Apoptosis inhibition effect of Dihydromyricetin against UVA-exposed human keratinocyte cell line

He, Zhe; Zhang, Li; Zhuo, Cuiqin; Jin, Fujun; Wang, Yifei

doi:10.1016/j.jphotobiol.2016.05.002

Cited by 22 publications

(8 citation statements)

References 36 publications

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“…Some previous studies about the molecular mechanisms underlying DHM‐mediated pharmacological effects had already confirmed several signaling pathways that were identified in our present study. For example, DHM has been reported to exert the role of anti‐tumor activity by regulating the p53 pathway (KEGG ID: 04115), NF‐κB pathway (KEGG ID: 04064), and mTOR pathway (KEGG ID: 04150) in human hepatocellular, ovarian, and gastric cancer cells; neuroprotective activity by regulating the PI3K‐Akt pathway (KEGG ID: 04151) and mTOR pathway; anti‐inflammatory activity by regulating NF‐κB pathway and MAPK pathway (KEGG ID: 04010); and other pharmacological activities such as cardioprotective effect by regulating HIF‐1 signaling pathway (KEGG ID: 04066) and PI3K‐Akt pathway (KEGG ID: 04151) . These data provide preliminary evidence for the validation of predicted molecular targets of DHM using a bioinformatics approach.…”

Section: Resultsmentioning

confidence: 99%

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Wang

Xiao

Yang

et al. 2018

Journal of Leukocyte Biology

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Dihydromyricetin (DHM), a bioactive flavonoid component isolated from Ampelopsis grossedentata, is known to have anti-inflammatory effect, but the effect of DHM on acute lung injury (ALI) is largely unknown. Here, we investigated the effect of DHM on ALI and the underlying mechanism by bioinformatic analyses and animal experiments. We found that pretreatment with DHM ameliorated lung pathological changes and suppressed the inflammation response in lung tissues after LPS challenge. The potential targets of DHM were predicted by DDI-CPI and DRAR-CPI tools and analyzed using the STRING server to predict the functionally related signaling pathways, such as MAPK signaling. Molecular docking calculations indicated that DHM could be embedded tightly into the binding pocket of ERK, JNK, and p38. Furthermore, the activation of MAPK signaling induced by LPS was inhibited by DHM. In conclusion, these findings suggest that DHM may exert its protective effect on ALI by inhibiting MAPK signaling. The present study supports a potential clinical application for DHM in treating ALI and provides a novel design that combines in silico methods with in vivo experiments for drug research.

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Section: Resultsmentioning

confidence: 99%

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Wang

Xiao

Yang

et al. 2018

Journal of Leukocyte Biology

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“…Additionally, DHM treatment also prevented the nuclear translocation of NF-κB/p65 and phosphorylation of c-Jun (ref. 146 ).…”

Section: Dihydromyricetinmentioning

confidence: 99%

Ultraviolet A protective potential of plant extracts and phytochemicals

2020

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Chronic exposure to solar radiation is related to an increased incidence of various skin disorders, including premature skin aging and melanoma and non-melanoma skin cancers. Ultraviolet (UV) photons in particular are responsible for skin damage. Solar UV photons mainly belong to UVA wavebands, however UVA radiation has been mostly ignored for a long time. At the cellular level, UVA photons mainly provoke indirect oxidative damage to biomolecules via the massive generation of unstable and highly reactive compounds. Human skin has several effective mechanisms that forestall, repair and eliminate damage caused by solar radiation. Regardless, some damage persists and can accumulate with chronic exposure. Therefore, conscious protection against solar radiation (UVB+UVA) is necessary. Besides traditional types of photoprotection such as sunscreen use, new strategies are being searched for and developed. One very popular protective strategy is the application of phytochemicals as active ingredients of photoprotection preparations instead of synthetic chemicals. Phytochemicals usually possess additional biological activities besides absorbing the energy of photons, and those properties (e.g. antioxidant, anti-inflammatory) magnify the protective potential of phytochemicals and extracts. Therefore, compounds of natural origin are in the interest of researchers as well as developers. In this review, only studies on UVA protection with well-documented experimental conditions are summarized. This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals.

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“…DMY increased mitochondrial membrane potential, Bcl-2 and Bcl-xl expression while decreased Bax level and caspase activation. Moreover, DMY blocked NF-κB/p65 translocation into nucleus and inhibited JNK phosphorylation ( He et al, 2016 ). Therefore, DHM may be potentially developed to protect against UVA-induced skin damage.…”

Section: Dermatoprotectionmentioning

confidence: 99%

Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin

et al. 2018

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As the most abundant natural flavonoid in rattan tea, dihydromyricetin (DMY) has shown a wide range of pharmacological effects. In addition to the general characteristics of flavonoids, DMY has the effects of cardioprotection, anti-diabetes, hepatoprotection, neuroprotection, anti-tumor, and dermatoprotection. DMY was also applied for the treatment of bacterial infection, osteoporosis, asthma, kidney injury, nephrotoxicity and so on. These effects to some extent enrich the understanding about the role of DMY in disease prevention and therapy. However, to date, we still have no outlined knowledge about the detailed mechanism of DMY, which might be related to anti-oxidation and anti-inflammation. And the detailed mechanisms may be associated with several different molecules involved in cellular apoptosis, oxidative stress, and inflammation, such as AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), protein kinase B (Akt), nuclear factor-κB (NF-κB), nuclear factor E2-related factor 2 (Nrf2), ATP-binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-γ (PPARγ) and so on. Here, we summarized the current pharmacological developments of DMY as well as possible mechanisms, aiming to push the understanding about the protective role of DMY as well as its preclinical assessment of novel application.

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Apoptosis inhibition effect of Dihydromyricetin against UVA-exposed human keratinocyte cell line

Cited by 22 publications

References 36 publications

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Ultraviolet A protective potential of plant extracts and phytochemicals

Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin

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