Apneia obstrutiva do sono em portadores da anemia falciforme

Abstract

A Síndrome da Apneia Obstrutiva do Sono (SAOS) é definida como episódios recorrentes de obstrução completa ou parcial das vias aéreas superiores que ocorrem durante o sono. O fluxo aéreo pode estar diminuído ou completamente interrompido, a despeito do esforço inspiratório, resultando em episódios intermitentes de hipoxemia, hipercapnia. A presença de SAOS poderá ser um fator de piora da hipoxemia noturna, da doença de base, concorrendo para ocorrência de síndrome torácica aguda. Com o objetivo de revisar dados sobre a fisiopatologia da SAOS em crianças e adolescentes portadores de anemia falciforme, foi realizada busca eletrônica de artigos no Medline e Lilacs nos últimos dez anos, bem como referências cruzadas dos artigos encontrados. Palavraschaves: "sleep apnea, sickle cell anemia, sickle cell disease, pathophysiology ". Estudos sugerem que a SAOS pode potencializar o quadro clínico, ou seja, as crises álgicas, déficit de estatura, de peso, cognitivo e de inteligência, dessaturação arterial noturna, e acidente vascular cerebral das crianças portadoras de anemia falciforme. Rev. Bras. Hematol. Hemoter. Palavras-chave:Apneia;síndrome da apneia do sono; anemia; anemia falciforme; anemia hemolítica.

Adenotonsillar Hypertrophy in Pre-School Children with Sickle Cell Disease and Diagnostic Accuracy of the Sleep Disturbance Scale for Children

“…In the literature consulted, the prevalence of ATH ranged from 11 to 37.6%, 16 17 which was in line with the findings of our study. Other studies have estimated the prevalence of SDB, whose main cause in children is ATH, 4 14 18 characterized by the occurrence of snoring as an isolated signal (primary snoring), or associated with an increased resistance of the upper airways, with obstructive hypoventilation until the complete collapse, leading to obstructive sleep apnea syndrome. 18 19 While primary snoring affects 9 to 29% of children, SDB with hypoventilation and apnea occurs in 1 to 4% of children.…”

“…Other studies have estimated the prevalence of SDB, whose main cause in children is ATH, 4 14 18 characterized by the occurrence of snoring as an isolated signal (primary snoring), or associated with an increased resistance of the upper airways, with obstructive hypoventilation until the complete collapse, leading to obstructive sleep apnea syndrome. 18 19 While primary snoring affects 9 to 29% of children, SDB with hypoventilation and apnea occurs in 1 to 4% of children. 18 20 Among the other causes of SDB, obesity, craniofacial malformations, neurological diseases, and gastroesophageal reflux disease stand out.…”

“… 18 19 While primary snoring affects 9 to 29% of children, SDB with hypoventilation and apnea occurs in 1 to 4% of children. 18 20 Among the other causes of SDB, obesity, craniofacial malformations, neurological diseases, and gastroesophageal reflux disease stand out. 19 21 22 …”

“…Studies have demonstrated that children with SCD and adenoid vegetations, even with obstruction below 70%, exhibit a higher apnea-hypopnea index than children without SCD. 6 11 18 However, it is possible that this occurs due to other reasons relating to SCD, because obstructive sleep apnea syndrome has a multifactorial etiology. 19 21 22 …”