Sleep disorders and endothelial dysfunction in children with sickle cell anemia

Ramos-Machado, Vinícius; Ladeia, Ana Marice; Teixeira, Rozana dos Santos; Ferreira, Tatiane; Terse-Ramos, Regina

doi:10.1016/j.sleep.2018.08.019

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Ramos‐Machado et al 63 investigated whether the presence of endothelial dysfunction (ED) (evaluated according to the flow‐mediated dilatation using brachial artery ultrasound and the level of cytokines) was related to SDB in a cohort of 60 children with SCD. Patients with SCD and ED showed higher sleep disturbances questionnaire's scores than those without ED but differences were not significant.…”

Section: Resultsmentioning

confidence: 99%

“…A tricuspid regurgitant jet velocity (TRJV) ≥ 2.5 m/s, suggestive of pulmonary hypertension, was present in 5 out 8 SCD patients with nocturnal hypoxemia but only in only 3 out of 15 patients without (p = .005). 17 Ramos-Machado et al 63 investigated whether the presence of endothelial dysfunction (ED) (evaluated according to the flow-mediated dilatation using brachial artery ultrasound and the level of cytokines) was related to SDB in a cohort of 60 children with SCD. Patients with SCD and ED showed higher sleep disturbances questionnaire's scores than those without ED but differences were not significant.…”

Section: Cardiovascular Complicationsmentioning

confidence: 99%

“…Five studies 17,40,[61][62][63] tested the hypothesis that cardiac abnormalities in children with SCD could be related to SDB and nocturnal hypoxemia (Table 5).…”

Section: Cardiovascular Complicationsmentioning

confidence: 99%

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The burden of sleep disordered breathing in children with sickle cell disease

Liguoro

Arigliani

Tan

et al. 2021

Pediatric Pulmonology

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Children with sickle cell disease (SCD) have an increased risk of sleep disordered breathing (SDB) compared with the general pediatric population. There has been a growing research interest on this field in recent years, yet many questions regarding risk factors and clinical implications of SDB remain unclear. The aim of this review is to provide a concise narrative and systematic synthesis of the available evidence on the epidemiology, clinical presentation, complications, and management, of SDB in children with SCD. An electronic search was conducted on studies published from the 1st of January 2000 to the 31st of December 2020 in PubMed/Medline, Scopus, and Cochrane databases. All studies focusing on SDB in children with SCD aged from 0 to 20 years were included. Studies were eligible for inclusion if available in the English language. A quantitative synthesis of the included studies was performed.Only studies focusing on specific treatment outcomes were included in a metaanalytic process. A total of 190 papers were initially identified. After screening the title and abstract, 112 articles were evaluated for eligibility. At the end of the selection process, 62 studies were included in the analysis. Sleep disordered breathing is associated with worse neurological, neurocognitive, and cardiological outcomes, whereas the association with frequency or severity of vaso-occlusive pain events and acute chest syndrome was not clarified. Therapeutic interventions like adenotonsillectomy or oxygen supplementation may result in a significant increase in mean nocturnal oxygen saturation but effective clinical implications remain still unclear.

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Section: Resultsmentioning

confidence: 99%

Section: Cardiovascular Complicationsmentioning

confidence: 99%