Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats

Ren, Bei; Qin, Weiwei; Wu, Feihua; Wang, Shanshan; Pan, Chuyue; Wang, Liying; Zeng, Biao; Ma, Shengming; Liang, Jing‐Yu

doi:10.1016/j.ejphar.2016.01.002

Cited by 173 publications

(113 citation statements)

References 52 publications

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“…The authors suggested that the potent antihyperglycaemic properties observed may be attributed to these components. Flavonoids are known for their high antioxidant power, which has been proposed as a mechanism of action in the treatment of diabetes and its complications . However, further investigation is required to better characterize the active principles …”

Section: Resultsmentioning

confidence: 99%

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Antidiabetic potential ofMusaspp. inflorescence: a systematic review

Vilhena

Fachi

Marson

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives Extracts of parts Musa spp. have been used for the treatment of various diseases in traditional medicine. Studies have shown that these extracts have hypoglycaemic properties. The aim of this work was to gather evidence on the antidiabetic effects of Musa spp. inflorescence. Methods A systematic review was conducted with searches in three electronic databases, along with manual searches. Studies evaluating the antidiabetic properties of extracts of flower or bract of the genus Musa (in vitro or in vivo) were included. Key findings Overall, 16 studies were found. The reported assays were of hypoglycaemic effects, oral glucose tolerance, inhibitory activities in carbohydrate metabolism and digestive enzymes, enhanced glucose uptake activity and popular use of the extract in patients with diabetes type 2. In vitro studies showed that use of the extract was associated with antidiabetic effects (e.g. increased glucose uptake and inhibition of carbohydrate digestion enzymes). In induced diabetic models, Musa spp. extracts showed dose‐dependent glycaemic level reductions compared with pharmacological drugs (P < 0.05). Summary In general, promising results regarding antidiabetic activity were found for inflorescence of Musa spp., suggesting that this plant could represent a natural alternative therapy for treating diabetes mellitus type 2.

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Section: Resultsmentioning

confidence: 99%

“…Flavanones such as naringenin and hesperitin are also present in the flowers of Musa spp . and are known for their high antioxidant power, which has been proposed as a mechanism of action in the treatment of diabetes and its complications …”

Section: Introductionmentioning

confidence: 99%

Antidiabetic potential ofMusaspp. inflorescence: a systematic review

Vilhena

Fachi

Marson

et al. 2018

Journal of Pharmacy and Pharmacology

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“…Studies have shown that kaempferol, apigenin, quercetin, catechin, and luteolin have antioxidant, antidiabetic, hypolipidemic, hypotensive, antibacterial, anti-inflammatory, and anticancer properties (Dillard & German, 2000;Sutherland, Rahman, & Appleton, 2006;Lakhanpal & Rai, 2007;Panda & Kar, 2007;Calderón-Montaño, Burgos-Morón, Pérez-Guerrero, & López-Lázaro, 2011;Ren et al, 2016). Other properties of kaempferol include analgesic, antiallergic, antiprotozoal, antiviral, antifungal, neuroprotective, cardio-protective, and hepatoprotective properties (Calderón-Montaño et al, 2011;Dillard & German, 2000); while those of apigenin are diuretic, hepatoprotective, and cardio-protective properties (Dillard & German, 2000;Panda & Kar, 2007;Ren et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Other properties of kaempferol include analgesic, antiallergic, antiprotozoal, antiviral, antifungal, neuroprotective, cardio-protective, and hepatoprotective properties (Calderón-Montaño et al, 2011;Dillard & German, 2000); while those of apigenin are diuretic, hepatoprotective, and cardio-protective properties (Dillard & German, 2000;Panda & Kar, 2007;Ren et al, 2016). In addition to the above, catechin also have antiviral, antiallergic, antiobesity, antiplatelet, antiulcer, chemo-preventive, neuroprotective, cardio-protective, antispasmodic, bronchodilator, and vasodilator properties (Dillard & German, 2000;Ghayur, Khan, & Gilani, 2007;Sutherland et al, 2006); while quercetin has antiallergic, antiarthritic, anticataractogenic, antiviral, cardioprotective, gastro-protective, and hepatoprotective activities (Dillard & German, 2000;Lakhanpal & Rai, 2007).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Ifeanacho

Ikewuchi

2016

Food Science & Nutrition

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The profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii was investigated using gas chromatography coupled with flame ionization detector. The leaves and stems had high flavonoids and benzoic acid derivatives content, and moderate levels of lignans and hydroxycinnamates. Twenty-eight known flavonoids were detected, which consisted mainly of kaempferol (41.93% in leaves and 47.97% in stems), (+)-catechin (17.12% in leaves and 16.11% in stems), quercetin (13.83% in leaves and 9.39% in stems), luteolin (7.34% in leaves and 7.71% in stems), and artemetin (6.53% in leaves and 4.83% in stems). Of the six known hydroxycinnamates detected, chlorogenic acid (80.79% in leaves and 87.56% in stems) and caffeic acid (18.98% in leaves and 12.30% in stems) were the most abundant, while arctigenin (77.81% in leaves and 83.40% in stems) and retusin (13.82% in leaves and 10.59% in stems) were the most abundant of the nine known lignans detected. Twelve known benzoic acid derivatives were detected, consisting mainly of ellagic acid (65.44% in leaves and 72.89% in stems), p-hydroxybenzoic acid (25.10% in leaves and 18.95% in stems), and vanillic acid (8.80% in leaves and 7.30% in stems). The rich phytochemical profile of the leaves and stems is an indication of their ability to serve as sources of nutraceuticals. K E Y W O R D Sflavonoids, hydroxycinnamates, lignans, Pandiaka heudelotii, phenolic acids

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“…It has been suggested that low‐level chronic inflammation, resulting in the expression of vascular adhesion molecules on the surface of the endothelium, has long been implicated as a driving factor in the early stages of atherosclerosis (Ley & Huo, ). There is increasing evidence that dietary flavonoids can attenuate the expression of adhesion molecules [vascular cell adhesion molecule‐1 (VCAM‐1) and intercellular adhesion molecule‐1 (ICAM‐1)] in the cellular models of pathogenesis such as oxidative stress, hyperglycemia, and hyperlipidemia (Fratantonio et al, ; Ren et al, ).…”

Section: Structure‐related Effects Of Falvonoids On Endothelial Functionmentioning

confidence: 99%

A review on the structure-activity relationship of dietary flavonoids for protecting vascular endothelial function: Current understanding and future issues

Zhang

Wei

et al. 2018

J Food Biochem

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Nowadays dietary flavonoids attract considerable attention in the prevention of cardiovascular diseases, even though the definitive structure–activity relationships (SARs) of flavonoids are not completely understood. This review exclusively aims to summarize recent evidence for the correlation between structural features of dietary flavonoids and effects on vascular endothelial function (EF). In human studies, the diets rich in one of six flavonoid subclasses namely, flavonol, flavone, flavanol, flavanone, anthocyanin, and isoflavone were reported to have positive effects on EF. However, the clinical evidence supporting SAR establishment was limited and often inconclusive. In in vitro models, the evidence for the activities of metabolized and unmetabolized flavonoids in three protective pathways of EF: nitric oxide bioavailability, induction of antioxidant enzymes, and anti‐inflammation are highlighted. The specific structural characteristics favorable in modulation of each pathway are summarized. Nevertheless, the roles of the substituent property of flavonoid metabolites on endothelial cells function remain to be investigated. Practical applications Due to the potential benefits for cardiovascular health, dietary flavonoids have come into the focus of utilization as a nutraceutical ingredient in food and pharmaceutical industries. Since there are many hundreds of flavonoids in human diets, thus it is very necessary to known if specific structural motifs could confer some flavonoids with higher cardiovascular bioactivity than others. The discussion on SARs for protecting vascular endothelial function will give us important information on utilization of flavonoids in human precise nutrition.

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Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats

Cited by 173 publications

References 52 publications

Antidiabetic potential ofMusaspp. inflorescence: a systematic review

Antidiabetic potential ofMusaspp. inflorescence: a systematic review

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

A review on the structure-activity relationship of dietary flavonoids for protecting vascular endothelial function: Current understanding and future issues

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