Apolipoprotein D gene expression in the rat brain and light and electron microscopic immunocytochemistry of apolipoprotein D expression in the cerebellum of neonatal, immature and adult rats

Ong, Wei Yi; Lau, Chi-Ieong; Leong, Siew Meng; Kumar, Ujendra; Suresh, Sundar; Patel, Seema

doi:10.1016/s0306-4522(98)00507-7

Cited by 39 publications

(32 citation statements)

References 23 publications

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“…Consequently, lipid metabolism involving apoplipoprotein D is postulated to play a role in neuronal repair in response to different stress stimuli. Similar to our observations in mouse brain, electron microscopic immunocytochemical analyses have also demonstrated increased postnatal expression of apolipoprotein D in 10-day-old and 20-day-old rat brain compared to neonatal rat brain (52). Viewed together with our GeneChip expression data, these observations raise the possibility that apolipoprotein D also plays a protective role in neurons in response to viral infection and that the postnatal increase in basal levels of apolipoprotein D expression could contribute to the resistance of older mice to virus-induced injury.…”

Section: Discussionsupporting

confidence: 90%

Age-Dependent Resistance to Lethal Alphavirus Encephalitis in Mice: Analysis of Gene Expression in the Central Nervous System and Identification of a Novel Interferon-Inducible Protective Gene, MouseISG12

Labrada

Liang

Wang

et al. 2002

J Virol

110

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Several different mammalian neurotropic viruses produce an age-dependent encephalitis characterized by more severe disease in younger hosts. To elucidate potential factors that contribute to age-dependent resistance to lethal viral encephalitis, we compared central nervous system (CNS) gene expression in neonatal and weanling mice that were either mock infected or infected intracerebrally with a recombinant strain, dsTE12Q, of the prototype alphavirus Sindbis virus. In 1-day-old mice, infection with dsTE12Q resulted in rapidly fatal disease associated with high CNS viral titers and extensive CNS apoptosis, whereas in 4-week-old mice, dsTE12Q infection resulted in asymptomatic infection with lower CNS virus titers and undetectable CNS apoptosis. GeneChip expression comparisons of mock-infected neonatal and weanling mouse brains revealed developmental regulation of the mRNA expression of numerous genes, including some apoptosis regulatory genes, such as the proapoptotic molecules caspase-3 and TRAF4, which are downregulated during development, and the neuroprotective chemokine, fractalkine, which is upregulated during postnatal development. In parallel with increased neurovirulence and increased viral replication, Sindbis virus infection in 1-day-old mice resulted in both a greater number of host inflammatory genes with altered expression and greater changes in levels of host inflammatory gene expression than infection in 4-week-old mice. Only one inflammatory response gene, an expressed sequence tag similar to human ISG12, increased by a greater magnitude in infected 4-week-old mouse brains than in infected 1-day-old mouse brains. Furthermore, we found that enforced neuronal ISG12 expression results in a significant delay in Sindbis virus-induced death in neonatal mice. Together, our data identify genes that are developmentally regulated in the CNS and genes that are differentially regulated in the brains of different aged mice in response to Sindbis virus infection.

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Section: Discussionsupporting

confidence: 90%

Age-Dependent Resistance to Lethal Alphavirus Encephalitis in Mice: Analysis of Gene Expression in the Central Nervous System and Identification of a Novel Interferon-Inducible Protective Gene, MouseISG12

Labrada

Liang

Wang

et al. 2002

J Virol

110

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“…In normal brain, apolipoprotein D is found primarily in white matter oligodendrocytes (Navarro et al 1998;Ong et al 1999). Finally, in normal younger adults who are continuing to myelinate (Yakovlev and Lecours 1967;Benes et al 1994;Bartzokis et al 2001), brain apolipoprotein D is primarily localized in oligodendrocytes (Schaeren-Wiemers et al 1995;Navarro et al 1998;Kalman et al 2000) as is the case in the rodent CNS where a maturation-associated induction of the gene's expression has been reported (Ong et al 1999).…”

Section: Therapeutic Interventions To Improve Myelinationmentioning

confidence: 94%

Schizophrenia Breakdown in the Well-regulated Lifelong Process of Brain Development and Maturation

Bartzokis

2002

Neuropsychopharmacology

173

133

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“…Apolipoprotein D (ApoD), a member of the lipocalin superfamily of ligand transporters and an apoprotein component of plasma highdensity lipoproteins, has been shown to bind to several small hydrophobic molecules, including cholesterol, progesterone, porphyrins, and arachidonic acid (Ong et al, 1999). Many densely labeled ApoD-immunoreactive cells that had features of OPCs in the immature cerebellum were identified (Ong et al, 1999). In the present study, a threefold increase in ApoD expression was found in OPCs compared with NSCs, confirming the previous findings.…”

Section: Metabolism and Transportersmentioning

confidence: 99%

Differential gene expression in neural stem cells and oligodendrocyte precursor cells: A cDNA microarray analysis

Hu¹,

Fu²,

Zhang³

et al. 2004

J of Neuroscience Research

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The use of neural stem cells (NSCs) or their progeny oligodendrocyte precursor cells (OPCs) represents a promising repair strategy for many neurological disorders. However, the molecular events and biological features during the transition from NSCs to OPCs remain unclear. In the present study, we isolated NSCs from the embryonic rat forebrain and induced them into OPCs by using B104 conditioned medium (B104CM) in vitro. We then employed cDNA array technology to compare changes in gene expression between the two cell populations. Among 1,176 genes examined, 40 were differentially expressed, and some of them may be involved in OPC differentiation from NSCs. Our findings thus provide new insights into the molecular basis of differentiation of OPCs from NSCs.

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Apolipoprotein D gene expression in the rat brain and light and electron microscopic immunocytochemistry of apolipoprotein D expression in the cerebellum of neonatal, immature and adult rats

Cited by 39 publications

References 23 publications

Age-Dependent Resistance to Lethal Alphavirus Encephalitis in Mice: Analysis of Gene Expression in the Central Nervous System and Identification of a Novel Interferon-Inducible Protective Gene, MouseISG12

Age-Dependent Resistance to Lethal Alphavirus Encephalitis in Mice: Analysis of Gene Expression in the Central Nervous System and Identification of a Novel Interferon-Inducible Protective Gene, MouseISG12

Schizophrenia Breakdown in the Well-regulated Lifelong Process of Brain Development and Maturation

Differential gene expression in neural stem cells and oligodendrocyte precursor cells: A cDNA microarray analysis

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