies

Melnikova, Irena; Golden, James

doi:10.1038/nrd1554

Cited by 19 publications

(9 citation statements)

References 3 publications

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“…Moreover, VS enables diverse compounds that would seldom be tested in a traditional laboratory high-throughput screen to be identified. The number of success stories from using VS in drug discovery keeps growing (69,80). Recently we applied this docking strategy to the APE/Ref-1 receptor by screening chemical libraries (Fig.…”

Section: Novel Strategies Targeting Ape/ref-1 To Prevent/treat Human mentioning

confidence: 99%

Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma

Yang

Meyskens

2009

Antioxidants & Redox Signaling

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Management of melanoma is a growing and challenging public health issue requiring novel and multidisciplinary approaches to achieve more efficient prevention and therapeutic benefits. The aim of this article is to show the critical role of APE/Ref-1 on melanomagenesis and progression. APE/Ref-1 serves as a redox-sensitive node of convergence of various signals as well as a DNA-repair enzyme, and its activation protects melanocytes and melanoma cells from chronic oxidative stress and promotes cell survival via mediation of downstream pathways. APE/Ref-1 is a strong candidate as a potential drug-treatable target for the prevention and treatment of human melanoma. Lead compounds exhibiting inhibitory effects on APE/Ref-1 are also reviewed. We anticipate potential clinical benefit in the future through inhibition of APE/Ref-1 and/or Ref-1-mediated signaling.

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Section: Novel Strategies Targeting Ape/ref-1 To Prevent/treat Human mentioning

confidence: 99%

Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma

Yang

Meyskens

2009

Antioxidants & Redox Signaling

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“…A sort of programmed cell death known as apoptosis, which happens in multicellular organisms, was a tightly controlled and regulated process that offers benefits throughout an organism’s life cycle [ 44 , 45 ]. A previous study showed that Caspase-3 , one of the most typical factors of apoptosis, was significantly increased in Huh7 cells cultured with VIP [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Vasoactive Intestinal Peptide (VIP) Protects Nile Tilapia (Oreochromis niloticus) against Streptococcus agalatiae Infection

Zhang

Huang

et al. 2022

IJMS

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Vasoactive intestinal peptide (VIP), a member of secretin/glucagon family, is involved in a variety of biological activities such as gut motility, immune responses, and carcinogenesis. In this study, the VIP precursor gene (On-VIP) and its receptor gene VIPR1 (On-VIPR1) were identified from Nile tilapia (Oreochromis niloticus), and the functions of On-VIP in the immunomodulation of Nile tilapia against bacterial infection were investigated and characterized. On-VIP and On-VIPR1 contain a 450 bp and a 1326 bp open reading frame encoding deduced protein of 149 and 441 amino acids, respectively. Simultaneously, the transcript of both On-VIP and On-VIPR1 were highly expressed in the intestine and sharply induced by Streptococcus agalatiae. Moreover, the positive signals of On-VIP and On-VIPR1 were detected in the longitudinal muscle layer and mucosal epithelium of intestine, respectively. Furthermore, both in vitro and in vivo experiments indicated several immune functions of On-VIP, including reduction of P65, P38, MyD88, STAT3, and AP1, upregulation of CREB and CBP, and suppression of inflammation. Additionally, in vivo experiments proved that On-VIP could protect Nile tilapia from bacterial infection and promote apoptosis and pyroptosis. These data lay a theoretical basis for further understanding of the mechanism of VIP guarding bony fish against bacterial infection.

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“…Further studies showed that obatoclax is a pan-Bcl-2 inhibitor that blocks BH3-mediated binding of Bax and Bak to their binding partners (Bcl-2, Bcl-xl, Mcl-1, and A1), thereby resulting in pro-apoptotic activity. 184 One of them is oblimersen sodium (Genasense ® ), an 18-mer oligonucleotide that was the first agent targeting the Bcl-2 pathway to enter clinical trials. 180 HA14-1 decreases Bcl-2 and Bcl-xl expression and increases the expression of p53, suggesting that this compound may provide therapeutic potential for the treatment of human cervical cancer.…”

Section: Drugs Targeting the Bcl-2 Family Of Proteins: Bh3 Mimeticsmentioning

confidence: 99%

Other Nonbiological Approaches to Targeted Cancer Chemotherapy

Avendaño

Menéndez

2015

Medicinal Chemistry of Anticancer Drugs

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Apoptosis-targeting therapies

Cited by 19 publications

References 3 publications

Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma

Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma

Vasoactive Intestinal Peptide (VIP) Protects Nile Tilapia (Oreochromis niloticus) against Streptococcus agalatiae Infection

Other Nonbiological Approaches to Targeted Cancer Chemotherapy

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