Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum

Hiroshima, Kenzo; Toyozaki, Tetsuya; Iyoda, Akira; Yusa, Toshikazu; Fujisawa, Takehiko; Ohwada, Hayato

doi:10.1002/1097-0142(20011001)92:7<1798::aid-cncr1696>3.0.co;2-v

Cited by 16 publications

(15 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The originating stem cells may be more primitive than previously thought. This is consistent with the formation of teratomas in the adult [24,25,35,47,48,52]. These tumors must arise from a primitive stem cell with differentiation potential across all three dermal lineages.…”

Section: Discussionsupporting

confidence: 79%

Osteosarcoma Cells Differentiate into Phenotypes from all Three Dermal Layers

Russinoff

Miran

Gowda

et al. 2011

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 79%

Osteosarcoma Cells Differentiate into Phenotypes from all Three Dermal Layers

Russinoff

Miran

Gowda

et al. 2011

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…A decrease in apoptosis occurs during progression from adenoma to carcinoma in the colorectum (21,22) and during progression from intraepithelial neoplasia to carcinoma in the prostate (24). We have previously reported that immature teratomas exhibited higher proliferative activity but lower rates of apoptosis than mature teratomas (20).…”

Section: Discussionmentioning

confidence: 88%

“…The TUNEL assay was performed as described elsewhere (20). The apoptotic index (AI) was defined as the sum of the number of apoptotic cells and apoptotic bodies divided by the total number of tumor cells.…”

Section: '-End Labeling Of Dna In Apoptotic Cellsmentioning

confidence: 99%

Proliferative Activity and Apoptosis in Thymic Epithelial Neoplasms

et al. 2002

Self Cite

View full text Add to dashboard Cite

The classification of thymic epithelial tumors is controversial because prediction of the biological behavior of these tumors from their morphologic appearance is difficult. The aim of this study was to evaluate the proliferative activity and rate of apoptosis of thymic epithelial tumors classified according to World Health Organization histological classification. We also attempted to determine the importance of a number of proapoptotic factors in these processes. We investigated 46 surgically resected thymic epithelial tumors (8 Type A, 8 Type AB, 7 Type B1, 7 Type B2, 6 Type B3, and 10 Type C). Immunohistochemical staining was performed to determine the tumor expression of p53 protein, Bax, Bcl-2, and survivin. In addition, the Ki-67 labeling index (LI) and apoptotic index (AI) of these tumors were evaluated. Type C thymoma had a higher LI (16.55 ؎ 12.12%) than did the other histological subtypes. Stage IV thymoma (12.36 ؎ 9.99%) had a higher LI than did Stage I tumor. The AI was significantly elevated in Type B1 thymoma (1.47 ؎ 0.55%). Overexpression of p53 protein was observed in Type B3 and C thymomas. p53 proteinpositive tumors had a higher LI than did p53 protein-negative tumors (P < .0001). Bcl-2 expression was observed in Type A, AB, and C thymomas. Bcl-2-positive thymoma had a lower AI than did Bcl-2-negative thymoma (P ‫؍‬ .0157). These results suggest that overexpression of p53 protein is associated with a higher tumor proliferative activity and that Bcl-2 acts as an inhibitor of apoptosis in thymoma.Bcl-2 and p53 protein expression may be useful markers in differentiating thymoma subtypes.

show abstract

“…4 It has been reported that in patients younger than 15 years of age immature mediastinal teratomas behave similarly to mature teratoma like mass lesions, whereas in those older than 15 years these tumors pursue a malignant course. 2 More recently, Hiroshima et al 8 suggested that the prognosis for patients with immature teratoma older than 15 years is as good as the prognosis for patients with mature teratoma if the patient has complete tumor resection after receiving chemotherapy.…”

Section: Commentmentioning

confidence: 99%