2007
DOI: 10.1590/s0100-879x2007001100002
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Abstract: Apolipoprotein E (ApoE) is one of the most extensively studied genes in the context of aging, but there are few population-based studies on ApoE polymorphism in the elderly in developing countries. The objective of the present study was to assess ApoE allele and genotype distribution in a large elderly community-based sample and its association with age, sex and skin color. Participants included 1408 subjects (80.8% of all residents aged ≥60 years) residing in Bambuí city, MG, Brazil. The DNA samples were subj… Show more

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Cited by 20 publications
(14 citation statements)
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“…The mean age of the cohort participants was 69.3 years (range: 60-95 years), and 60.0% were women. White skin color was predominant (60.4%), followed by light brown ("moreno", 33.3%), dark brown ("mulato", 3.6%), and black (2.7%) (22). The prevalence of hypertension (61.5%) was close to that described for the North American elderly (~60%) (23), as well as the prevalence of some traditional risk factors (24).…”
Section: The Bambuí Health Ageing Study (Bhas)mentioning
confidence: 62%
“…The mean age of the cohort participants was 69.3 years (range: 60-95 years), and 60.0% were women. White skin color was predominant (60.4%), followed by light brown ("moreno", 33.3%), dark brown ("mulato", 3.6%), and black (2.7%) (22). The prevalence of hypertension (61.5%) was close to that described for the North American elderly (~60%) (23), as well as the prevalence of some traditional risk factors (24).…”
Section: The Bambuí Health Ageing Study (Bhas)mentioning
confidence: 62%
“…However, due to the extreme differences in the frequency of apo E isoforms e apo E2 is present in only 5% of the population whereas apo E3 is 80% frequent -requires specific protocols to evaluate this influence [34].…”
Section: Discussionmentioning
confidence: 99%
“…Among the elderly who had blood samples taken, 1,408 were genotyped for apoE polymorphism; allele frequencies (ε3: 80.0%; ε4: 13.5%; ε2: 6.5%) were within the Hardy-Weinberg equilibrium expectations 31 . The ε3ε3 genotype was the most commonly observed (63.3%), followed by ε3ε4 (22%), ε2ε3 (11.4%), ε4ε4 (1.8%), ε2ε4 (1.4%) and ε2ε2 (0.1%).…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, the participants were classified as ε4 carriers or non-ε4 carriers. Individuals with the ε2ε4 genotype (1,4%) were excluded from all analyses because of the opposing effects of these two alleles on health status 31 .…”
Section: Discussionmentioning
confidence: 99%